The pathogenesis of bacterial keratitis: Studies with Pseudomonas aeruginosa

Clinical and Experimental Optometry

Volumn 85, Issue 5, 2002, Pages 271-278

  Fleiszig, Suzanne M J ^a   Evans, David J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Touro University California   (United States)

Author keywords

Cornea; Epithelium; Keratitis; Pathogenesis; Pseudomonas aeruginosa; Tears

Indexed keywords

GRAM NEGATIVE INFECTION; HUMAN; KERATITIS; MICROBIOLOGY; PSEUDOMONAS AERUGINOSA; REVIEW; RISK FACTOR;

HUMANS; KERATITIS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RISK FACTORS;

EID: 0036716659     PISSN: 08164622     EISSN: 14440938     Source Type: Journal    
DOI: 10.1111/j.1444-0938.2002.tb03082.x     Document Type: Review

References (65)

1. Wang AG, Wu CC, Liu JH. Bacterial corneal ulcer: a multivariate study. Ophthalmologica 1998;212:126-132.
2. Cheng KH, Leung SL, Hoekman HW, Beekhuis WH, Mulder PGH, Geerards AJM, Kijlstra A. Incidence of contact-lens-associated microbial keratitis and its related morbidity. Lancet 1999;354:181-185.
3. Levartovsky S, Rosenwasser GOD, Goodman DF. Bacterial keratitis following laser in situ keratomileusis. Ophthalmology 2001;108:321-325.
4. Schaefer F, Bruttin O, Zografos L, Guex-Crosier, Y. Bacterial keratitis: a prospective clinical and microbiological study. Br J Ophthalmol 2001;85:842-847.
5. Fletcher EL, Fleiszig SMJ, Brennan NA. Lipopolysaccharide in adherence of Pseudomonas aeruginosa to the cornea and contact lenses. Invest Ophthalmol Vis Sci 1993;34:1930-1936.
6. Gupta SK, Berk RS, Masinick S. Hazlett LD. Pili and lipopolysaccharide of Pseudomonas aeruginosa bind to the glycolipid asialo GM1. Infect Immun 1994;62:4572-4579.
7. Gupta SK, Masinick S, Garret M, Hazlett LD. Pseudomonas aeruginosa lipopolysaccharide binds galectin-3 and other human corneal epithelial proteins. Infect Immun 1997;65:2747-2753. (Pubitemid 27264103)
8. Comolli JC, Waite LL, Mostov KE, Engel JN. Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa. Infect Immun 1999;67:3207-3214.
9. Schroeder TH, Zaidi TS, Pier GB. Lack of adherence of clinical isolates of Pseudomonas aeruginosa to asialo-GM1 on epithelial cells. Infect Immun 2001;69:719-729.
10. Simpson DA, Ramphal R, Lory S. Genetic analysis of Pseudomonas aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins. Infect Immun 1992;60:3771-3779.
11. Evans DJ, Matsumoto PS, Widdicombe JH, Maminishkis AA, Miller SS. Pseudomonas aeruginosa induces changes in fluid transport across airway surface epithelia. Am J Physiol [Cell] 1998; 275: C1284-1290.
12. McNamara NA, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C. ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci USA 2001;98:9086-9091.
13. Hobden JA, Gupta SK, Masinick SA, Wu X, Kernacki KA, Berk RS, Hazlett LD. Antireceptor antibodies inhibit Pseudomonas aeruginosa binding to the cornea and prevent corneal perforation. Immunol Cell Biol 1996;74:258-264. (Pubitemid 26186776)
14. Masinick SA, Montgomery CP, Montgomery PC, Hazlett LD. Secretory IgA inhibits Pseudomonas aeruginosa binding to cornea and protects against keratitis. Invest Ophthalmol Vis Sci 1997;38:910-918.
15. Fleiszig SMJ, Zaidi TS, Fletcher EL, Preston MJ, Pier GB. Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection. Infect Immun 1994;62:3485-3492.
16. Fleiszig SMJ, Zaidi TS, Pier GB. Pseudomonas aeruginosa survival and multiplication within corneal epithelial cells in vitro. Infect Immun 1995;63:4072-4077.
17. Fleiszig SMJ, Zaidi TS, Preston MJ, Grout M, Evans DJ, Pier GB. Cytotoxicity and corneal epithelial cell invasion by isolates of Pseudomonas aeruginosa. Infect Immun 1996;64:2288-2294.
18. Fleiszig SMJ, Wiener-Kronish JP, Miyazaki H, Vallas V, Mostov KE, Kanada D, Sawa T, Yen TSB, Frank DW. Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. Infect Immun 1997;65:579-586.
19. Evans DJ, Frank DW, Finck-Barbançon V, Wu C, Fleiszig SMJ. Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity. Infect Immun 1998;66:1453-1459.
20. Pier GB, Grout M, Zaidi TS, Olsen JC, Johnson LG, Yankaskas JR, Goldberg JB. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 1996;271:64-67.
21. Zaidi TS, Lyczak J, Preston M, Pier GB. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Infect Immun 1999;67:1481-1492.
22. Esen M, Grassmé H, Riethmüller J, Riehle A, Fassbender K, Gulbins E. Invasion of human epithelial cells by Pseudomonas aeruginosa involves Src-like tyrosine kinases p60Src and p59Fyn. Infect Immun 2001;69:281-287.
23. Zaidi TS, Fleiszig SMJ, Preston MJ, Goldberg JB, Pier GB. Lipopolysaccharide outer core is a ligand for corneal cell binding and ingestion of Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci 1996;37:976-986.
24. Fleiszig SMJ, Arora SK, Van R, Ramphal R. FlhA, a component of the flagellum assembly apparatus of Pseudomonas aeruginosa, plays a role in internalization by corneal epithelial cells. Infect Immun 2001;69:4931-4937.
25. Finck-Barbançon V, Goranson J, Zhu L, Sawa T, Wiener-Kronish JP, Fleiszig SMJ, Wu C, Mende-Mueller L, Frank DW. ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. Mol Microbiol 1997;25:547-557.
26. Cowell BA, Chen DY, Frank DW, Vallis AJ, Fleiszig SMJ. ExoT of cytotoxic Pseudomonas aeruginosa prevents uptake by corneal epithelial cells. Infect Immun 2000;68:403-406.
27. Krall R, Schmidt G, Aktories K, Barbieri JT. Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein. Infect Immun 2000;68:6066-6068.
28. Lomholt JA, Poulsen K, Kilian M. Epidemic population structure of Pseudomonas aeruginosa: Evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors. Infect Immun 2001;69:6284-6295.
29. Lakkis C, Fleiszig SMJ. Resistance of Pseudomonas aeruginosa isolates to hydrogel contact lens disinfection correlates with cytotoxic activity. J Clin Microbiol 2001;39:1477-1486.
30. Cryz SJ Jr, Pitt TL, Fürer E, Germanier R. Role of lipopolysaccharide in virulence of Pseudomonas aeruginosa. Infect Immun 1984;44:508-513.
31. Knirel YA. Polysaccharide antigens of Pseudomonas aeruginosa. Crit Rev Microbiol 1990;17:273-304.
32. Rocchetta HL, Burrows LL, Lam JS. Genetics of O-Antigen biosynthesis in Pseudomonas aeruginosa. Microbiol Mol Biol Rev 1999;63:523-553.
33. Evans DJ, Kuo TC, Van R, Fleiszig SMJ. The role of lipopolysaccharide in Pseudomonas aeruginosa corneal epithelial cell invasion includes intracellular survival. Invest Ophthalmol Vis Sci 2000; 41: S153.
34. Song PI, Abraham TA, Park Y, Zivony AS, Harten B, Edelhauser HF, Ward SL, Armstrong CA, Ansel JC. The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest Ophthalmol Vis Sci 2001;42:2867-2877.
35. McNamara NA, Van R, Tuchin OS, Fleiszig SMJ. Ocular surface epithelia express mRNA for human beta defensin-2. Exp Eye Res 1999;69:483-490.
36. Goldberg JB, Coyne MJ, Neely AN, Holder IA. Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection. Infect Immun 1995;63:4166-4169.
37. Preston MJ, Fleiszig SMJ, Zaidi TS, Goldberg JB, Shortridge VD, Vasil ML, Pier GB. Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice. Infect Immun 1995;63:3497-3501.
38. O'Callaghan RJ, Engel LS, Hobden JA, Callegan MC, Green LC, Hill JM. Pseudomonas keratitis-The role of an uncharacterized exoprotein, protease IV, in corneal virulence. Invest Ophthalmol Vis Sci 1996;37:534-543.
39. Preston MJ, Seed PC, Toder DS, Iglewski BH, Ohman DE, Gustin JK, Goldberg JB, Pier GB. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect Immun 1997;65:3086-3090.
40. Alionte LG, Cannon BM, White CD, Caballero AR, O'Callaghan RJ, Hobden JA. Pseudomonas aeruginosa LasA protease and corneal infections. Curr Eye Res 2001;22:266-271.
41. Engel LS, Hobden JA, Moreau JM, Callegan MC, Hill JM, O'Callaghan RJ. Pseudomonas deficient in protease IV has significantly reduced corneal virulence. Invest Ophthalmol Vis Sci 1997;38:1535-1542.
42. Ishimoto KS, Lory S. Formation of pili in Pseudomonas aeruginosa requires the alternative σ factor (RpoN) of RNA polymerase. Proc Natl Acad Sci USA 1989;86:1954-1957.
43. Parsek MR, Val DL, Hanzelka BL, Cronan JE, Greenberg EP. Acyl homoserine-lactone quorum-sensing signal generation. Proc Natl Acad Sci USA 1999;96:4360-4365.
44. Rumbaugh KP, Griswold JA, Hamood AN. The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa. Microbes Infect 2000;2:1721-1731.
45. Zhu H, Thuruthyil SJ, Kjelleberg S, Rice S, Givskov M, Willcox MDP. Contribution of Quorum-sensing systems to the virulence of Pseudomonas aeruginosa during corneal infections. Invest Ophthalmol Vis Sci 2001; 42: S514.
46. Fleiszig SMJ, Lee EJ, Wu C, Andika RC, Vallas V, Portoles M, Frank DW. Cytotoxic strains of Pseudomonas aeruginosa can damage the intact corneal surface in vitro. CLAO J 1998;24:41-47.
47. Lakkis C, Mendoza MN, Fan D, Chauhan A, Srinivas S P, Fleiszig SMJ. Shear stress reduces corneal epithelial cell killing by cytotoxic P. aeruginosa. Invest Ophthalmol Vis Sci 2001; 42: S593.
48. McClellan KA. Mucosal defense of the outer eye. Surv Ophthalmol 1997;42:233-246.
49. Fleiszig SMJ, Zaidi TS, Ramphal R, Pier GB. Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus. Infect Immun 1994;62:1799-1804.
50. McNamara NA, Fleiszig SMJ. Human tear film components bind Pseudomonas aeruginosa. Adv Exp Med Biol 1998;438:653-659.
51. Fleiszig SMJ, McNamara NA, Evans DJ. The tear film and defense against infection. Adv Exp Med Biol 2001; 506: in press.
52. Fleiszig SMJ, Evans DJ, Do N, Vallas V, Shin S, Mostov KE. Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity. Infect Immun 1997;65:2861-2867.
53. Fleiszig SMJ, Vallas V, Jun. CH, Mok L, Balkovetz DF, Roth, MG, Mostov KE. Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor. Infect Immun 1998;66:3443-3446.
54. Cole N, Krockenberger M, Bao S, Beagley KW, Husband AJ, Willcox MDP. Effects of exogenous interleukin 6 during Pseudomonas aeruginosa corneal infection. Infect Immun 2001;69:4116-4119.
55. Ladage PM, Yamamoto K, Ren DH, Li L, Jester JV, Petroll WM, Cavanagh HD. Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells. Ophthalmology 2001;108:1279-1288.
56. Ladage PM, Yamamoto K, Ren DH, Li L, Jester JV, Petroll WM, Bergmanson JPG, Cavanagh HD. Proliferation rate of rabbit corneal epithelium during overnight rigid contact lens wear. Invest Ophthalmol Vis Sci 2001;42:2804-2812.
57. Thakur A, Willcox MDP. Contact lens wear alters the production of certain inflammatory mediators in tears. Exp Eye Res 2000;70:255-259.
58. McNamara NA, Polse KA, Fukunaga SA, Maebori JS, Suzuki RM. Soft lens extended wear affects epithelial barrier function. Ophthalmology 1998;105:2330-2335.
59. Kernacki KA, Barrett RP, Hazlett LD. Evidence for TIMP-1 protection against P. aeruginosa-induced corneal ulceration and perforation. Invest Ophthalmol Vis Sci 1999;40:3168-3176.
60. Cole N, Bao S, Willcox MDP, Husband AJ. Expression of interleukin-6 in the cornea in response to infection with different strains of Pseudomonas aeruginosa. Infect Immun 1999;67:2497-2502.
61. Kernacki KA, Barrett RP, McClellan SA, Hazlett LD. Aging and PMN response to P. aeruginosa infection. Invest Ophthalmol Vis Sci 2000;41:3019-3025.
62. Kernacki KA, Barrett R P, McClellan S, Hazlett LD. MIP-1 alpha regulates CD4+ T cell chemotaxis and indirectly enhances PMN persistence in Pseudomonas aeruginosa corneal infection. J Leuk Biol 2001;70:911-919.
63. Hobden JA, Masinick SA, Barrett RP, Hazlett LD. Aged mice fail to upregulate ICAM-1 after Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 1995;36:1107-1114.
64. Hobden JA, Masinick SA, Barrett RP, Hazlett LD. Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice. Infect Immun 1997;65:2754-2758.
65. Twining SS, Kirschner SE, Mahnke LA, Frank DW. Effect of Pseudomonas aeruginosa elastase, alkaline protease, and exotoxin A on corneal proteinases and proteins. Invest Ophthalmol Vis Sci 1993;34:2699-2712.