Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S

Infection and Immunity

Volumn 65, Issue 2, 1997, Pages 579-586

  Fleiszig, Suzanne M J ^a   Wiener Kronish, Jeanine P ^b   Miyazaki, Hiroshi ^b   Vallas, V ^a   Mostov, Keith E ^b   Kanada, Daniel ^b   Sawa, Teiji ^b   Yen, T S Benedict ^c   Frank, Dara W ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; CELL INVASION; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE LOCUS; LUNG ALVEOLUS EPITHELIUM; LUNG INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; REGULON; STRUCTURAL GENE; TRANSCRIPTION REGULATION;

EID: 0031020233     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.2.579-586.1997     Document Type: Article

References (29)

1. Apodaca, G., M. Bomsel, R. Lindstedt, J. Engel, D. Frank, K. E. Mostov, and J. Wiener-Kronish. 1995. Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing. Infect. Immun. 63:1541-1551.
2. Bodey, G. P., R. Bolivar, V. Fainstein, and L. Jadeja. 1983. Infections caused by Pseudomonas aeruginosa. Rcv. Infect. Dis. 5:279-313.
3. Fleiszig, S. M. J., T. S. Zaidi, E. L. Fletcher, M. J. Preston, and G. B. Pier. 1994. Pseudomonas aeruginosa invades corncal epithelial cells during experimental infection. Infect. Immun. 62:3485-3492.
4. Fleiszig, S. M. J., T. S. Zaidi, and G. B. Pier. 1995. Pseudomonas aeruginosa survival and multiplication within corncal epithelial cells in vitro. Infect. Immun. 63:4072-4077.
5. Fleiszig, S. M. J., T. S. Zaidi, M. J. Preston, M. Grout, D. J. Evans, and G. B. Pier. The relationship between cytotoxicity and corneal epithelial cell invasion by clinical isolates of Pseudomonas aeruginosa. Infect. Immun. 64:2288-2294.
6. Fletcher, E. L., S. M. J. Fleiszig, and N. A. Brennan. 1993. Lipopolysaccharide in adherence of Pseudomonas aeruginosa to the cornea and contact lenses. Invest. Ophthalmol. Visual Sci. 34:1930-1936.
7. Frank, D. W., and B. H. Iglewski. 1991. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. J. Bacteriol. 173:6460-6468.
8. Frank, D. W., G. Nair, and H. P. Schweizer. 1994. Construction and characterization of chromosomal insertional mutations of the Pseudomonas aeruginosa exoenzyme S trans-regulatory locus. Infect. Immun. 62:554-563.
9. Gerke, J. R., and M. V. Maglioco. 1971. Experimental Pseudomonas aeruginosa infection of the mouse cornea. Infect. Immun. 3:209-216.
10. Hovey, A. K., and D. W. Frank. 1995. Analyses of the DNA binding and transcriptional activation properties of ExsA, the transcriptional activator of the exoenzyme S regulon. J. Bacteriol. 177:4427-4436.
11. Iglewski, B. H., J. Sadoff, M. J. Bjorn, and E. S. Maxwell. 1978. Pseudomonas exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. Proc. Natl. Acad. Sci. USA 75:3211-3215.
12. Kudoh, I., J. P. Wiener-Kronish, S. Hashimoto, J.-F. Pittet, and D. Frank. 1994. Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury. Am. J. Physiol. (Lung Cell. Mol. Physiol. 12) 267:L551-L556.
13. Kulich, S. M., T. L. Yahr, L. M. Mende-Mueller, J. T. Barbieri, and D. W. Frank. 1994. Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388. J. Biol. Chem. 269:10431-10437.
14. Liu, S., T. L. Yahr, D. W. Frank, and J. T. Barbieri. Biochemical relationships between the catalytic domains of the 53-and 49-kDa forms of exoenzyme S of Pseudomonas aeruginosa. Submitted for publication.
15. McElroy, M. C., J.-F. Pittet, S. Hashimoto, L. Allen, J. P. Wiener-Kronish, and L. G. Dobbs. 1995. A type I cell-specific protein is a biochemical marker of epithelial injury in a rat model of pneumonia. Am. J. Physiol. (Lung Cell. Mol. Physiol. 12) 268:L181-L186.
16. Nicas, T. I., and B. H. Iglewski. 1984. Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. Infect. Immun. 45:470-474.
17. Nicas, T. I., and B. H. Iglewski. 1985. The contribution of exoproducts to virulence of Pseudomonas aeruginosa. Can. J. Microbiol. 31:387-392.
18. Nicas, T. I., J. Bradley, J. E. Lochner, and B. H. Iglewski. 1985. The role of exoenzyme S in infections with Pseudomonas aeruginosa. J. Infect. Dis. 152: 716-721.
19. Persson, C., R. Nordfelth, A. Holmstrom, S. Hakansson, R. Rosqvist, and H. Wolf-Watz. 1995. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell. Mol. Microbiol. 18:135-150.
20. Pier, G. B., M. Grout, T. S. Zaidi, J. C. Olsen, L. G. Johnson, J. R. Yankaskas, and J. B. Goldberg. 1996. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 271:64-67.
21. Ramphal, R., P. A. Small, J. W. Shands, and W. Fischisweiger. 1980. Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation. Infect. Immun. 27:614-619.
22. Ramphal, R., M. T. McNiece, and F. M. Polack. 1981. Adherence of Pseudomonas aeruginosa to the injured cornea: a step in the pathogenesis of corneal infections. Ann. Ophthalmol. 13:421-425.
23. Ramphal, R., and M. Pyle. 1983. Adherence of mucoid and nonmucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium. Infect. Immun. 41:345-351.
24. Rosqvist, R., K.-E. Magnusson, and H. Wolf-Watz. 1994. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J. 13:964-972.
25. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
26. Sory, M.-P., and G. R. Cornelis. 1994. Translocation of a hybrid YopE-adenylate cyclase from Yersinia enteracolitica into HeLa cells. Mol. Microbiol. 14:583-594.
27. Yahr, T. L., A. K. Hovey, S. M. Kulich, and D. W. Frank. 1995. Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene. J. Bacteriol. 177:1169-1178.
28. Yahr, T. L., J. T. Barbieri, and D. W. Frank. 1996. Genetic relationship between the 53-and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa. J. Bacteriol. 178:1412-1419.
29. Yahr, T. L., J. Goranson, and D. W. Frank. Exoenzyme S of Pseudomonas aeruginosa is secreted by a Type III secretion pathway. Mol. Microbiol., in press.