Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer

Clinical Cancer Research

Volumn 8, Issue 9, 2002, Pages 2970-2975

  Lee, Ho Young ^a   Suh, Young Ah ^a   Lee, Janet I ^a   Hassan, Khaled A ^a   Mao, Li ^a   Force, Thomas ^b   Gilbert, Brian E ^c   Jacks, Tyler ^d   Kurie, Jonathan M ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CALCIUM PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AEROSOL; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DELIVERY SYSTEM; GENE TARGETING; GENE TRANSFER; INHIBITION KINETICS; JET INJECTION; LUNG CANCER; MOUSE; NEBULIZATION; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ADENOVIRIDAE; AEROSOLS; ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; EXONS; GENE THERAPY; GENES, DOMINANT; GENES, RAS; GENES, REPORTER; GENETIC VECTORS; HUMANS; LAC OPERON; LUNG NEOPLASMS; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; POINT MUTATION; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036715294     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Cancer statistics 2000
2. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
3. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
4. Both farnesyl-transferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation, but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
5. Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells
6. Development of cationic liposome formulations for intratracheal gene therapy of early lung cancer
7. Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes
8. High efficiency gene transfer and high level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus
9. Therapeutic effect of a retroviral wild type p53 expression vector in an orthotopic lung cancer model
10. Gene therapy for lung disease: Hype or hope?
11. Adenoviral gene transfer is inhibited by soluble factors in malignant pleural effusions
12. Enhanced gene expression in mouse lung after PEI-DNA aerosol delivery
13. Basis of pulmonary toxicity associated with cationic lipid-mediated gene tranfer to the mammalian lung
14. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid:cationic lipid complexes
15. Receptors mediating adenovirus attachment and internalization
16. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector
17. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
18. Gene transfer by guanidinium-cholesterol: Dioleoylphosphatidyl-ethanolamine liposome-DNA complexes in aerosol
19. Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo
20. Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection
21. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
22. A human bronchial epithelial cell strain with unusual in vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection
23. All-trans retinoic acid inhibits jun N-terminal kinase-dependent signaling pathways
24. Role of stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy
25. An essential role for rac in ras transformation
26. Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17
27. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor gene
28. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
29. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4A
30. The jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
31. 2-terminal kinase in oncogenic Ras-induced morphologic transformation of human lung carcinoma cells