Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector

Human Gene Therapy

Volumn 7, Issue 3, 1996, Pages 319-331

  Dong, Jian Yun ^a   Wang, Danher ^a   Van Ginkel, Frederik W ^c   Pascual, David W ^c   Frizzell, Raymond A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; VIRUS VECTOR;

ADENOVIRUS; ANATOMY; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYSTIC FIBROSIS; DEFENSE MECHANISM; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENOME; HISTOPATHOLOGY; HOST CELL; IMMUNE RESPONSE; LUNG; MALE; MOUSE; NONHUMAN; RECIPIENT; TRANSGENE;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES;

EID: 0030023343     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.3-319     Document Type: Article

References (41)

1. ACSADI, G., JANI, A., MASSIE, B., SIMONEAU, M., HOLLAND, P., BLASCHUK, K., and KARPATI, G. (1994). A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity. Hum. Mol. Genet. 3, 579-584.
2. BALLAY, A., LEVRERO, M., BUENDIA, M.A., TIOLLAIS, P., and PERRICAUDET, M. (1985). In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses. EMBO J. 4, 3861-3865.
3. BERKNER, L. (1988). Development of adenovirus vectors for the expression of heterologous genes. Biotechniques 6, 616-629.
4. BETT, J., PREVEC, L., and GRAHAM, F.L. (1993). Packaging capacity and stability of human adenovirus type 5 vectors. J. Virol. 67, 5911-5921.
5. BETT, J., HADDARA, W., PREVEC, L., and GRAHAM, F.L. (1994). An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91, 8802-8806.
6. BOAT, T.F., WELSH, M.J., and BEAUDET, A.L. (1989). Cystic Fibrosis. In: The Metabolic Basis of Inhererited Disease. (McGraw-Hill, New York) pp. 2649-2680.
7. BOUT, A., PERRICAUDET, M., BASKIN, G., IMLER, J.L., SCHOLTE, B.J., PAVIRANI, A., and VALERIO, D. (1994). Lung gene therapy: in vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium. Hum. Gene Ther. 5, 3-10.
8. CHENG, H., GREGORY, R.J., MARSHALL, J., PAUL, S., SOUZA, D.W., WHITE, G.A., O'RIORDAN, C.R., and SMITH, A.E. (1990). Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell 63, 827-834.
9. DEFILIPPI, P., VAN HINSBERGH, V., BERTOLOTTO, A., ROSSINO, P., SILENGO, L., and TARONE, G. (1991). Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells. J. Cell Biol. 114, 855-863.
10. DENNING, M., OSTEDGAARD, L.S., and WELSH, M.J. (1992). Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia. J. Cell. Biol. 118, 551-559.
11. ENGELHARDT, F., SIMON, R.H., YANG, Y., ZEPEDA, M., WEBER, P.S., DORANZ, B., GROSSMAN, M., and WILSON, J.M. (1993). Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum. Gene Ther. 4, 759-769.
12. FRIZZELL, A., RECHKEMMER, G., and SHOEMAKER, R.L. (1986). Altered regulation of airway epithelial cell chloride channels in cystic fibrosis. Science 233, 558-560.
13. GINSBERG, H.S., MOLDAWER, L.L., SEHGAL, P.B., REDINGTON, M., KILIAN, P.L., CHANOCK, R.M., and PRINCE, G.A. (1991). A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc. Natl. Acad. Sci. USA 88, 1651-1655.
14. GOLDMAN, M.J., and WILSON, J.M. (1995). Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69, 5951-5958.
15. GRAHAM, L., and PREVEC, L. (1992). Adenovirus-based expression vectors and recombinant vaccines. Biotechnology 20, 363-390.
16. GRAHAM, L., and VAN DER EB, A.J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
17. GRAHAM, L., SMILEY, J., RUSSELL, W.C., and NAIRN, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-74.
18. GRUBB, R., PICKLES, R.J., YE, H., YANKASKAS, J.R., VICK, R.N., ENGELHARDT, J.F., WILSON, J.M., JOHNSON, L.G., and BOUCHER, R.C. (1994). Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 371, 802-806.
19. - channels in CF: Lack of activation by protein kinase C and cAMP-dependent protein kinase. Science 244, 1351-1353.
20. JAFFE, A., DANEL, C., LONGENECKER, G., METZGER, M., SETOGUCHI, Y., ROSENFELD, M.A., GANT, T.W., THORGEIRSSON, S.S., STRATFORD, P.L., PERRICAUDET, M., PAVIRANI, A., LECOCQ, J.-P., and CRYSTAL, R.G. (1992). Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nature Genet. 1, 372-378.
21. KORHONEN, M., YLANNE, J., LAITINEN, L., COOPER, H.M., QUARANTA, V., and VIRTANEN, I. (1991). Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta. Lab. Invest. 65, 347-356.
22. PASCUAL, D.W., McGHEE, J.R., KIYONO, H., and BOST, K.L. (1991). Neuroimmune modulation of lymphocyte function-I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures. Inter. Immunol. 3, 1223-1229.
23. PREVEC, L., SCHNEIDER, M., ROSENTHAL, K.L., BELBECK, L.W., DERBYSHIRE, J.B., and GRAHAM, F.L. (1989). Use of human adenovirus-based vectors for antigen expression in animals. [Published erratum appears in J. Gen. Virol. 70(Pt. 9), 2539, 1989.] J. Gen. Virol. 70, 429-434.
24. RICH, P., COUTURE, L.A., CARDOZA, L.M., GUIGGIO, V.M., ARMENTANO, D., ESPINO, P.C., HEHIR, K., WELSH, M.J., SMITH, A.E., and GREGORY, RJ. (1993). Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Hum. Gene Ther. 4, 461-476.
25. RIORDAN, J.R., ROMMENS, J.M., KEREM, B., ALON, N., ROZMAHEL, R., GRZELCZAK, Z., ZIELENSKI, J., LOK, S., PLAVSIC, N., CHOU, J.L., DRUMM, M.L., IANNUZZI, M.C., COLLINS, F.S., and TSUI, L.-C. (1989). Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. [Published erratum appears in Science 245, 1437, 1989]. Science 245, 1066-1073.
26. ROSENFELD, M.A., SIEGFRIED, W., YOSHIMURA, K., YONEYAMA, K., FUKAYAMA, M., STIER, L.E., PAAKKO, P.K., GILARDI, P., STRATFORD, P.L., PERRICAUDET, M., JALLAT, S., PAVTRANI, A., LECOCQ, J.-P., and CRYSTAL, R.G. (1991). Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science 252, 431-434.
27. ROSENFELD, M.A., YOSHIMURA, K., TRAPNELL, B.C., YONEYAMA, K., ROSENTHAL, E.R., DALEMANS, W., FUKAYAMA, M., BARGON, J., STIER, L.E., STRATFORD-PERRICAUDET, L., PERRICAUDET, M., GUGGINO, W.B., PAVIRANI, A., LECOCQ, J.-P., and CRYSTAL, R.G. (1992). In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68, 143-155.
28. SCHNEIDER, M., GRAHAM, F.L., and PREVEC, L. (1989). Expression of the glycoprotein of vesicular stomatitis virus by infectious adenovirus vectors. J. Gen. Virol. 70, 417-427.
29. SIMON, H., ENGELHARDT, J.F., YANG, Y., ZEPEDA, M., WEBER, P.S., GROSSMAN, M., and WILSON, J.M. (1993). Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Hum. Gene Ther. 4, 771-780.
30. STRAUS, S.E. (1984). Adenovirus infections in humans. In: The Adenoviruses. (Platium Press, New York) pp. 451-496.
31. TERPE, J., STARK, H., RUIZ, P., and IMHOF, B.A. (1994). Alpha 6 integrin distribution in human embryonic and adult tissues. Histochemistry 101, 41-49.
32. WELSH, J., and SMITH, A.E. (1993). Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 73, 1251-1254.
33. WELSH, J., SMITH, A.E., ZABNER, J., RICH, D.P., GRAHAM, S.M., GREGORY, R.J., PRATT, B.M., and MOSCICKI, R.A. (1994). Cystic fibrosis gene therapy using an adenovirus vector: in vivo safety and efficacy in nasal epithelium. Hum. Gene Ther. 5, 209-219.
34. WILSON, M., ENGELHARDT, J.F., GROSSMAN, M., SIMON, R.H., and YANG, Y. (1994). Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: A phase I trial. Hum. Gene Ther. 5, 501-519.
35. YANG, Y., NUNES, F.A., BERENCSI, K., FURTH, E.E., GONCZOL, E., and WILSON, J.M. (1994). Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91, 4407-4411.
36. YEI, S., MITTEREDER, N., TANG, K., O'SULLIVAN, C., and TRAPNELL, B.C. (1994). Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1, 192-200.
37. YEI, S., MITTEREDER, K., WERT, S.N., WHITSETT, J.A., WILMOTT, R.W., and TRAPNELL, B.C. (1994). In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum. Gene Ther. 5, 731-744.
38. ZABNER, J., COUTURE, L.A., GREGORY, R.J., GRAHAM, S.M., SMITH, A.E., and WELSH, MJ. (1993a). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75, 207-216.
39. ZABNER, J., COUTURE, L.A., GREGORY, R.J., GRAHAM, S.M., SMITH, A.E., and WELSH, MJ. (1993b). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75, 207-216.
40. ZABNER, L.A., COUTURE, R.J., SMITH, A.E., and WELSH, M.J. (1994a). Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro. Hum. Gene Ther. 5, 585-593.
41. ZABNER, J., PETERSEN, D.M., PUGA, A.P., GRAHAM, S.M., COUTURE, L.A., KEYES, L.D., LUKASON, M.J., ST, G.J., GREGORY, R.J., SMITH, A.E., and WELSH, M.J. (1994b). Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nature Genet. 6, 75-83.