Astrocytes are less efficient in the removal of apoptotic lymphocytes than microglia cells: Implications for the role of glial cells in the inflamed central nervous system

Journal of Neuropathology and Experimental Neurology

Volumn 61, Issue 9, 2002, Pages 760-766

  Magnus, Tim ^a   Chan, Andrew ^a   Linker, Ralf A ^a   Toyka, Klaus V ^a   Gold, Ralf ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Apoptosis; Astrocytes; Autoimmunity; Experimental autoimmune encephalomyelitis (EAE); Inflammation; Microglia; Multiple sclerosis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHYLPREDNISOLONE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOIMMUNE DISEASE; CELL INTERACTION; CELL SPECIFICITY; CELL TYPE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GLIA CELL; IMMUNOMODULATION; IMMUNOREGULATION; INFLAMMATION; LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROENVIRONMENT; MICROGLIA; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; THYMOCYTE;

EID: 0036715053     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.9.760     Document Type: Article

References (31)

1. T-cell apoptosis in inflammatory brain lesions: Destruction of T cells does not depend on antigen recognition
2. T-cell apoptosis in autoimmune diseases: Termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms
3. Apoptosis in the nervous system in experimental allergic encephalomyelitis
4. T-cell apoptosis in situ in experimental autoimmune encephalomyelitis following methylprednisolone pulse therapy
5. Apoptosis: The importance of being eaten
6. Apoptosis in resolution of inflammation
7. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
8. Immunosuppressive effects of apoptotic cells
9. Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: Mechanism for removal of apoptotic cells in the inflamed nervous system
10. Characterization of ameboid microglia isolated from developing mammalian brain
11. Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death. A model for T-cell apoptosis in vivo
12. Production of nitrite by neonatal rat microglial cells/brain macrophages
13. Plasma membrane phospholipid asymmetry precedes DNA fragmentation in different apoptotic cell models
14. Usage of Vbeta3.3 T-cell receptor by myelin basic protein-specific encephalitogenic T-cell lines in the Lewis rat
15. Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms
16. Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response
17. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
18. Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: Mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion
19. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
20. Apoptotic elimination of V beta 8.2+ cells from the central nervous system during recovery from experimental autoimmune encephalomyelitis induced by the passive transfer of V beta 8.2+ encephalitogenic T cells
21. Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation
22. Phagocytosis in the rat optic nerve following Wallerian degeneration
23. Phagocytosis of apoptotic lymphocytes by oligodendrocytes in experimental autoimmune encephalomyelitis
24. Production of proinflammatory cytokines by phorbol myristate acetate- treated THP-1 cells and monocyte-derived macrophages after phagocytosis of apoptotic CTLL-2 cells
25. Multiple sclerosis: A role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study
26. Interaction of astrocytes and newly formed oligodendrocytes in resolving multiple sclerosis lesions
27. Astrocytes attenuate oligodendrocyte death in vitro through an alpha(6) integrin-laminin-dependent mechanism
28. Involvement of non-neuronal cells in entorhinal-hippocampal reorganization following lesions
29. The pathobiology of the oligodendrocyte
30. Colocalization of multiple antigens and specific DNA. A novel method using methyl methacrylate-embedded semithin serial sections and catalyzed reporter deposition
31. Microglia: A sensor for pathological events in the CNS