Going mad with Smads

New England Journal of Medicine

Volumn 341, Issue 15, 1999, Pages 1144-1146

  Zhou, S ^a   Kinzler, K W ^a   Vogelstein, B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER; CANCER GENETICS; CANCER RESEARCH; CANCER RISK; COLON CARCINOGENESIS; COLORECTAL CANCER; GENE MUTATION; HUMAN; PRIORITY JOURNAL;

ADENOMA; ANIMALS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTESTINAL POLYPS; MICE; MUTATION; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033533823     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199910073411510     Document Type: Article

References (8)

1. Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 1998;92:645-56.
2. Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S. Frequency of Smad gene mutations in human cancers. Cancer Res 1997;57:2578-80.
3. Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998;94:703-14.
4. Yang X, Letterio JJ, Lechleider RJ, et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J 1999;18:1280-91.
5. Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999;19:2495-504.
6. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998; 67:753-91.
7. Grady WM, Myeroff LL, Swinler SE, et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res 1999;59:320-4.
8. Weinstein IB. Cyclins, disordered cell circuitry and cancer prevention. Nakahara Memorial Lecture. In: Fundamentals of cancer prevention: 27th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1996:76-9.