Oestrogen induce G1 arrest in benzo[a]pyrene-treated MCF-7 breast cells whilst enhancing genotoxicity and clonogenic survival

Mutagenesis

Volumn 17, Issue 5, 2002, Pages 431-438

  Davis, Cordula ^a   Bhana, Sara ^a   Shorrocks, A Julie ^a   Martin, Francis L ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; ESTRADIOL; ESTRIOL; ESTROGEN DERIVATIVE; ESTRONE; DNA; ESTROGEN;

ARTICLE; BREAST CARCINOGENESIS; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CHROMOSOME DAMAGE; CLONOGENESIS; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; MICRONUCLEUS TEST; MITOSIS INHIBITION; PRIORITY JOURNAL; BREAST TUMOR; CELL CULTURE; CELL DIVISION; CLONOGENIC ASSAY; DRUG COMBINATION; DRUG EFFECT; FEMALE; GENETICS; MICRONUCLEUS; MUTAGEN TESTING; PATHOLOGY;

MINK CELL FOCUS-FORMING VIRUS;

BENZO(A)PYRENE; BREAST NEOPLASMS; CELL DIVISION; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; DNA DAMAGE; DNA, NEOPLASM; DRUG COMBINATIONS; ESTROGENS; FEMALE; G0 PHASE; G1 PHASE; HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENICITY TESTS; S PHASE; TUMOR CELLS, CULTURED;

EID: 0036708601     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. The ovarian cycle
2. Paracelsus to parascience: The environmental cancer distraction
3. Mammalian G1- and S-phase checkpoints in response to DNA damage
4. WAF1 proteins and cell cycle distribution
5. Estrogens as endogenous genotoxic agents-DNA adducts and mutations
6. DNA adducts from carcinogenic and noncarcinogenic enantiomers of benzo[a]pyrene dihydrodiol epoxide
7. Environmental carcinogens that may be involved in human breast cancer etiology
8. Estrogens and breast cancer
9. Increased formation of micronuclei after hormonal stimulation of cell proliferation in human breast cancer cells
10. The initiation of breast and prostate cancer
11. Cambridge Monographs on Cancer Research, Human Cancer: Epidemiology and Environmental Causes
12. Estrogens and breast cancer
13. WAF1 in the human carcinoma cell line MCF-7
14. Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines
15. 1 arrest in MCF-7 cells
16. Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen
17. Paradoxical regulation of Bcl-2 family proteins by 17β-oestradiol in human breast cancer cells MCF-7
18. Hormones and hormonomimetic compounds in the etiology of cancer
19. waf1 in the human MCF-7
20. Genotoxins and the initiation of sporadic breast cancer
21. DNA damage in breast epithelial cells: Detection by the single-cell gel (comet) assay and induction by human mammary lipid extracts
22. The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis ('comet') assay in metabolically-competent MCL-5 cells
23. Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells
24. Genotoxicity of human breast milk from different countries
25. Short tandem repeat profiling provides an international reference standard for human cell lines
26. Cancer epidemiology in the last century and the next decade
27. Heterocyclic aromatic amines induce DNA strand breaks and cell transformation
28. Polycyclic aromatic hydrocarbons in the diet
29. Estrogen, DNA damage and mutations
30. Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: A bio-historical perspective with updates
31. Cell cycle control, checkpoint mechanisms and genotoxic stress
32. Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
33. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1980
34. Genotoxic effects of oestrogens in breast cells detected by the micronucleus assay and the Comet assay
35. Migration patterns and breast cancer risk in Asian-American women