Paradoxical regulation of Bcl-2 family proteins by 17β-oestradiol in human breast cancer cells MCF-7

British Journal of Cancer

Volumn 81, Issue 3, 1999, Pages 387-392

  Leung, L K ^a   Wang, T T Y ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

17 oestradiol; Apoptosis; Bcl 2; Bcl x(L); Breast cancer

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL X; RIBONUCLEASE; STEROID HORMONE; TAMOXIFEN;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOCARCINOMA; APOPTOSIS; BCL-X PROTEIN; BREAST NEOPLASMS; CELL COUNT; DIHYDROTESTOSTERONE; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NEOPLASM PROTEINS; NEOPLASMS, HORMONE-DEPENDENT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; TAMOXIFEN;

EID: 0032837384     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690706     Document Type: Article

References (35)

1. Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305-1308
2. Bardelli A, Longati P, Albero D, Goruppi S, Schneider C, Ponzetto C and Comoglio PM (1996) HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J 15: 6205-6212
3. Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sirkorska M, Walker R and Hermann RS (1996) Active cell death induced by the anti-estrogens tamoxifen and ICI 164384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 17: 1595-1607
4. Bargou RC, Daniel PT, Mapara MY, Bommert K, Wagener C, Kallinich B, Royer HD and Dorken B (1995) Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer 16: 854-859
5. Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G and Lutz RJ (1995) A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J 14: 5589-5596
6. de Cupis A and Favoni RE (1997) Oestrogen/growth factor cross-talk in breast carcinoma: a specific larger for novel antioestrogens. Trends Pharmacol Sci 18: 245-251
7. Farrow, SN, White JHM, Martinou I, Raven T, Pun K-T, Grinham CJ, Martinour J-C and Brown R (1995) Cloning of a bcl-2 homologue by interaction with adenovirus EIB 19K. Nature 374: 731-73
8. Fishman J, Osborne MP and Telang NT (1995) The role of estrogen in mammary carcinogenesis. Ann NY Acad Sci 768: 91-100
9. Grillot DA, Gonzalez-Garcia M, Ekhterae D, Duan L, Inohara N, Ohta S, Seldin MF and Nunez G (1997) Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol 158: 4750-4757
10. Herrmann JL, Beham AW, Sarkiss M, Chiao PJ, Rands MT, Bruckheimer EM, Brisbay S and McDonnell TJ (1997) Bcl-2 suppresses apoptosis resulting from dispruption of the NF-kappa B survival pathway. Exp Cell Res 237: 101-109
11. Huang Y, Ray S, Reed JC, Ibrado AM, Tang C, Nawabi A and Bhalla K (1997) Estrogen increases intracellulur p26 Bcl-2 to p21 Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells. Breast Cancer Res Treat 42: 73-81
12. Hu Y, Benedict MA, Wu D, Inohara N and Nunez G (1998) Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA 95: 4386-4391
13. Jordan VC (1998) Antiestrogenic action of raloxifene and tamoxifen: today and tomorrow. J Natl Cancer Inst 90: 967-971
14. Kandouz M, Siromachkova M, Jacob D, Chretien-Marquet B, Therwath A and Gompel A (1996) Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells. Int J Cancer 68: 120-125
15. Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD (1997) The release of cytochrome c from mitochondria blocked. Science 275: 1129-1132
16. Kroemer G (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3: 614-620
17. Kyprianou N, English HF, Davidson NE and Isaacs JT (1991) Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res 51: 162-166
18. Leung LK, Do L and Wang TTY (1998) Regulation of death promoter Bak expression by cell density and 17β-estradiol in MCF-7 cell. Cancer Lett 124: 47-52
19. McDonnell TJ, Beham A, Sarkiss M, Andersen M and Lo P (1996) Importance of the Bcl-2 family in cell death regulation. Experientia 52: 1008-1017
20. Mikulski SM (1994) Pathogenesis of cancer in view of mutually opposing apoptotic and anti-apoptotic growth signals (Review) Int J Oncol 4: 1257-1263
21. Nenci I, Marchetti E and Qucerzoli P (1988) Commentary on human mammary preneoplasia. The estrogen receptor-promotion hypothesis. J Steroid Biochem 30: 105-106
22. Olopade OI, Adeyanju MO, Safa AR, Hagos F, Mick R, Thompson CB and Recant WM (1997) Over-expression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J Sci Am 3: 230-237
23. Pecci A, Scholz A, Pelster D and Beato M (1997) Progestins prevent apoptosis in a rat endometrial cell line and increase the ratio of bcl-XL to bcl-XS. J Biol Chem 272: 11791-11798
24. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6
25. Saeed B, Zhang H and Ng SC (1997) Apoptotic program is initiated but not completed in LNCap cells in response to growth in charcoal-stripped media. Prostate 31: 145-152
26. Sattle M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB and Fesik SW (1997) Structure of Bcl-x(L)-Bak peptide complex: recognition between regulators of apoptosis. Science 275: 983-986
27. Srinivasan A, Li F, Wong A, Kodandapani L, Smidt R Jr, Krebs JF, Fritz LC, Wu JC and Tomaselli KJ (1998) Bcl xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J Biol Chem 273: 4523-4529
28. Teixeira C, Reed JC and Pratt MA (1995) Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 55: 3902-3907
29. Tsujimoto Y, Cossman J, Jaffe E and Croce CM (1985) Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443
30. Wallach D, Boldin M, Varfolomeev E, Beyaert R, Vandenabeele P and Fiers W (1997) Cell death induction by receptors of the TNF filmily: towards a molecular understanding. FEBS Lett 410; 96-106
31. Wang TT and Phang JM (1995) Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res 55: 2487-2489
32. Wyllie AH (1997) Apoptosis and carcinogenesis. Eur J Cell Biol 73: 189-197
33. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP and Wang X (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275; 1129-1132
34. Zha JP, Harada H, Yang E, Jockel J and Korsmeyer SJ (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-x(L). Cell 87: 619-628
35. Zhang GJ, Kimijima I, Abe R, Watanabe T, Kanno M, Hara K and Tsuchiya A (1998) Apoptotic index correlates to bcl-2 and p53 protein expression, histological grade and prognosis in invasive breast cancers. Anticancer Res 18: 1989-1998