Population analysis of CD4+ T cell chemokine receptor transcript expression during in vivo type-1 (mycobacterial) and type-2 (schistosomal) immune responses

Journal of Leukocyte Biology

Volumn 72, Issue 2, 2002, Pages 363-372

  Chiu, Bo Chin ^a   Shang, Xiao Zhou ^a   Stolberg, Valerie R ^b   Komuniecki, Eric ^b   Chensue, Stephen W ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c VAAAHS   (United States)

Author keywords

Granulomas; Th1; Th2

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR8; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 4; MYCOBACTERIUM ANTIGEN; PARASITE ANTIGEN;

ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; FEMALE; GENE EXPRESSION; HELPER CELL; IMMUNOSTIMULATION; INFLAMMATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, PROTOZOAN; FEMALE; GENE EXPRESSION REGULATION; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-4; MICE; MICE, INBRED CBA; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; RNA, MESSENGER; SCHISTOSOMA MANSONI; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS; TUBERCULIN;

ANIMALIA; MYCOBACTERIUM;

EID: 0036697290     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., Sinigaglia, F. (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187, 129-134.
2. Sallusto, F., Lenig, D., Mackay, C. R., Lanzavecchia, A. (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875-883.
3. Annunziato, F., Galli, G., Romagnani, P., Cosmi, L., Manetti, R., Maggi, E., Romagnani, S. (1999) Chemokine receptors and other surface molecules preferentially associated with human Th1 or Th2 cells. Microbes Infect. 1, 103-106.
4. Sallusto, F., Lanzavecchia, A., Mackay, C. R. (1998) Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol. Today 19, 568-574.
5. Annunziato, F., Cosmi, L., Galli, G., Beltrame, C., Romagnani, P., Manetti, R., Romagnani, S., Maggi, E. (1999) Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J. Leukoc. Biol. 65, 691-699.
6. Panina-Bordignon, P., Papi, A., Mariani, M., Di Lucia, P., Casoni, G., Bellettato, C., Buonsanti, C., Miotto, D., Mapp, C., Villa, A., Arrigoni, G., Fabbri, L. M., Sinigaglia, F. (2001) The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J. Clin. Investig. 107, 1357-1364.
7. Sallusto, F., Mackay, C. R., Lanzavecchia, A. (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 18, 593-620.
8. Sallusto, F., Kremmer, E., Palermo, B., Hoy, A., Ponath, P., Qin, S., Forster, R., Lipp, M., Lanzavecchia, A. (1999) Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur. J. Immunol. 29, 2037-2045.
9. Campbell, J. J., Haraldsen, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, D. P., Warnke, R., Ruffing, N., Kassam, N., Wu, L., Butcher, E. C. (1999) The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400, 776-780.
10. Andrew, D. P., Ruffing, N., Kim, C. H., Miao, W., Heath, H., Li, Y., Murphy, K., Campbell, J. J., Butcher, E. C., Wu, L. (2001) C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. J. Immunol. 166, 103-111.
11. Chensue, S. W., Warmington, K., Ruth, J., Lincoln, P., Kuo, M. C., Kunkel, S. L. (1994) Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor. Am. J. Pathol. 145, 1105-1113.
12. Chensue, S. W., Warmington, K., Ruth, J. H., Lukacs, N., Kunkel, S. L. (1997) Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J. Immunol. 159, 3565-3573.
13. Ruth, J. H., Warmington, K. S., Shang, X., Lincoln, P., Evanoff, H., Kunkel, S. L., Chensue, S. W. (2000) Interleukin-4 and -13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks. Cytokine 12, 432-444.
14. Chensue, S. W., Warmington, K. S., Ruth, J. H., Lincoln, P., Kunkel, S. L. (1995) Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF. J. Immunol. 154, 5969-5976.
15. Loetscher, P., Uguccioni, M., Bordoli, L., Baggiolini, M., Moser, B., Chizzolini, C., Dayer, J. M. (1998) CCR5 is characteristic of Th1 lymphocytes. Nature 391, 344-345.
16. Campbell, J. D., HayGlass, K. T. (2000) T cell chemokine receptor expression in human Th1- and Th2-associated diseases. Arch. Immunol. Ther. Exp. (Warsz) 48, 451-456.
17. D'Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., Sinigaglia, F. (1998) Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 161, 5111-5115.
18. Zingoni, A., Soto, H., Hedrick, J. A., Stoppacciaro, A., Storlazzi, C. T., Sinigaglia, F., D'Ambrosio, D., O'Garra, A., Robinson, D., Rocchi, M., Santoni, A., Zlotnik, A., Napolitano, M. (1998) The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J. Immunol. 161, 547-551.
19. Cyster, J. G. (1999) Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102.
20. Ansel, K. M., McHeyzer-Williams, L. J., Ngo, V. N., McHeyzer-Williams, M. G., Cyster, J. G. (1999) In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190, 1123-1134.
21. Ward, S. G., Westwick, J. (1998) Chemokines: understanding their role in T-lymphocyte biology. Biochem. J. 333, 457-470.
22. Hedrick, J. A., Zlotnik, A. (1999) Chemokines and chemokine receptors in T-cell development. Chem. Immunol. 72, 57-68.
23. Rothenberg, M. E., Zimmermann, N., Mishra, A., Brandt, E., Birkenberger, L. A., Hogan, S. P., Foster, P. S. (1999) Chemokines and chemokine receptors: their role in allergic airway disease. J. Clin. Immunol. 19, 250-265.
24. Sallusto, F., Mackay, C. R., Lanzavecchia, A. (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277, 2005-2007.
25. Yamamoto, J., Adachi, Y., Onoue, Y., Adachi, Y. S., Okabe, Y., Itazawa, T., Toyoda, M., Seki, T., Morohashi, M., Matsushima, K., Miyawaki, T. (2000) Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells. J. Leukoc. Biol. 68, 568-574.
26. Iwasaki, M., Mukai, T., Nakajima, C., Yang, Y. F., Gao, P., Yamaguchi, N., Tomura, M., Fujiwara, H., Hamaoka, T. (2001) A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5. J. Immunol. 167, 6877-6883.
27. Chensue, S. W., Ruth, J. H., Warmington, K., Lincoln, P., Kunkel, S. L. (1995) In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J. Immunol. 155, 3546-3551.
28. Greaves, D. R., Wang, W., Dairaghi, D. J., Dieu, M. C., Saint-Vis, B., Franz-Bacon, K., Rossi, D., Caux, C., McClanahan, T., Gordon, S., Zlotnik, A., Schall, T. J. (1997) CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J. Exp. Med. 186, 837-844.
29. Varona, R., Zaballos, A., Gutierrez, J., Martin, P., Roncal, F., Albar, J. P., Ardavin, C., Marquez, G. (1998) Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3 alpha. FEBS Lett. 440, 188-194.
30. Liao, F., Rabin, R. L., Smith, C. S., Sharma, G., Nutman, T. B., Farber, J. M. (1999) CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J. Immunol. 162, 186-194.
31. Nanki, T., Lipsky, P. E. (2000) Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium. Arthritis Res. 2, 415-423.
32. Napolitano, M., Santoni, A. (1999) Structure and function of the CC chemokine receptor (CCR) 8. Forum (Genova) 9, 315-324.
33. Thornton, A. M., Shevach, E. M. (2000) Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 164, 183-190.
34. Schaerli, P., Willimann, K., Lang, A. B., Lipp, M., Loetscher, P., Moser, B. (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192, 1553-1562.
35. Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., Forster, R. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192, 1545-1552.
36. Ansel, K. M., Ngo, V. N., Hyman, P. L., Luther, S. A., Forster, R., Sedgwick, J. D., Browning, J. L., Lipp, M., Cyster, J. G. (2000) A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406, 309-314.
37. Chensue, S. W., Lukacs, N. W., Yang, T. Y., Shang, X., Frait, K. A., Kunkel, S. L., Kung, T., Wiekowski, M. T., Hedrick, J. A., Cook, D. N., Zingoni, A., Narula, S. K., Zlotnik, A., Barrat, F. J., O'Garra, A., Napolitano, M., Lira, S. A. (2001) Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J. Exp. Med. 193, 573-584.
38. Baba, M., Imai, T., Nishimura, M., Kakizaki, M., Takagi, S., Hieshima, K., Nomiyama, H., Yoshie, O. (1997) Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J. Biol. Chem. 272, 14893-14898.
39. Iwasaki, A., Kelsall, B. L. (2000) Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J. Exp. Med. 191, 1381-1394.
40. Krzysiek, R., Lefevre, E. A., Bernard, J., Foussat, A., Galanaud, P., Louache, F., Richard, Y. (2000) Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells. Blood 96, 2338-2345.
41. Hieshima, K., Imai, T., Opdenakker, G., Van Damme, J., Kusuda, J., Tei, H., Sakaki, Y., Takatsuki, K., Miura, R., Yoshie, O., Nomiyama, H. (1997) Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J. Biol. Chem. 272, 5846-5853.
42. Kleeff, J., Kusama, T., Rossi, D. L., Ishiwata, T., Maruyama, H., Friess, H., Buchler, M. W., Zlotnik, A., Korc, M. (1999) Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. Int. J. Cancer 81, 650-657.
43. Nakayama, T., Fujisawa, R., Yamada, H., Horikawa, T., Kawasaki, H., Hieshima, K., Izawa, D., Fujiie, S., Tezuka, T., Yoshie, O. (2001) Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int. Immunol. 13, 95-103.
44. Charbonnier, A. S., Kohrgruber, N., Kriehuber, E., Stingl, G., Rot, A., Maurer, D. (1999) Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. J. Exp. Med. 190, 1755-1768.
45. Cook, D. N., Prosser, D. M., Forster, R., Zhang, J., Kuklin, N. A., Abbondanzo, S. J., Niu, X. D., Chen, S. C., Manfra, D. J., Wiekowski, M. T., Sullivan, L. M., Smith, S. R., Greenberg, H. B., Narula, S. K., Lipp, M., Lira, S. A. (2000) CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12, 495-503.
46. Varona, R., Villares, R., Carramolino, L., Goya, I., Zaballos, A., Gutierrez, J., Torres, M., Martinez, A. C., Marquez, G. (2001) CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J. Clin. Investig. 107, R37-R45.
47. Fitzhugh, D. J., Naik, S., Caughman, S. W., Hwang, S. T. (2000) Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro. J. Immunol. 165, 6677-6681.
48. Homey, B., Dieu-Nosjean, M. C., Wiesenborn, A., Massacrier, C., Pin, J. J., Oldham, E., Catron, D., Buchanan, M. E., Muller, A., deWaal Malefyt, R., Deng, G., Orozco, R., Ruzicka, T., Lehmann, P., Lebecque, S., Caux, C., Zlotnik, A. (2000) Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164, 6621-6632.
49. Qiu, B., Frait, K. A., Reich, F., Komuniecki, E., Chensue, S. W. (2001) Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Am. J. Pathol. 158, 1503-1515.
50. Yoneyama, H., Harada, A., Imai, T., Baba, M., Yoshie, O., Zhang, Y., Higashi, H., Murai, M., Asakura, H., Matsushima, K. (1998) Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J. Clin. Investig. 102, 1933-1941.
51. Kim, C. H., Rott, L., Kunkel, E. J., Genovese, M. C., Andrew, D. P., Wu, L., Butcher, E. C. (2001) Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Investig. 108, 1331-1339.