Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 inhibitors. Part II: Replacing the heterocycle

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 1, 1996, Pages 87-92

  Gauthier, Jacques Yves ^a   Leblanc, Yves ^a   Black, W Cameron ^a   Chan, Chi Chung ^a   Cromlish, Wanda A ^a   Gordon, Robert ^a   Kennedey, Brian P ^a   Lau, Cheuk K ^a   Léger, Serge ^a   Wang, Zhaoyin ^a   Ethier, Diane ^a   Guay, Jocelyne ^a   Mancini, Joseph ^a   Riendeau, Denis ^a   Tagari, Philip ^a   Vickers, Philip ^a   Wong, Elizabeth ^a   Xu, Lijing ^a   Prasit, Peptiboon ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 THIADIAZOLE DERIVATIVE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CYCLOOXYGENASE 2; INDOMETACIN; ISOENZYME; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; THIADIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; ORAL DRUG ADMINISTRATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; ULCEROGENESIS;

ANIMALIA;

EID: 0030029368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00564-A     Document Type: Article

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