Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: Separation of blood volume and magnetic susceptibility effects

Magnetic Resonance in Medicine

Volumn 37, Issue 6, 1997, Pages 953-956

  Kennan, Richard P ^a   Scanley, B Ellen ^b   Gore, John C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Blood volume; Hypoxia; Susceptibility

Indexed keywords

HEMODYNAMICS; MAGNETIC SUSCEPTIBILITY; MAGNETISM; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN;

BLOOD OXYGENATION; BLOOD VOLUMES; BOLD EFFECTS; CONTRAST AGENT; HYPOXIA; INDUCED SIGNAL; SIGNAL CHANGES; SIGNAL VARIATIONS;

BLOOD;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN HYPOXIA; HYPEROXIA; HYPOXIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SIGNAL PROCESSING;

EID: 0030980256     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910370621     Document Type: Article

References (25)

1. S. Ogawa, T. M. Lee, A. S. Nayak, P. Glynn, Oxygenation sensitive contrast in magnetic resonance imaging of rodent brain at high magnetic fields. Magn. Reson. Med. 14, 68-78 (1990).
2. 2* and resonance frequency weighted magnetic resonance images of rodent tumours. NMR Biomed. 7, 3-11 (1994).
3. 2* weighted images during hyperoxia diffentiate tumors from normal tissue. Magn. Reson. Med. 33, 318-325 (1995).
4. E. Rostrup, H. B. W. Larrson, P. B. Toft, K. Garde, O. Henriksen, Signal changes in gradient echo images of human brain induced by hypo- and hyperoxia. NMR Biomed. 8, 41-47 (1995)
5. 2 induced increase in cerebral perfusion. NMR Biomed. 7, 29-34 (1994).
6. F. Prielmeir, Y. Nagatomo, J. Frahm. Cerebral blood oxygenation in rat brain during hypoxic hypoxia: quantitaive MRI of effective relaxation rates. Magn. Reson. Med. 31, 678-681 (1994).
7. B. E. Hoppel, R. M. Weiskopf, K. R. Thulborn, J. B. Moure, K. K. Kwong, B. R.Rosen, Measurement of regional blood oxygenation and cerebral hemodynamics. Magn. Reson. Med. 30, 715-723 (1993).
8. 2. Magn. Reson. Med. 33, 448-452 (1995).
9. B. R. Rosen, J. W. Belliveau, J. M. Vevea, T. J. Brady, Perfusion imaging with NMR contrast agent, Magn. Reson. Med 14, 249-265 (1990).
10. D. A. Yablonkiy, E. M. Haacke, Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime. Magn. Reson. Med. 32, 749-763 (1994).
11. R. P. Kennan, J. Zhong. J. C. Gore. Intravascular susceptibility contrast mechanisms in tissue. Magn. Reson. Med. 31, 9-31 (1994).
12. R. Menon. X. Hu, G. Adriany, P. Andersen, S. Ogawa, K. Ugurbil, in "Proc., SMRM, 2nd Annual Meeting, San Francisco, 1994," p. 622.
13. S. Ogawa, T. M. Lee, B. Barrere, The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation. Magn. Reson. Med. 29, 205-210 (1993).
14. J. L. Boxerman, P. A. Bandettini, K. K. Kwong, J. R. Baker. T. L. Davis, B. R. Rosen, R. M. Weiskopf, The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn. Reson. Med. 34, 4-10 (1995).
15. J. K. Becconsall, G. Doyle Daves, W. R. Anderson, Reference independent nuclear magnetic: resonance solvent shifts. J. Am. Chem. Soc. 92, 430-433 (1970).
16. H. Nakagawa, S. Z. Lin, D. Berczki, G. Geszteyi, T. Otsuka, L. Wei, F. J. Hans, V. R. Acuff. J. L. Chem, K. D. Pettigrew, C. S. Patlak, R. G. Blasberg, J. D. Fenstermacher, Blood volumes, hematocrits, and transit times in parenchymal microvascular systems of the rat brain, in "Diffusion and Perfusion Magnetic Resonance Imaging" (D. LeBihan, Ed.), pp. 193-200, Raven Press, New York, 1995.
17. .R. Thulborn, J. C. Waterton, P. M. Mathews, G. Radda, Oxygenation dependence of the transverse relaxation times of water protons in whole blood at high field. Biochim. Biophys. Acta 714, 265-270 (1982).
18. K. K. Kwong, K. M. Donahue, L. Ostergaard, T. Shen. P. A. Bandettini, I. Wanke, J. Moore, B. R. Rosen, Mechanism of MR brain signal increase in hyperoxia, in "Proc., SMRM, 3rd Annual Meeting.,Nice, France, 1995," p. 768.
19. P. Jezzard, F. Heineman, J. Taylor, D. DePres, H. Wen, R. S. Balaban, R. Turner, Comparison of EPI gradient echo contrast changes in cat brain caused by respiratory challenges with direct simultaneous measurement of cerebral oxygenation via a cranial window. NMR Biomed. 7, 35-44 (1994).
20. D. Bereczki, L.Wei, T. Otsuka, V. Acuff, K. Pettigrew, C. Patlak, J. Fenstermacher, Hypoxia increases velocity of blood flow through parenchymal microvascular systems in rat brain. J. Cereb. Blood Flow Metab. 13, 475-486 (1993).
21. E. Francois-Dainville, E. Buchweitz, H. R. Weiss, Effects of hypoxia on percent of arteriolar and capillary beds perfused in the rat brain. J. Appl. Physiol. 60, 280-288 (1986).
22. R. P. Shockley, J. C. LaManna, Determination of rat cerbral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation. Brain Res. 454, 170-178 (1988).
23. M. Cavazzuti, C. A. Porro, G. P. Biral, C. Benassi, G. C. Barbieri, Ketamine effects on local cerebral blood flow and metabolism in rat. J. Cereb. Blood Flow Metab. 7, 806-811 (1987).
24. J. W. Belliveau, D. N. Kennedy, R. C. Mckinstry, B. R. Buchbinder, R. M. Weiskopf, M. S. Cohen, J, M. Vevea, T. J. Brady, B. R. Rosen, Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254, 716-719 (1991).
25. K. M. lohnson. J. Z. Tao, R. P. Kennan, J. C. Gore, in "Proc., SMRM, 3rd Annual Meeting, Nice. France, 1995," p. 1118.