Effect of carbogen breathing on tumour microregional blood flow in humans

Radiotherapy and Oncology

Volumn 41, Issue 3, 1996, Pages 225-231

  Powell, Melanie E B ^a   Hill, Sally A ^b   Saunders, Michele I ^a   Hoskin, Peter J ^a   Chaplin, David J ^b  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Carbogen; Laser Doppler flowmetry (LDF); Microregional tumour perfusion

Indexed keywords

CARBOGEN;

ADULT; AGED; ARTICLE; BREATHING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MALE; PRIORITY JOURNAL; RADIOSENSITIZATION; TUMOR BLOOD FLOW;

ADMINISTRATION, INHALATION; AGED; AGED, 80 AND OVER; CARBON DIOXIDE; FEMALE; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MIDDLE AGED; NEOPLASMS; OXYGEN; PERFUSION; RADIATION-SENSITIZING AGENTS; REGIONAL BLOOD FLOW;

EID: 0030448969     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(96)01833-6     Document Type: Article

References (25)

1. [1] Abbot, N.C. and Beck, J.S. Biological zero in laser Doppler measurements in normal ischaemic and inflamed human skin. Int. J. Microcirc. Clin. Exp. 12: 89-98, 1993.
2. [2] Chaplin, D.J. and Hill, S.A. Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br. J. Cancer 71: 1210-1213, 1995.
3. [3] Chaplin, D.J., Horsman, M.R. and Sieman, D.W. Further evaluation of nicotinamide and carbogen as a strategy to re-oxygenate hypoxic cells in vivo importance of nicotinamide dose and pre-irradiation breathing time. Br. J. Cancer 68: 269-273, 1993.
4. [4] Chaplin, D.J., Olive, P.L. and Durand, R.E. Intermittent blood flow in the murine tumour: radiobiological effects. Cancer. Res. 47: 597-601, 1987.
5. [5] Chen, J.L., Wei, L., Acuff, V., Bereczki, D., Hans, F.J., Otsukat, T., Finnegan, W., Patrak, C. and Feinstermacher, J. Slightly altered permeability-surface area products imply some cerebral capillary recruitment during hypercapnia. Microvasc. Res. 48: 190-211, 1994.
6. [6] Colantuoni, A., Bertuglia, S. and Intaglietta, M. A biological zero of laser Doppler fluxmetry - microcirculatory correlates in the hamster cheek pouch during flow and no flow conditions. Int. J. Microcirc. Clin. Exp. 13: 125-136, 1993.
7. [7] Dewhirst, M.W., Ong, E.T., Rosner G.L., Rehmus S.W., Shan, S., Braun, R.D., Brizel, D.M. and Secomb, T.W. Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.. Br. J. Cancer 74: 241-246, 1996.
8. [8] Dische, S., Rojas, A., Rugg, T., Hong, A. and Michael, B.D. Carbogen breathing: a system for use in man. Br. J. Radiol. 65: 87-90, 1992.
9. 2 histography. Br. J. Cancer 56: 919-924, 1992.
10. [10] Grau, R.S., Horsman, M.R. and Overgaard, J. Improving the radiation response in a C3H mouse mammary carcinoma by normobaric oxygen or carbogen breathing. Int. J. Radiat. Oncol. Biol. Phys. 22: 415-419, 1995.
11. [11] Hill, S.A., Pigott, K.H., Saunders, M.I., Powell, M.E.B., Arnold, S., Obeid, A., Ward, G., Leehey, M., Hoskin, P.J. and Chaplin, D.J. Microregional blood flow fluctuations in murine and human tumours assessed using laser Doppler microprobes. Br. J. Cancer 74: 260-263, 1996.
12. [12] Honess, D.J. and Bleehan, N.M. Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined. Br. J. Cancer 71: 1175-1180, 1995.
13. [13] Kruuv, J.A., Inch, W.R. and McCredie, J.A. Blood flow and oxygenation of tumors in mice. Cancer 20: 51-58, 1967.
14. [14] Oberg, P.A. Laser-Doppler flowmetry. Crit. Rev. Biomed. Eng. 18: 125-163, 1990.
15. [15] Overgaard, J. Modification of hypoxia from Gottwals Schwarz to nicotinamide: have we learned the lesson? In: Danish Cancer Society. Progress in Radio-Oncology V, pp. 469-475. Editors: H.D. Kogelnik. Monduzzi Editore, Bologna, 1995.
16. [16] Pigott, K.H., Hill, S.A., Chaplin, D.J. and Saunders, M.I. Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry. Radiother. Oncol. 40: 45-50, 1996.
17. [17] Rider, W.D., Kersesteci, A.G., Hawkins, N.V. and Bush, R.S. A trial of 'orthobaric oxygen' as an adjunct of radiotherapy of bladder cancer. In: Proceedings of Radiological Society of North America, 5th Scientific Assembly, Chicago, 1969.
18. [18] Robinson, S.P., Howe, F.A., Griffiths, J.R. Non-invasive monitoring of carbogen-induced changes in tumor, blood flow and oxygenation by functional magnetic resonance imaging. Int. J. Radiat. Oncol. Biol. Phys. 33: 855-859, 1995.
19. [19] Rojas, A. Radiosensitisation with normobaric oxygen and carbogen. Radiother. Oncol. 20: 65-70, 1991.
20. [20] Rubin, P., Hanley, J., Keys, H.M., Marcial, V. and Brady, L. Carbogen breathing during radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 5: 1963-1970, 1979.
21. 2) on the in vivo radiation response of a murine sarcoma. Int. J. Radiat. Oncol. Biol. Phys. 2: 903-911, 1977.
22. [22] Siemann, D.W., Horsman, M.R. and Chaplin, D.J. The radiation response of KHT sarcomas following nicotinamide treatment and carbogen breathing. Radiother. Oncol. 31: 117-122, 1994.
23. [23] Taylor, N.J., Griffiths, J.R. Howe, F.A., Saunders, M.I., Robinson, S.P., Thoumine, M., Caine, L.A., Hoskin, P.J., Powell, M., Chaplin, D.J. and Baddeley, H. Carbogen-induced oxygenation and blood flow changes within human tumours, monitored by Gradient Echo Magnetic Resonance Imaging. In: SMRM 4th Fourth Annual Meeting, p. 1313, 1996 (Abstract).
24. [24] Thomlinson, R.H. and Gray, L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer 9: 539-549, 1955.
25. [25] Trotter, M.J., Chaplin, D.J., Durand, R.E. and Olive, P.L. The use of fluorescent probes to identify regions of transient perfusion in murine tumours. Int. J. Radiat. Oncol. Biol. Phys. 16: 931-935, 1989.