The effect of hypoxia and hyperoxia on nucleoside triphosphate/inorganic phosphate, pO2 and radiation response in an experimental tumour model

British Journal of Cancer

Volumn 76, Issue 11, 1997, Pages 1432-1439

  Nordsmark, M ^a   Maxwell, R J ^a   Horsman, M R ^a   Bentzen, S M ^a   Overgaard, J ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

31P NMR spectroscopy; C3H mammary carcinoma; Hyperoxia; Hypoxia; NTP P(i); Polarographic oxygen electrode; Radiation response; Tumour oxygenation

Indexed keywords

CARBOGEN; CARBON MONOXIDE; NUCLEOSIDE TRIPHOSPHATE; OXYGEN; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; BREAST CARCINOMA; CANCER MODEL; CONTROLLED STUDY; HYPEROXIA; HYPOXIA; MALE; MOUSE; NONHUMAN; OXYGEN BREATHING; OXYGEN TENSION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POLAROGRAPHY; PRIORITY JOURNAL; RADIOSENSITIVITY; STATISTICAL ANALYSIS; TISSUE OXYGENATION;

EID: 0030727440     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.575     Document Type: Article

References (45)

1. Brizel D, Lin S, Johnson JL, Brooks J, Dewhirst MW and Piantadosi CA (1995) The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. Br J Cancer 72: 1120-1124
2. Brizel D, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz and Dewhirst MW (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943
3. Chaplin DJ, Horsman MR and Siemann DW (1993) Further evaluation of nicotinamide and carbogen as a strategy to reoxygenate hypoxic cells in vivo: importance of nicotinamide dose and pre-irradiation breathing time. Br J Cancer 68: 269-273
4. Dixon WJ (1990) BMDP Statistical Software Manual, Vol. 2, pp. 1135-1155. University of California Press: Berkely, CA
5. Durand RE (1991) Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. Int J Radiat Oncol Biol Phys 20: 253-258
6. Falk SJ, Ward R and Bleehen NM (1992) The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerized pO2 histography. Br J Cancer 66: 919-924
7. Gatenby RA, Kessler HB, Rosenblum JS et al (1988). Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14: 831-838
8. Gerweck LE, Seneviratne T and Gerweck KK (1993) Energy status and radiobiological hypoxia at specified oxygen concentrations. Radiat Res 135: 69-74
9. Gerweck LE, Koutcher J and Zaidi ST (1995) Energy status parameters, hypoxia fraction and radiocurability across tumor types. Acta Oncol 34: 335-338
10. Grau C and Overguaard J (1988) Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay. Radiother Oncol 13: 301-309
11. Grau C, Horsman MR and Overgaard J (1992) Improving the radiation response in a C3H mouse mammary carcinoma by normobaric oxygen or carbogen breathing, Int J Radiat Oncol Biol Phys 22: 415-419
12. Grau C, Khalil AA, Nordsmark M, Horsman MR and Overgaard J (1994) The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo. Br J Cancer 69: 50-57
13. Horsman MR, Khalil AA, Nordsmark M, Grau C, Overgaard J (1993) Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model. Radiother Oncol 28: 69-71
14. Horsman MR, Siemann DW, Nordsmark M, Khalil AA, Overgaard J and Chaplin DJ (1994) The combination of nicotinamide and carbogen breathing to improve tumour oxygenation prior to radiation treatment. Adv Exp Med Biol 361: 635-642
15. Horsman MR, Khalil AA, Nordsmark M et al (1995) The use of oxygen electrodes to predict radiobiological hypoxia in tumors. In Tumor Oxygenation. Vaupel PW, Kelleher DK and Günderoth M (eds), pp. 49-57. Gustav Fischer: Stuttgart
16. Höckel M, Schlenger K, Aral B, Mitze M, Schäffer U and Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515
17. Kallinowski F, Zander R, Höckel, M and Vaupel P (1990) Tumour tissue oxygenation as evaluated by computerized-pO2-histography. Int J Radiat Oncol Biol Phys 19: 953-961
18. Karezmar G, Arbeit JM, Toy BJ, Speder A and Weiner MW (1992) Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy. Cancer Res 52: 71-76
19. Kolstad P (1968) Vascularization, oxygen tension, and radiocurability in cancer of the cervix. Norwegian Monographs on Medical Science. Scandinavian University Books: Oslo
20. Lyng H, Olsen DR, Southon TE and Rofstad EK (1993) 31P-nuclear magnetic resonance spectroscopy in vivo of six human melanoma xenograft lines: tumour bioenergetic status and blood supply. Br J Cancer 68: 1061-1070
21. McCain DC (1987) 31P nuclear spin relaxation. In Phosphorus NMR in biology. Burt CT (ed). pp. 25-61. CRC Press: Boca Raton, FL
22. Martin L, Lartigau E, Weeger P et al (1993) Changes in the oxygenation of head and neck tumors during carbogen breathing. Radiother Oncol 27: 123-130
23. Moulder JE and Rockwell S (1984) Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10: 695-712
24. Nordsmark M, Grau C, Horsman MR, Jörgensen HS and Overgaard J (1995) Relationship between tumour oxygenation, bioenergetic status and radiobiological hypoxia in an experimental model. Acta Oncol 34: 329-334
25. Nordsmark M, Overgaard M and Overgaard J (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39
26. Okunieff PG, Koulcher JA, Gerweck L, McFarland E, Hitzig B, Urano M, Brady T, Neuringer L and Suit HD (1986) Tumor size dependent changes in a murine fibrosarcoma: Use of in vivo 31P NMR for non-invasive evaluation of tumor metabolic status. Int J Radiat Oncol Biol Phys 12: 793-799
27. Okunieff P, McFarland E, Rummeny E, Willett C, Hitzig B, Neuringer L and Suit H (1987) Effects of oxygen on the metabolism of murine tumors using in vivo phosphorus-31 NMR. Amer J Clin Oncol 10: 475-482
28. Okunieff P, Ramsay J, Tokuhiro T, Hitzig B, Rummeny E, McFarland E. Neuringer LJ and Suit H (1988) Estimation of tumor oxygenation and metabolic rate using 31P MRS: Correlation of longitudinal relaxation with tumor growth rate and DNA synthesis. Int J Radiat Oncol Biol Phys 14: 1185-1195
29. Olsen DR, Lyng H, Southon TE and Rofstad EK (1994) 31P-nuclear magnetic resonance spectroscopy in vivo of four human melanoma xenograft lines: spinlattice relaxation times. Radiother Oncol 32: 54-62
30. Olsen DR, Lyng H, Petersen S and Rofstad FK (1995) Spin-lattice relaxation time of inorganic phosphate in human tumor xenografts measured in vivo by 31P-magnetic resonance spectroscopy. Influence of oxygen tension. Acta Oncol 34: 339-343
31. Overgaard J (1980) Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue. Br J Cancer 41: 10-21
32. Overgaard J and Horsman MR (1996) Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Sem Rad Oncol 6: 10-21
33. Raleigh JA, Dewhirst MW and Thrall DE (1996) Measuring tumor hypoxia. Sem Rad Oncol 6: 37-45
34. Rofstad EK, Fenton BM and Sutherland RM (1988a) Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: Relationship to tumour volume, tumour pH and fraction of radiobiologically hypoxic cells. Br J Cancer 57: 494-502
35. Rofstad EK, DeMuth P, Fenton BM and Sutherland RM (1988b) 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res 48: 5440-5446
36. Rubin P, Hanley J, Keys HM, Marcial V and Brady L (1979) Carbogen breathing during radiation therapy. The radiation therapy oncology group study. Int J Radial Oncol Biol Phys 5: 1963-1970
37. 2) on the in vivo radiation response of a murine sarcoma. Int J Radiat Oncol Biol Phys 2: 903-911
38. Sostman HD, Rockwell S, Sylvia AL et al (1991) Evaluation of BA1112 Rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy. Magnetic Reson Med 20: 253-267
39. Stone HB, Brown MJ, Phillips TL, Sutherland RM (1993) Oxygenation in Human Tumors: Correlation between Methods of Measurement and Response to Therapy. Radiat Res 136: 422-434
40. Teicher BA, Lazo JS and Sartorelli AC (1981) Classification of antineoplastic agents by their selective toxicities towards oxygenated and hypoxic cells. Cancer Res 41:73-81
41. Van Den Boogart A, Howe FA, Rodrigues LM Stubbs M and Griffiths Jr (1995) In vivo 31P MRS: Absolute concentrations, signal-to-noise and prior knowledge. NMR Biomed 8: 87-93
42. Van Der Veen JW, de Beer R, Luyten PR and van Ormondt D (1988) Accurate quantification of in vivo 31P NMR signals using the variable projection method and prior knowledge. Magnetic Reson Med 6: 92-98
43. 2 tension measurements in a murine fibrosarcoma. Radiat Res 120: 477-493
44. Vaupel P, Okunieff P and Neuringer LJ (1990) In vivo 31P-NMR spectroscopy of murine tumours before and after localized hyperthermia. Int J Hyperthermia 6: 15-31
45. Vaupel P, Kelleher DK and Engel T (1994a) Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour. Br J Cancer 69: 46-49