Mapping pathophysiological features of breast tumors by MRI at high spatial resolution

Nature Medicine

Volumn 3, Issue 7, 1997, Pages 780-782

  Degani, Hadassa ^a   Gusis, Vadim ^a   Weinstein, Daphna ^a   Fields, Scott ^b   Strano, Shalom ^c  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c KAPLAN HOSPITAL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; BREAST TUMOR; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; HUMAN; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ANIMALS; BREAST NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION;

EID: 0030795378     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0797-780     Document Type: Article

References (23)

1. Harms, S.E. & Flaming, D.P. MR imaging of the breast. J. Magn. Reson. Imaging 3, 277-283 (1993).
2. Heywang-Kobrunner, S.H. Contrast-enhanced magnetic resonance imaging of the breast. Invest. Radiol. 29, 94-104 (1994).
3. Kaiser, W.A. & Zeitler, E. MR imaging of the breast: Fast imaging sequences with and without Gd-DTPA. Radiology 170, 681-686 (1989).
4. Furman-Haran, E., Margalit, R., Maretzek, A.F. & Degani, H. Angiogenic response of MCF7 human breast cancer to hormonal treatment: Assessment by dynamic GdDTPA-enhanced MRI at high spatial resolution. J. Magn. Reson. Imaging 6, 195-202 (1996).
5. Furman-Haran, E., Margalit, R., Grobgeld, D. & Degani, H. Dynamic contrast enhanced magnetic resonance imaging reveals stress induced angiogenesis in MCF7 human breast tumors. Proc. Natl. Acad. Sci. USA 93, 6247-6251 (1996).
6. Frouge, C., Guinebretiere, J.-M., Contesso, G., DiPaola, R. & Blery, M. Correlation between contrast enhancement in dynamic magnetic resonance imaging of the breast and tumour angiogenesis. Invest. Radiol. 29, 1043-1049 (1994).
7. Buckley, D.L., Kerslake, R.W., Blackband, S.J. & Horsman, A. Quantitative analysis of multislice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure. Magn. Reson. Med. 32, 646-65 (1994).
8. Hoffmann, U., Brix, C., Knopp, M.V., Heb, T. & Lorenz, W.J. Pharmacokinetic mapping of the breast: A new method for dynamic MR mammography. Magn. Reson. Med. 33, 506-514 (1995).
9. Hulka, C.A. et al. Benign and malignant breast lesions: Differentiation with echoplanar MR imaging. Radiology 197, 33-38 (1995).
10. Tofts, P.S., Berkowitz, B. & Schnall, M.D. Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumours using a permeability model. Magn. Reson. Med. 33, 564-568 (1995).
11. Lucas-Qesada, F.A., Sinha, U. & Sinha, S. Segmentation strategies for breast tumors from dynamic MR images. J. Magn. Reson. Imaging 6, 753-763 (1996).
12. Keltz, F., Santyr, G.E., Cron, G.O. & Mongin, S.J. Application of a quantitative model to differentiate benign from malignant breast lesions detected by dynamic, gadolinium-enhanced MRI. J. Magn. Reson. Imaging 6, 743-752 (1996).
13. Larsson, H.B.W. et al. Quantification of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn. Reson. Med. 16, 117-131 (1990).
14. Brix, G. et al. Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J. Computer Assisted Tomogr. 15, 621-628 (1991).
15. Tofts, P.S. & Kermode, A.G. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn. Reson. Med. 17, 357-367 (1991).
16. Furman, E., Margalit, R., Bendel, P., Horowitz, A. & Degani, H. In vivo studies by magnetic resonance imaging and spectroscopy of the response to tamoxifen of MCF7 human breast cancer implanted in nude mice. Cancer Commun. 3, 287-297 (1991).
17. Folkman, J. Tumor angiogenesis. Advances Cancer Res. 43, 175-203 (1985).
18. Weidner, N., Semple, J.P., Wilch, W.R. & Folkman, J. Tumor angiogenesis and metastasis: Correlation in invasive breast carcinoma. N. Engl. J. Med. 324, 1-8 (1991).
19. Weidner, N. et al. Tumour angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. 84, 1875-1887 (1992).
20. Degani, H. et al. Evaluation of breast cancer therapy with contrast enhanced MRI at high spatial resolution. J. Magn. Reson. Imaging 4, 116 (1994).
21. Weidmann, H.J., Laniado, M. & Mutzel, W. Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol. Chem. Phys. Med. NMR 16, 167-172 (1984).
22. Poon, C.S., Bronskill, M.J., Hemkelman, R.M. & Boyd, N.F. Quantitative magnetic resonance imaging parameters and their relationship to mammographic pattern. J. Natl. Cancer Inst. 84, 777-781 (1992).
23. Lauffer, R.B. Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: Theory and design. Chem. Rev. 87, 901-927 (1987).