Antigen loading of MHC class I molecules in the endocytic tract

Traffic

Volumn 2, Issue 2, 2001, Pages 124-137

  Kleijmeer, Monique J ^a   Escola, Jean Michel ^b   Uytdehaag, Fons G C M ^c   Jakobson, Eva ^d   Griffith, Janice M ^a   Osterhaus, Albert D M E ^e   Stoorvogel, Willem ^a   Melief, Cornelis J M ^f   Rabouille, Catherine ^g   Geuze, Hans J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Department of Biochemistry Sciences II ^*  (Switzerland)

^c CRUCELL HOLLAND BV   (Netherlands)

^d KAROLINSKA INSTITUTE   (Sweden)

^e ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

B cells; Dendritic cells; Endosomes; Exosomes; MHC class I

Indexed keywords

AMMONIUM CHLORIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIRUS PROTEIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOBLAST; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; LYSOSOME; MEASLES VIRUS; MEMBRANE FUSION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TRANSPORT; T LYMPHOCYTE ACTIVATION;

AMMONIUM CHLORIDE; ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; B-LYMPHOCYTES; DENDRITIC CELLS; ENDOCYTOSIS; ENDOSOMES; EXOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOBLOTTING; MEASLES VIRUS; PROTEIN TRANSPORT; T-LYMPHOCYTES, CYTOTOXIC; VIRAL FUSION PROTEINS;

EID: 0035109189     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.020207.x     Document Type: Article

References (69)

1. Antigen recognition by class I-restricted T lymphocytes
2. The biochemistry and cell biology of antigen processing and presentation
3. How MHC class II molecules acquire peptidecargo: Biosynthesis and trafficking through the endocytic pathway
4. Inhibitors of the proteasome block non-lysosomal degradation and the generation of peptides presented on MHC-class I molecules
5. Sequences encoded in the class II region of the MHC related to the "ABC" Superfamily of transporters
6. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer
7. Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi
8. Capture and processing of exogenous antigens for presentation on MHC molecules
9. Assembly, transport, and function of MHC class II molecules
10. The role of endosomes and lysosomes in MHC class II functioning
11. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
12. MHC class II compartments represent conventional endocytic compartments in human and mouse B lymphoblasts
13. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
14. Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells
15. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple endocytic compartments
16. MHC class I-restricted CTL responses to exogenous antigens
17. A new foreign policy: MHC class I molecules monitor the outside world
18. + T cell responses to infectious agents, tumors, transplants and vaccines
19. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
20. Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis
21. Phagocyte-induced antigen-specific activation of unprimed CD8 + T cells in vitro
22. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
23. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
24. Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages
25. b
26. Hepatitis B virus small surface antigen particles are processed in a novel endosomal pathway for major histocompatibility complex class I-restricted epitope presentation
27. TAP1-independent loading of class I molecules by exogenous viral proteins
28. Recycling MHC class I molecules and endosomal peptide loading
29. B lymphocytes secrete antigen presenting vesicles
30. F.G.C.M. Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA-class 1- and HLA-class II-restricted cytotoxic T cell recognition
31. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells
32. Paramyxoviridae: The viruses and their replication
33. Measles virus
34. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
35. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
36. Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: Demonstration of a pathway for receptor shedding
37. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
38. The tetraspan protein CD82 is a resident of MHC class II compartments (MIICs) where it associates with HLA-DR, DM and DO molecules
39. Molecular characterization of dendritic cell-derived exosomes: Selective accumulation of the heat shock protein hsc73
40. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
41. Production of monoclonal antibodies to group A erythrocytes, HLA and other cell surface antigens: New tools for genetic analysis
42. Dendritic cells and the control of immunity
43. Proliferating dendritic cell progenitors in human blood
44. Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation
45. Heat-inactivated Sendai virus can enter multiple MHC class I processing pathways and generate cytotoxic T lymphocyte responses in vivo
46. Presentation of an exogenous antigen by major histocompatibility complex class I molecules
47. TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells
48. Bacterial proteins can be processed by macrophages in a transporter associated with antigen processing-independent, cysteine protease-dependent manner for presentation by MHC class I molecules
49. Regulation of MHC class I synthesis and expression by human neutrophils
50. Association of the invariant chain with major histocompatibility complex class I molecules directs trafficking to endocytic compartments
51. Invariant chain association with MHC class I: Preference for HLA class I beta 2-microglobulin heterodimers, specificity and influence of the MHC peptide-binding groove
52. Spontaneous internalization of class I major histocompatibility complex molecules in T lymphoid cells
53. Endocytosis of MHC molecules by B cell-B lymphoma and B cell-T lymphoma hybrids
54. Receptor-like nature of class I HLA: Endocytosis via coated pits
55. Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules
56. Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments
57. Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation
58. Cross-priming for a secondary response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
59. Induction of H-2-restricted cytotoxic T cells: In vivo induction has the appearance of being unrestricted
60. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
61. Helper activity is required for the in vivo generation of cytotxic T lymphocytes
62. T help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
63. - T-helper and a T-killer cell
64. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
65. Receptor-mediated endocytosis of heat-shock proteins by professional antigen presenting cells
66. A subset of HLA-B27 molecules contains peptides much longer than non-amers
67. Defective processing and presentation of exogenous antigens in mutants with normal class II genes
68. Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells
69. Immunogold labeling of ultrathin cryosections: Application in immunology