Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections

Biology of the Neonate

Volumn 74, Issue 2, 1998, Pages 143-162

  Peterson, Jerry A ^a   Patton, Stuart ^b   Hamosh, Margit ^c  

^a Cancer Res Inst of Contra Costa   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Butyrophilin; Glycoaminoglycans; Lactadherin; MUC 1 mucin; Oligosaccharides

Indexed keywords

ANTIINFECTIVE AGENT; BUTYROPHILLIN; CD4 ANTIGEN; GLYCOPROTEIN GP 120; GLYCOSAMINOGLYCAN; LACTADHERIN; MILK FAT; MUCIN; OLIGOSACCHARIDE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

BREAST MILK; EPITHELIUM CELL; ESCHERICHIA COLI; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INFANT NUTRITION; INFECTION PREVENTION; NEWBORN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; REVIEW; ROTAVIRUS; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIGENS, SURFACE; BACTERIAL INFECTIONS; FEMALE; GLYCOLIPIDS; GLYCOPROTEINS; HUMANS; INFANT, NEWBORN; MILK PROTEINS; MILK, HUMAN; MOLECULAR SEQUENCE DATA; MUCINS; VIRUS DISEASES;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS; ROTAVIRUS;

EID: 0031844095     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000014020     Document Type: Review

References (65)

1. Patton S, Keenan T: The milk fat globule membrane. Biochim Biophys Acta 1975;415:273-309.
2. Mather IH: Proteins of the milk-fat-globule-membrane as markers of mammary epithelial cell and apical plasma membrane; in Neville MC, Daniel CW (eds): The Mammary Gland: Development, Regulation, and Function. New York, Plenum, Publishing, 1987, pp 217-267.
3. Patton S, Gendler SJ. Spicer AP: The epithelial mucin, MUC-1, of milk, mammary gland and other tissues. Biochim Biophys Acta 1995; 1241.407-424.
4. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D: Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 1990;265:15286-15293.
5. Shimizu M, Yamauchi K: Isolation and characterization of mucin-like glycoprotein in human milk fat globule membrane. J Biochem 1982;91: 515-524.
6. Hanisch FG, Uhlenbruck G, Peter-Katalmic J, Egge H, Dabrowski J. Dabrowski U: Structures of neural O-linked polylactosaminoglycans on human skim milk mucins: A novel type of linearly extended poly-N-acetyllactosamme backbones with Gal beta(1-4)GlcNAc beta(1-6) repeating units. J Biol Chem 1989; 264:872-883.
7. Snow LD, Colton DG, Carraway KL: Purification and properties of the major sialogiycoprotein of the milk fat globule membrane. Arch Biochem Biophys 1977;179:690-697.
8. Gendler SJ, Lancaster CA, Taylor-Papadimitnou J, Duhig T, Peat N, Burchell JM, Pemberton L, Lalani EN, Wilson D: Molecular cloning and expression of human tumorassociated polymorphic epithelial mucin. J Biol Chem 1990;265: 15286-15293.
9. Carvalho F, Seruca R, David L, Amorim A, Seixas M, Bennett E, Clausen H, Sobrinho-Simoes M: MUC1 gene polymorphism and gastric cancer: An epidemiological study. Glycoconj J 1997;14:107-111.
10. Buchheim W, Welsch U, Patton S: Electron microscopy and carbohydrate histochemistry of the human milk fat globule membrane; in Hanson LA (ed): Biology of Human Milk. New York, Raven Press, 1988, pp 27-44.
11. Buchheim W, Welsch U, Huston G, Patton S: Glycoprotein filament removal from human milk fat globules by heat treatment. Pediatrics 1987; 91:141-146.
12. Welsch U, Buchheim W, Schumacher U, Schinko I, Patton S: Structural, histochemical, and biochemical observations on horse milk fat globule membranes and casein micelles. Histochemistry 1988;88:357-365.
13. Patton S, Patton RS: Genetic polymorphism of PAS-I, the mucin-like glycoprotein of bovine milk fat globule membrane, J Dairy Sci 1990;73: 3567-3574.
14. Huott ML, Josephson RV, Hens JR, Rogers GW, Patton S: Polymorphic forms of the epithelial mucin, PAS-I (MUC1), in milk of Holstein cows (Bos taurus), Comp Biochem Physiol [B] 1995;111:559-565.
15. Campana WM, Josephson RV, Patton S: Presence and genetic polymorphism of an epithelial mucin in milk of the goat (Capra hircus). Comp Biochem Physiol [B] 1992; 103:261-266.
16. Pimentai RA, Julian J, Gendler SJ, Carson DD: Synthesis and intracellular trafficking of Muc-1 and mucins by polarized mouse uterine epithelial cells. J Biol Chem 1996;271: 28128-28137.
17. Patton S, Huston GE: A method for isolation of milk fat globules. Lipids 1986;21:170-174.
18. Spicer AP, Rowse GJ, Lidner TK, Gendler SJ: Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 1995;270:30093-30101.
19. Rossi EA, McNeer RR, Price-Schiavi SA, Van den Brande JMH, Komatsu M, Thompson JF, Carraway CAC, Fregien NL, Carraway KL: Sialomucin complex; A heterodimeric glycoprotein complex. J Biol Chem 1996;271:33476-33485.
20. Schroten H, Hanisch FG, Plogmann R, Hacker J, Uhlenbruck G, Nobis-Bosch R, Wahn V: Inhibition of adhesion of S-fimbriated Escherichia coli in buccal epithelial cells by human milk fat globule membrane components: A novel aspect of the protective function of mucins in the nonimmunoglobulin fraction. Infect Immun 1992;60:2893-2899.
21. Schroten H, Lethen A, Hanisch FG, Plogmann R, Hacker J, Nobis-Bosch R, Wahn V: Inhibition of adhesion of S-fimbriated Escherichia coli to epithelial cells by meconium and feces of breast-fed and - fed newborns: Mucins are the major inhibitory component. J Pediatr Gastroenterol Nutr 1992;15:150-158.
22. Schroten H, Plogmann R, Hanisch FG, Hacker J, Nobis-Bosch R, Wahn V: Inhibition of adhesion of S-fimbriated E coli to buccal epitheliall cells by human skim milk is predominantly mediated by mucins and depends on the period of lactation. Acta Paediatr 1993;82:6-11.
23. Patton S, Muller LD: Genetic polymorphism of the epithelial mucin PAS-I in milk samples from the major dairy breeds. J Dairy Sci 1992; 75:863-867.
24. Larocca D, Peterson JA, Bistrain A, Urrea R, Kuniyoshi J, Ceriani RL: A 46 kDa human milk fat globule glycoprotein that is highly expressed in carcinoma cells has homology with human clotting factors V and VIII. Cancer Res 1991;51:4994-4998.
25. Ruoslahti E, Pierschbacher MD: New perspectives in cell adhesion: RGD and integrins. Science 1987; 238:491-497.
26. Couto JR, Godwin S, Taylor MR, Ceriani RL, Peterson JA: Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an EGF-like domain. DNA Cell Biol 1996;15: 281-286.
27. Ortel TL, Devore-Carter D, Quinn-Allen M, Kane WH: Deletion analysis of recombainant human factor V. Evidence for a phosphatidylserine binding site in the second C-type domain. J Biol Chem 1992;267:4189-4198.
28. Newburg DS, Peterson JA, Ruiz-Palacios GM, Matson DO, Morrow AL, Wiederschain GY, Chaturvedi P, Newburg SO, Scallan C, Taylor MR, Kiwan R, Ceriani RL, Pickering LK: Human milk lactadherin: Nature of its carbohydrate linkage and protection against symptomatic rotavirus infection (abstract). Pediatr Res 1996;39:399.
29. Hvarregaard J, Andersen MH, Berglund L, Rasmussen JT, Petersen TE: Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. Eur J Biochem 1996;240:628-636.
30. Stubbs JD, Lekutis C, Singer KL, Bui A, Yuzuki D, Srinivasan U, Parry G: cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc Natl Acad Sci USA 1990;87: 8417-8421.
31. Ogura K, Nara K, Watanabe Y, Kohno K, Tai T, Sanai Y: Cloning and expression of cDNA for O-actylation of GD3 ganglioside. Biochem Biophys Res Commun 1996;225: 932-938.
32. Taylor MR, Couto JR, Scallan C, Ceriani RL, Peterson JA: Lactadherin, a membrane-associated glycoprotein expressed in human milk and breast carcinoma cells, promotes RGD-dependent cell adhesion through integnns. DNA Cell Biol 1997;16:861-869.
33. Brooks PC, Clark RA, Cheresh DA: Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994;264:569-571.
34. Poole S, Firtel RA, Lamar E: Sequence and expression of the discoidin I gene family in Dictyostelium discoideum. J Mol Biol 1981; 153:273-289.
35. Johnson JD, Edman JC, Rutter WJ: A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proc Natl Acad Sci USA 1993;90: 5677-5681.
36. Takagi S, Hirata T, Agata K, Mochii M, Eguchi G, Fujisawa H: The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors. Neuron 1991;7:295-307.
37. Kawakami A, Kitsukawa T, Takagi S, Fujisawa H: Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. J Neurobiol 1996; 29:1-17.
38. Takagi S, Kasuya Y, Shimizu M, Matsuura T, Tsuboi M, Kawakami A: Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. Dev Biol 1995;170:207-222.
39. Peterson JA, Scallan C, Henderson TR, Mehta NR, Ceriani RL, Hamosh M: Human milk fat globule (HMFG) glycoproteins: Their association with lipid micelles in skim milk and survival in the stomach of milk-fed preterm infant (abstract). Pediatr Res 1997;41:87.
40. Mather IH, Banghart LR, Lane WS: The major fat-globule membrane proteins, bovine components 15/16 and guinea-pig GP 55, are homologous to MGF-E8, a murine glycoprotein containing epidermal growth factor-like and factor V/ VIII-like sequences. Biochem Mol Biol Int 1993;29:545-554.
41. Kim DH, Kanno C, Mizokami Y: Purification and characterization of major glycoproteins, PAS-6 and PAS-7, from bovine milk fat globule membrane. Biochim Biophys Acta 1992;1122:203-211.
42. Saenko EL, Scandella D: A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor. J Biol Chem 1995; 270:13826-13833.
43. Gilbert GE, Baleja JD: Membrane-bindirig peptide from the C2 domain of factor VIII forms an amphipathic structure as revealed by NMR spectroscopy. Biochemistry 1995;34:3022-3031
44. Martin SJ, Finucane DM, Amarante-Mendes GP, O'Brien GA, Green DR: Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. J Biol Chem 1996;271:28753-28756
45. Thiagarajan P, Tait JF: Binding of annexin V/placental anticoagulant protein I to platelets: Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J Biol Chem 1990;265: 7420-7423.
46. Yolken RH, Peterson JA, Vonderfecht SL, Fouts ET, Newburg DS: Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. J Clin Invest 1992;90:1984-1991.
47. Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11-25.
48. Lehmann M, Rabenandrasana C, Tamura R, Lissitzky JC, Quaranta V, Pichon J, Marvaldi J: A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6. Cancer Res 1996;54:2102-2107.
49. Jack LJ, Mather IH: Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation. J Biol Chem 1990;265: 14481-14486.
50. Taylor MR, Peterson JA, Ceriani RL, Couto JR: Cloning and sequence analysis of human butyrophilin reveals a potential receptor function. Biochim Biophys Acta 1996;1306:1-4.
51. Peterson JA, Hamosh M, Scallan CD, Ceriani RL, Henderson TR, Mehta NR, Armand M, Hamosh P: Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed premature infants. Pediatric Res, in press.
52. Hamosh M, Peterson JA, Henderson TR, Mehta NR, Scallan C, Kiwan R, Taylor MR, Ceriani RL, Hamosh P: The milk fat globule of human milk: Relationships between glycoproteins and lipids (abstract). FASEB 1997;11:238.
53. Newburg DS, Neubauer SH: Carbohydrate in milks: Analysis, quantities and significance; in Jensen RG (ed): Handbook of Milk Composition. San Diego, Academic Press, 1995, pp 273-349.
54. Newburg DS: Oligosaccharides and glycoconjugates in human milk. Their role in host defence. J Mamm Gland Biol Neoplasia 1996;1:271-283.
55. Viverge D, Grimmonprez I, Cassanas G, Bardet L, Solere M: Variations in oligosaccharides and lactose in human milk during the first week of lactation. Gastroenterol Nutr 1990;11:361-364.
56. Coppa GV, Gabrielli O, Pierani P, Catassi C, Carlucci A, Giorgi PL; Changes in carbohydrate composition of human milk over 4 months' lactation. Pediatrics 1993;91:637-641.
57. Montreuil J, Mullet S: Etude des variations des constituents glucidiques du lait de femme au cours de la lactation. Bull Soc Chim Biol 1960; 42:365-377.
58. Andersson B, Porras O, Hanson LA, Lagergard T, Svanborg-Eden C: Inhibition of attachment of Streptococcus pneumoniae and Haemophilus influenzae by human milk and receptor oligosaccharides. J Infect Dis 1986;153:232-237.
59. Cravioto A, Tello A, Villafan H, Ruiz J, del Vedovo S, Neeser JR: Inhibition of localized adhesion of enteropathogenic Escherichia coli to Hep-2 cells by immunoglobulin and oligosaccharide fractions of human colostrum and breast milk. J Infect Dis 1991;1991:1247-1255.
60. Cervantes LE, Newburg DS, Ruiz-Palacios GM: Fucosylated chains (H-2 and Lewis-b) are the main human milk receptor analogs for Campylobacter (abstract). Pediatr Res 1995;37:171.
61. Crane JK, Azar SS, Stam A, Newburg DS: Oligosaccharides from human milk block, binding and activity of the Escherichia coli heat-stable enterotoxin (STa) in T84 intestinal cells. J Nutr 1994, 1994:2358-2364.
62. Newburg DS, Pickering LD, McCluer RH, Cleary TG: Fucosylated oligosaccharides of human milk protect suckling mice from heat-stable enterotoxin of Escherichia coli. J Infect Dis 1990;162: 1075-1080.
63. Shimizu M, Uryu N, Yamauchi K: Presence of heparan sulfate in the fat globule membrane of bovine and human milk. Agric Biol Chem 1981; 45:741-745.
64. Newburg DS, Viscidi RP, Ruff A, Yolken RH: A human milk factor inhibits binding of human immunodeficiency virus to the CD4 receptor. Pediatr Res 1992; 31:22-28.
65. Newburg DS, Linhardt RJ, Ampofo SA, Yolken RH: Human milk glycosaminoglycans inhibit HIV glycoprotein (gp120) binding to its host cell receptor, CD4. J Nutr 1995;125: 419-424.