Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers

Journal of Clinical Pathology - Molecular Pathology

Volumn 54, Issue 4, 2001, Pages 259-263

  Vaziri, S A J ^a   Tubbs, R R ^a   Darlington, G ^b   Casey, G ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

BRCA1; CCND1; HER2

Indexed keywords

CYCLIN D1; PARAFFIN;

ADULT; BREAST TUMOR; CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; FAMILY HISTORY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE MUTATION; HUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; CYCLIN D1; FEMALE; GENE AMPLIFICATION; GENES, BRCA1; GENES, ERBB-2; HETEROZYGOTE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MUTATION;

EID: 0034908991     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.54.4.259     Document Type: Conference Paper

References (39)

1. Breast cancer incidence, penetrance and survival in probable carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12-21
2. Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage
3. Germ line mutation at BRCA1 affects the histoprognostic grade in hereditary breast cancer
4. Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women
5. Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases
6. Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations
7. The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: A population-based study
8. BRCA-associated breast cancer in young women
9. Pathology and heredity of breast cancer in younger women
10. Early-onset breast cancer - Histopathological and prognostic considerations
11. Distinct molecular pathogeneses of early-onset breast cancers in BRCA1 and BRCA2 mutation carriers: A population-based study
12. Breast tumor pathology and immunophenotype are associated with age of onset of cancer in BRCA1 mutation carriers
13. Expression and amplification of cyclin genes in human breast cancer
14. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
15. Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer
16. Amplification of human int-2 in breast cancers and squamous carcinomas
17. Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations
18. BRCA-associated breast cancer: Absence of a characteristic immunophenotype
19. Clinicopathologic analysis of BRCA1- or BRCA2-associated hereditary breast carcinoma in Japanese women
20. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
21. Gene diagnostics provide new insights into breast cancer prognosis and therapy
22. c-erbB-2 DNA amplification and mRNA expression in human primary breast tumors and its relationship to other prognostic factors
23. HER-2/neu gene amplification compared with HER-2/neu protein overexpression and interobserver reproducibility in invasive breast carcinoma
24. Concomitant oncoprotein detection with fluorescence in situ hybridization (CODFISH). A fluorescence-based assay enabling simultaneous visualization of gene amplification and encoded protein expression
25. Germline BRCA1 alterations in a population-based series of ovarian cancer cases
26. Frequency of BRCA1 and BRCA2 mutations in a clinic-based series of breast and ovarian cancer families
27. Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: Apparent immunohistochemical false-positives do not get the message
28. Predicted anti-oestrogen resistance in BRCA-associated familial breast cancers
29. Chromosome 11q13 abnormalities in human breast cancer
30. Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle
31. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
32. Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
33. Estrogen regulation of cell cycle progression in breast cancer cells
34. Genetic alterations in ERBB2-amplified breast carcinomas
35. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
36. Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization
37. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations
38. MYB oncogene amplification in hereditary BRCA1 breast cancer