Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition

Radiation Research

Volumn 145, Issue 1, 1996, Pages 3-16

  Scott, D ^a   Spreadborough, A R ^a   Jones, L A ^a   Roberts, S A ^a   Moore, C J ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ARTICLE; ATAXIA TELANGIECTASIA; BASAL CELL NEVUS SYNDROME; CANCER SUSCEPTIBILITY; CELL CYCLE G2 PHASE; CHROMOSOME ANALYSIS; DOWN SYNDROME; FAMILIAL CANCER; FANCONI RENOTUBULAR SYNDROME; FIBROBLAST; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; PRIORITY JOURNAL; RADIOSENSITIVITY; XERODERMA PIGMENTOSUM; ADOLESCENT; CASE REPORT; CHROMOSOME ABERRATION; COLON POLYPOSIS; COMPARATIVE STUDY; CYTOLOGY; DISEASE PREDISPOSITION; EYE TUMOR; FANCONI ANEMIA; FEMALE; GENETIC DISORDER; GENETICS; HUMAN CHROMOSOME; INFANT; KINETICS; MIDDLE AGED; MONOZYGOTIC TWINS; NEOPLASM; RADIATION DOSE; RADIATION EXPOSURE; REFERENCE VALUE; RHABDOMYOSARCOMA; TIME; X RAY;

ATAXIA; ATAXIA TELANGIECTASIA;

ADENOMATOUS POLYPOSIS COLI; ADOLESCENT; ATAXIA TELANGIECTASIA; BASAL CELL NEVUS SYNDROME; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; DISEASE SUSCEPTIBILITY; DOWN SYNDROME; EYE NEOPLASMS; FANCONI ANEMIA; FEMALE; G2 PHASE; GENETIC DISEASES, INBORN; HUMANS; INFANT; KINETICS; LI-FRAUMENI SYNDROME; LYMPHOCYTES; MALE; MIDDLE AGED; NEOPLASMS; RADIATION TOLERANCE; REFERENCE VALUES; RHABDOMYOSARCOMA; TIME FACTORS; TWINS, MONOZYGOTIC; X-RAYS; XERODERMA PIGMENTOSUM;

EID: 0029664346     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579189     Document Type: Article

References (35)

1. J. German, Ed., Chromosome Mutation and Neoplasia. Alan R. Liss, New York. 1993.
2. M. Higurashi and P. E. Conen, In vitro chromosomal radiosensitivity in chromosomal breakage syndromes. Cancer 32, 380-383 (1973).
3. A. M. R. Taylor, The effect of radiation on the chromosomes of patients with an unusual cancer susceptibility. In Radiation-Induced Chromosome Damage in Man (T. Ishihara and M. S. Sasaki, Eds.), pp. 167-199. Alan R. Liss, New York. 1993.
4. 2 cell-cycle period of skin fibroblasts from individuals with familial cancer. Proc. Natl Acad. Sci. USA 82, 5400-5403 (1985).
5. Y. Shiloh, R. Parshad, K. K. Sanford and G. M. Jones, Carrier detection in ataxia-telangiectasia. Lancei i, 689-690 (1986).
6. 2 phase X-irradiation, a marker of the ataxia-telangiectasia gene. J Natl. Cancer Inst. 82, 1050-1054 (1990).
7. 2 phase X-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair Proc. Natl. Acad. Sci. USA 80, 5612-5616 (1983).
8. K K. Sanford, R. Parshad, F. M. Price, R. E. Tarone and M. B. Schapiro, X-ray induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness. Cancer Genet. Cytogenet. 70, 25-30 (1993).
9. 2 chromatid radiation damage in familiai dysplastic naevus syndrome. Lancet ii. 1111-1116 (1987).
10. 2 chromatin radiosensitivity in predisposition to cancer. Int. J. Radiat. Biol. 55, 963-981 (1989).
11. R. Parshad. F. M. Price, K. F. Pirollo, E. H. Chang and K. K. Sanford, Cytogenetic response to G2-phase X-irradiation in relation to DNA repair and radiosensitivity in a cancer-prone family with Li-Fraumeni syndrome. Radiat. Res 136, 236-240 (1993).
12. R. Parshad, K. K. Sanford, K. H. Kraemer, G. M. Jones and R. E. Tarone, Carrier detection in xeroderma pigmentosum. J. Clin. Invest. 85, 135-138 (1990).
13. F. M. Price, R. Parshad, R. E. Tarone and K. K. Sanford, Radiation-induced chromatid aberrations in Cockayne syndrome and xeroderma pigmentosum group C fibroblasts in relation to cancer predisposition. Cancer Genet. Cytogenet. 57, 1-10 (1991).
14. 2 chromosomal radiosensitivity in Fanconi's anemia. Mutai. Res. 63, 189-199 (1979).
15. G. Duckworth-Rysiecki and A. M. R. Taylor, Effects of ionizing radiation on cells from Fanconi's anemia patients. Cancer Res. 45, 416-420 (1985).
16. A. T. Natarajan, J. M. J. J. Vossen and M. H. Van Weel-Sipman, Aplastic anemia and Fanconi anemia: Response of lymphocytes to X-rays and mitomycin C. In Fanconi Anaemia (T. M. Schroeder-Kurth and A. D. Auerbach. Eds.), pp. 100-104. Springer-Verlag, Berlin, 1989.
17. 2 on Bloom's syndrome and normal chromosomes. Hum. Genet. 54, 335-341 (1980).
18. R. Tice, J. M. Rary and M. A. Bender, An investigation of DNA repair potential in Bloom's syndrome. J. Supramol. Struct. 2 (SuppL), 82 (1978).
19. 2 chromosomal radiosensitivity in ataxia telangiectasia lymphocytes. Mutai. Res. 152, 39-47 (1985).
20. 2 chromosomal radiosensitivity and cell survival in the cancer family syndrome. Cancer Res. 48, 2579-2584 (1988).
21. A. T. Natarajan, M. Meijers and J. L. S. Van Rijn, Individual variability of human cells in induction of chromosomal alterations by mutagens. In Mutagens in Our Environment (M. Sorsa and H. Vainio, Eds.), pp. 75-88. Alan R. Liss, New York, 1982.
22. A. M. R. Taylor, Cytogenetics of ataxia telangiectasia. In Ataxia-Telangiectasia: A Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency (B. A. Bridges and D. G. Harnden, Eds.), pp. 53-81. Wiley, Chichester, 1982.
23. F. M. Price and K. K. Sanford, Cleaning and preparation of glassware for cell culture. Tiss. Culture Assoc. Manual 1, 59-60 (1975).
24. 2. Int. J. Radiat. Biol. 54, 843 (1988). [Abstract]
25. 2 chromatid aberrations in X-irradiated human lymphocytes. Mutagenesis 7, 285-290 (1992).
26. G. J. Neary, H. J. Evans and S. M. Tonkinson, A quantitative determination of the mitotic delay induced by gamma radiation in broad bean root meristems. J. Genet. 56, 363-394 (1959).
27. S. H. Revell, The accurate estimation of chromatid breakage and its relevance to a new interpretation of chromatid aberrations induced by ionising radiations. Proc. Roy. Soc. B 150, 563-589 (1959).
28. W. C. Dewey, Chromatid and half chromatid aberrations in Chinese hamster cells X-irradiated in metaphase, prophase or G2. In The Cell Cycle in Malignancy and Immunity (J. C. Hampton, Ed.), pp. 182-192. National Technical Information Service, Springfield, VA, 1975.
29. D. Scott, L. A. Jones, S. A. G. Elyan, A. Spreadborough, R. Cowan and G. Ribiero, Identification of AT heterozygotes. In Ataxia-Telangiectasia (R. A. Gatti and R. B. Painter, Eds.), pp. 101-116. NATO ASI Series H: Cell Biology, Vol. 77, Springer-Verlag, Berlin, 1993.
30. J. M. Birch, A, L. Hartley, K. J. Tricker, J. Presser, A. Cundie, A. M. Kelsey, M. Harris, P. H. Morris Jones, A. Binchy, D. Crowther, A. W. Craft, O. B. Eden, G. R. Evans, E. Thompson, J. R. Mann, J. Martin, E. L. D. Mitchell and M. F. Santibanez-Koref, Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res. 54, 1298-1304 (1994).
31. J. M. Birch, J. Heighway, M. D. Teare, A. M. Kelsey, A. L. Hartley, D. Crowther, D. P. Lane and M. F. Santibanez-Koref, Linkage studies in a Li-Fraumeni family with increased expression of p53 protein, but no germline mutations in p53. Br. J. Cancer 70, 1176-1181 (1994).
32. S. J. Armstrong, A. W. Duncan and M. G. Mott, Rhabdomyosarcoma associated with familial adenomatous polyposis. Pediat Radial. 21, 445-446 (1991).
33. T. Featherstone, A. M. R. Taylor and D. G. Harnden, Studies on the radiosensitivity of cells from patients with basal cell naevus syndrome. Am. J. Hum. Genet. 35, 58-65 (1983).
34. J. R. Weincke, D. W. Wara, J. B. Little and K. T. Kelsey, Heterogeneity in the clastogenic response to X-rays in lymphocytes from ataxia-telangiectasia heterozygotes and controls. Cancer Causes Control 3, 237-245 (1992).
35. D. Scott, A. Spreadborough, E. Levine and S. A. Roberts, Genetic predisposition in breast cancer. Lancer 344, 1444 (1994).