Acute and late toxicity, tumour control and intrinsic radiosensitivity of primary fibroblasts in vitro of patients with advanced head and neck cancer after concomitant boost radiochemotherapy

Radiotherapy and Oncology

Volumn 53, Issue 3, 1999, Pages 233-245

  Rudat, Volker ^a   Dietz, Andreas ^a   Nollert, Jörg ^a   Conradt, Christian ^a   Weber, Klaus Josef ^a   Flentje, Michael ^b   Wannenmacher, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Fibroblast radiosensitivity; Head and neck; Larynx oedema; Normal tissues; Predictive assay; Radiotherapy

Indexed keywords

CARBOPLATIN;

ACUTE TOXICITY; ADULT; AGED; ARTICLE; BONE NECROSIS; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FIBROBLAST; HEAD CANCER; HUMAN; HUMAN TISSUE; LARYNX EDEMA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NECK CANCER; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; SKIN FIBROSIS;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; FEMALE; FIBROBLASTS; FOLLOW-UP STUDIES; FORECASTING; HEAD AND NECK NEOPLASMS; HUMANS; LARYNGEAL EDEMA; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RADIATION INJURIES; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; SKIN; TREATMENT OUTCOME;

EID: 0032804103     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(99)00149-8     Document Type: Article

References (22)

1. Begg A.C., Russell N.S., Knaken H., Lebesque J.V. Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. Int. J. Radiat. Biol. 64:1993;393-405.
2. Bentzen S.M., Overgaard M. Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother. Oncol. 20:1991;159-165.
3. Bentzen S.M., Overgaard M., Overgaard J. Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur. J. Cancer. 29A:1993;1373-1376.
4. Bernier J., Thames H.D., Smith C.D., Horiot J.C. Tumour response, mucosal reactions and late effects after conventional and hyperfractionated radiotherapy. Radiother. Oncol. 47:1998;137-143.
5. Brock W.A., Tucker S.L., Geara F.B., et al. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int. J. Radiat. Oncol. Biol. Phys. 32:1995;1371-1379.
6. Burnet N.G., Nyman J., Turesson I., Wurm R., Yarnold J.R., Peacock J.H. Prediction of normal-tissue tolerance to radiotherapy from in vitro cellular radiation sensitivity. Lancet. 339:1992;1570-1571.
7. Burnet N.G., Nyman J., Turesson I., Wurm R., Yarnold J.R., Peacock J.H. The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiother. Oncol. 33:1994;228-238.
8. Deschavanne P.J., Debieu D., Fertil B., Malaise E.P. Re-evaluation of in vitro radiosensitivity of human fibroblasts of different genetic origins. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 50:1986;279-293.
9. Geara F.B., Peters L.J., Ang K.K., et al. Comparison between normal tissue reactions and local tumour control in head and neck cancer patients treated by definitive radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 35:1996;455-462.
10. Geara F.B., Peters L.J., Ang K.K., Wike J.L., Brock W.A. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys. 27:1993;1173-1179.
11. Holthusen H. Erfahrungen über die verträglichkeitsgrenze für röntgenstrahlen und deren nutzanwendung zur verhütung von schäden. Strahlentherapie und Onkologie. 57:1936;254-269.
12. Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Evidence for a positive correlation between in vitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy. Int. J. Radiat. Biol. 66:1994;407-412.
13. Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother. Oncol. 40:1996;101-109.
14. Kaanders J.H., van Daal W.A., Hoogenraad W.J., van der Kogel A.J. Accelerated fractionation radiotherapy for laryngeal cancer, acute, and late toxicity. Int. J. Radiat. Oncol. Biol. Phys. 24:1992;497-503.
15. Peters L.J. The ESTRO Regaud lecture. Inherent radiosensitivity of tumour and normal tissue cells as a predictor of human tumour response. Radiother. Oncol. 17:1990;177-190.
16. Rodemann H.P., Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother. Oncol. 35:1995;83-90.
17. Rudat V., Dietz A., Conradt C., Weber K.J., Flentje M. In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiother. Oncol. 43:1997;181-188.
18. Russell N.S., Grummels A., Hart A.A., et al. Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer. Int. J. Radiat. Biol. 73:1998;661-670.
19. Sandner A., Lippolt C., Fehrentz D., Oetzel D. Ziviplan, Ein programm zur schnellen bestrahlungsplanung rechteckiger und irregulärer stehfelder. Medizinische Physik. 1992;144-145.
20. Staar S., Rudat V., Volling P., Mueller R.-P., Flentje M., Schroeder M. Results of a german multicenter trial of accelerated hyperfractionated radiochemotherapy in advanced head and neck cancer. Radiother. Oncol. 40:(Suppl 1):1996;14.
21. Tucker S.L., Turesson I., Thames H.D. Evidence for individual differences in the radiosensitivity of human skin. Eur. J. Cancer. 28A:1992;1783-1791.
22. West C.M., Davidson S.E., Elyan S.A., et al. The intrinsic radiosensitivity of normal and tumour cells. Int. J. Radiat. Biol. 73:1998;409-413.