Dendritic cells and immunity to leishmaniasis and toxoplasmosis

Current Opinion in Immunology

Volumn 14, Issue 4, 2002, Pages 466-470

  Scott, Phillip ^a   Hunter, Christopher A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 12; PERTUSSIS TOXIN; CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR;

ANIMAL CELL; CELL MIGRATION; CELL STIMULATION; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEISHMANIASIS; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TOXOPLASMOSIS; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; HELPER CELL; IMMUNITY; IMMUNOLOGY; METABOLISM; MOUSE;

ANIMALS; DENDRITIC CELLS; DROSOPHILA PROTEINS; HUMANS; IMMUNITY; INTERLEUKIN-12; LEISHMANIASIS; MEMBRANE GLYCOPROTEINS; MICE; MODELS, IMMUNOLOGICAL; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES, HELPER-INDUCER; TOLL-LIKE RECEPTORS; TOXOPLASMOSIS;

EID: 0036668243     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00353-9     Document Type: Review

References (53)

1. The control of T cell responses by dendritic cell subsets
2. Dendritic cells and the control of immunity
3. Dendritic cells
4. Dendritic cells as sensors of infection
5. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice
6. Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells
7. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: Selective impairment of IL-12 induction in Leishmania-infected cells
8. Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis
9. Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-κB
10. Suppression of NF-κB activation by infection with Toxoplasma gondii
11. Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous leishmaniasis
12. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity
13. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
14. Murine dendritic cells internalize Leishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferation in vitro
15. IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40/CD40 ligand-dependent process
16. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
17. Pretreatment with recombinant Flt3 ligand partially protects against progressive cutaneous leishmaniasis in susceptible BALB/c mice
18. Human polymorphonuclear leukocytes produce IL-12, TNF-α, and the chemokines macrophage-inflammatory protein-1 α and -1 β in response to Toxoplasma gondii antigens
19. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection
20. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
21. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii
22. Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: Dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-γ
23. + dendritic cells
24. Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses
25. Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes
26. 4+ T cells in vivo
27. Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii
28. Vaccination against the intracellular pathogens Leishmania major and L. amazonensis by directing CD40 ligand to macrophages
29. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
30. Th2 response induction by dendritic cells: A role for CD40
31. The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis
32. Disruption of CD40-CD40 ligand interactions results in enhanced susceptibility to Leishmania amazonensis infection
33. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
34. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
35. The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation
36. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4
37. IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice
38. Increased interleukin 4 (IL-4) receptor expression and IL-4-induced decrease in IL-12 production by Langerhans cells infected with Leishmania major
39. The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment
40. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology
41. Lipoxin-mediated inhibition of IL-12 production by DCs: A mechanism for regulation of microbial immunity
42. Innate immunity: The virtues of a nonclonal system of recognition
43. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
44. Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide
45. Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein
46. A Leishmania protein that modulates interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production and expression of B7-1 in human monocyte-derived antigen-presenting cells
47. Toll-like receptors control activation of adaptive immune responses
48. Identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli
49. An innate sense of danger
50. Dendritic cell subsets and the regulation of Th1/Th2 responses
51. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo
52. - dendritic cells to prime Th1/Th2 cells in vivo
53. IL-12 induction by a TH1-inducing adjuvant in vivo dendritic cell subsets and regulation by IL-10