Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes

European Journal of Immunology

Volumn 31, Issue 3, 2001, Pages 876-883

  Bennett, Clare L ^a   Misslitz, Ana ^b   Colledge, Lisa ^a   Aebischer, Toni ^b   Clare Blackburn, C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Activation signal; Dendritic cell; Green fluorescent protein; Leishmania

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 12;

AMASTIGOTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL ACTIVATION; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE MODEL; FEMALE; HELPER CELL; IMMUNE RESPONSE; IN VITRO STUDY; INCUBATION TIME; LEISHMANIA MEXICANA; LEISHMANIASIS; MOUSE; NONHUMAN; PARASITE; PRIORITY JOURNAL; PROMASTIGOTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; BONE MARROW CELLS; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; IMMUNOPHENOTYPING; INTERLEUKIN-12; LEISHMANIA MEXICANA; MICE; MICE, INBRED C57BL; MICE, INBRED CBA;

EID: 0035076991     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200103)31:3<876::AID-IMMU876>3.0.CO;2-I     Document Type: Article

References (48)

1. The interaction of Leishmania species with macrophages
2. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
3. Altered immune responses in mice lacking inducible nitric oxide synthase
4. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice
5. Antigen presentation by macrophages harboring intravesicular pathogens
6. Phagocytosis of Leishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production
7. Immunology of leishmaniasis
8. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells
9. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
10. Dendritic cells and the control of immunity
11. Innate immunity: The virtues of a nonclonal system of recognition
12. Innate immune recognition: Mechanisms and pathways
13. Tolerance, danger and the extended family
14. Murine dendritic cells internalize Leishmania major promastigotes, produced IL-12 p40 and stimulate primary T cell proliferation in vitro
15. The control of T cell responses by dendritic cell subsets
16. Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania
17. Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes
18. Deficient expression of co-stimulatory molecules on Leishmania-infected macrophages
19. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
20. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: Selective impairment of IL-12 induction in Leishmania-infected cells
21. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
22. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
23. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
24. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
25. The mannose receptor is a pattern recognition receptor involved in host defense
26. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif
27. The role of CpG motifs in innate immunity
28. Fc gamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization
29. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cethepsin S-dependent pathway of MHC class II presentation
30. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
31. Glycoconjugates in Leishmania infectivity
32. Molecular basis of interactions between parasites and the complement cascade
33. Role of macrophage complement and lectin-like receptors in binding Leishmania parasites to host macrophages
34. Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum
35. Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins
36. Uptake of Leishmania major amastigotes results in activation and interleukin-12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity
37. A Leishmania protein that modulates interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production and expression of B7-1 in human monocyte-derived antigen-presenting cells
38. Surface antigens of Leishmania mexicana amastigotes: Characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid
39. The C-type lectin superfamily in the immune system
40. The role of macrophage receptors in adhesion and uptake of Leishmania mexicana amastigotes
41. Lipophosphoglycan blocks attachment of Leishmania major amastigotes to macrophages
42. Comparison of receptors required for entry of Leishmania major amastigotes into macrophages
43. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis
44. Phlebotomus papatasi and fly salivary gland lysate down-regulates a Th1, but up-regulates a Th2, response in mice infected with Leishmania major
45. Phlebotomus papatasi saliva inhibits protein phosphatase activity and nitric oxide production by murine macrophages
46. Development of a natural model of cutaneous leishmaniasis: Powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis
47. 2-microglobulin-deficient mice
48. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor