A receptor presentation hypothesis for T cell help that recruits autoreactive B cells

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1562-1571

  Zhang, X ^a   Smith, D S ^a   Guth, A ^a   Wysocki, L J ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CHROMATIN; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCUS; HYBRIDOMA; INTRON; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; STEM CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 0035253592     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1562     Document Type: Article

References (73)

1. Systemic lupus erythematosus
2. Antinuclear antibodies: Diagnostic markers and clues to the basis of systemic autoimmunity
3. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
4. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
5. H gene usage
6. +/+ mouse: Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA
7. 1 mouse
8. An early post-mutational selection event directs expansion of autoreactive B cells in murine lupus
9. Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice
10. The lupus autoantigens and the pathogenesis of systemic lupus erythematosus
11. Genetic and structural evidence for antigen selection of anti-DNA antibodies
12. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single stranded DNA transgenic MRL/lpr mice
13. B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice
14. T-cell-receptor β- and I-A β-chain genes of normal SWR mice are linked with the development of lupus nephritis in NZB × SWR crosses
15. 1 mice
16. + T cells is required to suppress autoimmunity
17. Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black × New Zealand white mice: Response correlates with the absence of an anti-antibody response
18. The effect of thymectomy on lupus-prone mice
19. 1 mice with established nephritis: Preservation of kidney function
20. T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted
21. Murine lupus in the absence of α β T cells
22. α β T cell regulation and CD40 ligand dependence in murine systemic autoimmunity
23. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus
24. Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain
25. Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus
26. T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus
27. Reciprocal T-B determinant spreading develops spontaneously in murine lupus: Implications for pathogenesis
28. Epitope spreading: The role of self peptides and autoantigen processing by B lymphocytes
29. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
30. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
31. Two better cell lines for making hybridomas expressing specific T cell receptors
32. T cell recognition and tolerance of antibody diversity
33. A rapid colorimetric assay for the determination of IL-2-producing helper T cell frequencies
34. Idiotypes of anti-la antibodies. I. Expression of the 14-4-4S idiotype in humoral immune responses
35. Antigen presentation by supported planar membranes containing affinity-purified I-Ad
36. Substitution of class II α chain polymorphic residues defines location of A α k serologic epitopes and alters association between α β and Ii polypeptides
37. Surprisingly uneven distribution of the T cell receptor V β repertoire in wild mice
38. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes
39. The structure of V α and J α segments in the mouse
40. Mouse T-cell receptor variable gene segment families
41. Concerning the specificity of histone and non-histone dissociation from calf thymus chromatin by salt
42. Monoclonal anti-histone autoantibodies derived from murine models of lupus
43. H and V κ genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate
44. The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse
45. Gene conversion of immunoglobulin variable regions in mutagenesis cassettes by replacement PCR mutagenesis
46. Verification of a model of a F(ab) complex with phenylarsonate by oligonucleotide-directed mutagenesis
47. B-cell proliferation initiated by la cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro
48. Molecular events during maturation of the immune response to oxazolone
49. Somatic evolution of variable region structures during an immune response
50. Tracing the development of single memory-lineage B cells in a highly defined immune response
51. Evolution of antibody structure during the immune response: The differentiative potential of a single B lymphocyte
52. Immunoglobulin-specific T-B cell interaction. I, Presentation of self immunoglobulin determinants by B lymphocytes
53. B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells
54. T cell recognition of somatically-generated Ab diversity
55. A kinetic basis for T cell receptor repertoire selection during an immune response
56. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
57. Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition
58. Requirement of H-2-subregion differences for graft-versus-host autoimmunity in mice: Superiority of the differences at class-II H-2 antigens (I-A/I-E)
59. Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease
60. Susceptibility to lupus nephritis in the NZB/W model system
61. Genetic susceptibility to systemic lupus erythematosus
62. Relationships among antinuclear antibodies from autoimmune MRL mice reacting with histone H2A-H2B dimers and DNA
63. Genetic dissection of SLE pathogenesis: Slel on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes
64. Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions
65. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
66. Receptor editing: An approach by autoreactive B cells to escape tolerance
67. Receptor editing in selfreactive bone marrow B cells
68. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse
69. Residues that mediate DNA binding of autoimmune antibodies
70. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation
71. MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells
72. Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes
73. Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes