Quantitative structure-activity relationships for inducers of cytochromes P450 and nuclear receptor ligands involved in P450 regulation within the CYP1, CYP2, CYP3 and CYP4 families

Toxicology

Volumn 176, Issue 1-2, 2002, Pages 51-57

  Lewis, D F V ^a   Jacobs, M N ^a   Dickins, M ^b   Lake, B G ^c  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c TNO BIBRA International Ltd   (United Kingdom)

Author keywords

Cytochromes; Homology modelling studies; Nuclear receptor ligands; Quantitative structure activity relationships

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1; CYTOCHROME P450 2; CYTOCHROME P450 3; CYTOCHROME P450 4; ESTROGEN RECEPTOR; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; CONTROLLED STUDY; CORRELATION FUNCTION; CRYSTAL STRUCTURE; HUMAN; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 0036643983     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00135-X     Document Type: Article

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