Similarities and differences in the coupling of human β1- and β2-adrenoceptors to Gsα splice variants

Biochemical Pharmacology

Volumn 64, Issue 1, 2002, Pages 9-20

  Wenzel Seifert, Katharina ^a   Liu, Hui Yu ^a   Seifert, Roland ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

1 Adrenoceptor; Adenylyl cyclase; Constitutive activity; Fusion protein; Gs splice variants

Indexed keywords

ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; ISOPRENALINE; PARTIAL AGONIST;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN VARIANT; RNA SPLICING; STOICHIOMETRY;

ADENYLATE CYCLASE; ANIMALS; CELL MEMBRANE; CELLS, CULTURED; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; INSECTS; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TRANSFECTION;

EID: 0036639891     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00924-3     Document Type: Article

References (42)

1. G proteins: Transducers of receptor-generated signals
2. Receptor-effector coupling by G proteins
3. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
4. Functional and structural complexity of signal transduction via G-protein-coupled receptors
5. Adrenergic receptors as models for G protein-coupled receptors
6. 1-adrenergic receptor
7. 2-adrenergic receptors in Chinese hamster fibroblasts
8. 2-adrenergic receptors stably expressed in transfected hamster cells
9. 2-adrenergic receptors
10. 2-adrenergic receptors
11. Expression of two human β-adrenergic receptors in Escherichia coli: Functional interaction with two forms of the stimulatory G protein
12. s
13. 2-adrenergic receptor coupling and sequestration
14. 1-adrenergic receptor
15. 2 double knockout mice
16. 1-receptor transgenic mice
17. 2-adrenergic receptors
18. sα in Escherichia coli. Purification and properties of two forms of the protein
19. sα has properties of a constitutively active receptor
20. sα splice variants
21. Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins
22. q-proteins
23. sα fusion protein
24. α fusion proteins: An approach for the molecular analysis of receptor/G-protein coupling
25. Insights into ligand pharmacology using receptor-G-protein fusion proteins
26. 3
27. sαshort: Consequences for receptor-coupling and adenylyl cyclase activation
28. sα fusion protein
29. 1-adrenergic receptor
30. G-protein-coupled receptors: What limits high-affinity agonist binding?
31. G-protein-coupled receptors: What limits high-affinity agonist binding? Reply
32. A quantitative analysis of β-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modeling of ligand binding data
33. i/oα fusion proteins
34. Functional differences between full and partial agonists: Evidence for ligand-specific receptor conformations
35. s interactions: Evidence for multiple receptor conformations
36. Differential coupling of glucagon and β-adrenergic receptors with the small and large forms of the stimulatory G protein
37. Increased expression of adenylylcyclase type VI proportionately increases β-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes
38. sα GTPase activity
39. Pharmacological and biochemical characterization of complexes of muscarinic acetylcholine receptor and guanine nucleotide-binding protein
40. Does subunit dissociation necessarily accompany the activation of all heterotrimeric G proteins?
41. Rethinking receptor-G protein-effector interactions
42. s