The olfactory G protein Gαolf possesses a lower GDP-affinity and deactivates more rapidly than Gsαshort: Consequences for receptor-coupling and adenylyl cyclase activation

Journal of Neurochemistry

Volumn 78, Issue 2, 2001, Pages 325-338

  Liu, Hui Yu ^a   Wenzel Seifert, Katharina ^a   Seifert, Roland ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Adenylyl cyclase; Fusion protein; G olf, Gs short, GDP affinity, G protein deactivation, receptor G

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HYBRID PROTEIN; PROTEIN G ALPHA OLF; PROTEIN GS ALPHA SHORT SPLICE VARIANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ALTERNATIVE SPLICING; ANIMALS; CELL LINE; CELL MEMBRANE; DIHYDROALPRENOLOL; DOBUTAMINE; EPHEDRINE; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; ISOPROTERENOL; KINETICS; RATS; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SPODOPTERA; TRANSFECTION; VARIATION (GENETICS);

ANIMALIA; INSECTA;

EID: 0034922158     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00422.x     Document Type: Article

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