Mechanisms of spindle positioning: Focus on flies and worms

Trends in Cell Biology

Volumn 12, Issue 7, 2002, Pages 332-339

  Gönczy, Pierre ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE; CAENORHABDITIS ELEGANS; CELL DIVISION; CELL FATE; CELL POLARITY; CHROMOSOME SEGREGATION; CYTOPLASM; DEPOLYMERIZATION; DROSOPHILA; EMBRYO DEVELOPMENT; FLY; HUMAN; METAZOON; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; REVIEW; SPINDLE POLE BODY; WORM; ANIMAL; CYTOLOGY; METABOLISM; NEMATODE; PHYSIOLOGY; ULTRASTRUCTURE;

ARACHNIDA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; HEXAPODA; METAZOA;

MOLECULAR MOTOR;

ANIMALS; CELL POLARITY; CHROMOSOME SEGREGATION; DIPTERA; MICROTUBULES; MITOTIC SPINDLE APPARATUS; MOLECULAR MOTOR PROTEINS; NEMATODA;

EID: 0036631382     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(02)02306-1     Document Type: Review

References (65)

1. Cytokinesis in animal cells
2. Assembly and positioning of microtubule asters in microfabricated chambers
3. Astral microtubule dynamics in yeast: A microtubule-based searching mechanism for spindle orientation and nuclear migration into the bud
4. Micromanipulation studies of the asymmetric positioning of the maturation spindle in Chaetopterus sp. oocytes. I. Anchorage of the spindle to the cortex and migration of a displaced spindle
5. Astral and spindle forces in PtK2 cells during anaphase B: A laser microbeam study
6. Cancer. A CINtillating new job for the APC tumor suppressor
7. It's a kar9ochore to capture microtubules
8. Mitosis: A history of division
9. Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization
10. Cytoplasmic dynein is localized to kinetochores during mitosis
11. Localization of cytoplasmic dynein to mitotic spindles and kinetochores
12. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos
13. Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells
14. The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics
15. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex
16. Search, capture and signal: Games microtubules and centrosomes play
17. Control of spindle polarity and orientation in Saccharomyces cerevisiae
18. Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast
19. Positioning of the mitotic spindle by a cortical-microtubule capture mechanism
20. Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules
21. Molecular linkage underlying microtubule orientation toward cortical sites in yeast
22. Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast
23. Yeast Num1p associates with the mother cell cortex during S/G2 phase and affects microtubular functions
24. The cortical protein Num1p is essential for dynein-dependent interactions of microtubules with the cortex
25. Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process
26. Specification of the anteroposterior axis in Caenorhabditis elegans
27. Fertilization and establishment of polarity in the embryo
28. Axis determination in C. elegans: Initiating and transducing polarity
29. Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo
30. Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos
31. i/o binding motif and potential guanine-nucleotide exchange factor
32. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
33. Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos
34. Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans
35. G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics
36. A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila
37. Analysis of Partner of Inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in Inscuteable apical localization
38. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
39. Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
40. Centrosome movement in the early divisions of Caenorhabditis elegans: A cortical site determining centrosome position
41. Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo
42. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos
43. Transient localized accumulation of actin in Caenorhabditis elegans blastomeres with oriented asymmetric divisions
44. The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
45. Neurogenesis in the insect central nervous system
46. Asymmetric cell division: Fly neuroblast meets worm zygote
47. Protein localization during asymmetric cell division
48. Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system
49. Lineage diversity in the Drosophila nervous system
50. Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
51. Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
52. Adherens junctions inhibit asymmetric division in the Drosophila epithelium
53. APC binds to the novel protein EB1
54. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules
55. Spindles cotton on to junctions, APC and EB1
56. Role of Inscuteable in orienting asymmetric cell divisions in Drosophila
57. Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
58. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
59. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
60. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation
61. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos
62. The role of centrosomes and astral microtubules during asymmetric division of Drosophila neuroblasts
63. Asymmetric segregation of Numb and Prospero during cell division
64. The role of the yeast spindle pole body and the mammalian centrosome in regulating late mitotic events
65. Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion