Roles of TUP1 in switching, phase maintenance, and phase-specific gene expression in Candida albicans

Eukaryotic Cell

Volumn 1, Issue 3, 2002, Pages 353-365

  Zhao, Rui ^a   Lockhart, Shawn R ^a   Daniels, Karla ^a   Soll, David R ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDA; CANDIDA ALBICANS; FUNGI; MYXOGASTRIA; SACCHAROMYCETALES;

FUNGAL DNA; FUNGAL PROTEIN; FUNGAL RNA; MESSENGER RNA; TRANSCRIPTION FACTOR;

ARTICLE; BIOLOGICAL MODEL; CANDIDA ALBICANS; FUNGAL GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHENOTYPE;

BASE SEQUENCE; CANDIDA ALBICANS; DNA, FUNGAL; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; MODELS, GENETIC; MUTATION; PHENOTYPE; RNA, FUNGAL; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0036615318     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.1.3.353-365.2002     Document Type: Article

References (66)

1. Anderson, J. M., and D. R. Soll. 1987. Unique phenotype of opaque cells in the "white-opaque transition" of Candida albicans. J. Bacteriol. 169:5579-5588.
2. Anderson, J., R. Mihalik, and D. R. Soll. 1990. Ultrastructure and antigenicity of the unique cell wall pimple of the Candida opaque phenotype. J. Bacteriol. 172:224-235.
3. Bedell, G. W., and D. R. Soll. 1979. Effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: evidence for zinc-resistant and -sensitive pathways for mycelium formation. Infect. Immun. 26:348-354.
4. Birse, C. E., M. Y. Irwin, W. A. Fonzi, and P. S. Sypherd. 1993. Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans. Infect. Immun. 61:3648-3655.
5. Bone, J. R., and S. Y. Roth. 2001. Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone deacetylation. J. Biol. Chem. 276:1808-1813.
6. Braun, B. R., and A. D. Johnson. 1997. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277:105-109.
7. Braun, B. R., and A. D. Johnson. 2000. TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 155:57-67.
8. Braun, B. R., W. S. Head, M. X. Wang, and A. D. Johnson. 2000. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 156:31-44.
9. Braun, B. R., D. Kadosh, and A. D. Johnson. 2001. NRG1, a repressor of filamentous growth in C. albicans, is downregulated during filament induction. EMBO J. 20:4753-4761.
10. Brown, A. J., and N. A. Gow. 1999. Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol. 7:333-338.
11. Care, R. S., J. Trevethick, K. M. Binley, and P. E. Sudbery. 1999. The MET3 promoter: a new tool for Candida albicans molecular genetics. Mol. Microbiol. 34:792-798.
12. Cooper, J. P., S. Y. Roth, and R. T. Simpson. 1994. The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev. 8:1400-1410.
13. DeRisi, J. L., V. R. Iyer, and P. O. Brown. 1997. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680-686.
14. Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
15. Herschbach, B. M., M. B. Arnaud, and A. D. Johnson. 1994. Transcriptional repression directed by the yeast alpha 2 protein in vitro. Nature 370:309-311.
16. Hube, B., M. Monod, D. Schofield, A. Brown, and N. Gow. 1994. Expression of seven members of the gene family encoding aspartyl proteinases in Candida albicans. Mol. Microbiol. 14:87-99.
17. Hull, C. M., and A. D. Johnson. 1999. Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285:1271-1275.
18. Imai, S., C. M. Armstrong, M. Kaeberlein, and L. Guarente. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800.
19. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992. Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68:708-719.
20. Khalaf, R. A., and R. S. Zitomer. 2001. The DNA binding protein Rfg1 is a repressor of filamentation in Candida albicans. Genetics 157:1503-1512.
21. Klar, A., T. Srikantha, and D. R. Soll. 2001. A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. Genetics 158:919-924.
22. Komachi, K., M. J. Redd, and A. D. Johnson. 1994. The WD repeats of Tup1 interact with the homeo domain protein alpha 2. Genes Dev. 8:2857-2867.
23. Kvaal, C. A., T. Srikantha, and D. R. Soll. 1997. Misexpression of the white phase-specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence. Infect. Immun. 65:4468-4475.
24. Lachke, S. A., T. Srikantha, L. K. Tsai, K. Daniels, and D. R. Soll. 2000. Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-11 and the newly discovered hemolysin gene HLP. Infect. Immun. 68:884-895.
25. Lo, H.-J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutations are a virulent. Cell 90:939-949.
26. Lockhart, S. R., M. Nguyen, T. Srikantha, and D. R. Soll. 1998. A MADS box protein consensus binding site is necessary and sufficient for activation of the opaque-phase specific gene OP4 of Candida albicans. J. Bacteriol. 180:6607-6616.
27. Magee, P. T., and K. Chibana. 2001. The genomes of Candida albicans and other Candida species, p. 293-304. In R. Calderone (ed.), Candida and candidiasis. American Society of Microbiology, Washington, D.C.
28. Merson-Davles, L. A., and F. C. Odds. 1989. A morphology index for characterization of cell shape in Candida albicans. J. Gen. Microbiol. 135:3143-3152.
29. Mitchell, A. 1998. Dimorphism and virulence in Candida albicans. Curr. Opin. Microbiol. 1:687-692.
30. Morrow, B., J. Anderson, E. Wilson, and D. R. Soll. 1989. Bidirectional stimulation of the white-opaque transition of Candida albicans by ultraviolet irradiation. J. Gen. Microbiol. 135:1201-1208.
31. Morraw, B., T. Srikantha, J. Anderson, and D. R. Soll. 1993. Coordinate regulation of two opaque-phase-specific genes during white-opaque switching in Candida albicans. Infect. Immun. 61:1823-1828.
32. Morrow, B., T. Srikantha, and D. R. Soll. 1992. Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans. Mol. Cell. Biol. 12:2997-3005.
33. Morrow, B., H. Ramsey, and D. R. Soll. 1994. Regulation of phase-specific genes in the more general switching system of Candida albicans strain 3153A. J. Med. Vet. Mycol. 32:287-394.
34. Murad, A., A. Munir, P. Leng, M. Straffon, J. Wishart, S. Macaskill, D. MacCullum, N. Schnell, D. Talibi, D. Marechal, F. Tekaia, C. d'Enfert, C. Gaillardin, F. C. Odds, and A. J. P. Brown. 2001. NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO. J. 20:4742-4752.
35. Odds, F. C. 1997. Switch of phenotype as an escape mechanism of the intruder. Mycoses 40:S9-S12.
36. Perez-Martin, J., J. A. Uria, and A. D. Johnson. 1999. Phenotypic switching in Candida albicans is controlled by a SIR2 gene. EMBO J. 18:2580-2592.
37. Pomes, R., C. Gil, and C. Nombela. 1985. Genetic analysis of Candida albicans morphological mutants. J. Gen. Microbiol. 131:2107-2113.
38. Ramsey, H., B. Morrow, and D. R. Soll. 1994. An increase in switching frequency correlates with an increase in recombination of the ribosomal chromosomes of Candida albicans strain 3153A. Microbiology 140:1525-1531.
39. Rikkerink, E. H. A., B. B. Magee, and P. T. Magee. 1988. Opaque-white phenotype transition: a programmed morphological transition in Candida albicans. J. Bacteriol. 170:895-899.
40. Scherer, S., and D. A. Stevens. 1987. Application of DNA typing methods to epidemiology and taxonomy of Candida species. J. Clin. Microbiol. 25:675-679.
41. Schiestl, R. H., and R. D. Gietz. 1989. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Curr. Genet. 16:339-346.
42. Sharkey, L. I., M. D. McNemar, S. M. Saporito-Irwin, P. S. Sypherd, and W. A. Fonzi. 1999. HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J. Bacteriol. 181:5273-5279.
43. Slutsky, B., J. Buffo, and D. R. Soll. 1985. High-frequency switching of colony morphology in Candida albicans. Science 42:666-669.
44. Slutsky, B., M. Staebell, J. Anderson, L. Risen, M. Pfaller, and D. R. Soll. 1987. "White-opaque transition": a second high-frequency switching system in Candida albicans. J. Bacteriol. 169:189-197.
45. Soll, D. R. 1992. High-frequency switching in Candida albicans. Clin. Microbiol. Rev. 5:183-203.
46. Soll, D. R. 1992. Switching and its possible role in Candida pathogenesis, p. 156-172. In J. E. Bennett, R. J. Hay, and P. K. Peterson (ed.), New strategies in fungal disease. Churchill Livingstone, Edinburgh, United Kingdom.
47. Soll, D. R. 1997. Gene regulation during high-frequency switching in Candida albicans. Microbiology 143:279-288.
48. Soll, D. R. 2001. The molecular biology of switching in Candida, p. 161-182. In R. Cihlar and R. Calderone (ed.), Fungal pathogenesis: principles and clinical application. Marcel Dekker, New York, N.Y.
49. Soll, D. R. 2001. Phenotypic switching, p. 123-142. In R. Calderone (ed.), Candida and candidiasis. American Society for Microbiology, Washington, D.C.
50. Soll, D. R., J. Anderson, and M. Bergen. 1991. The developmental biology of the white-opaque transition in Candida albicans, p. 20-45. In R. Prasad (ed.), Candida albicans: cellular and molecular biology. Springer-Verlag, New York, N.Y.
51. Srikantha, T., A. Chandrasekhar, and D. R. Soll. 1995. Functional analysis of the promoter of the phase-specific WH11 gene of Candida albicans. Mol. Cell. Biol. 15:1797-1805.
52. Srikantha, T., and D. R. Soll. 1993. A white-specific gene in the white-opaque switching system of Candida albicans. Gene 131:53-60.
53. Srikantha, T., L. K. Tsai, and D. R. Soll. 1997. The WH11 gene of Candida albicans is regulated in two distinct developmental programs through the same transcription activation sequences. J. Bacteriol. 179:3837-3844.
54. Srikantha, T., L. Tsai, K. Daniels, and D. R. Soll. 2000. EFG1 null mutant of Candida albicans can switch, but cannot suppress the complete phenotype of white budding cells. J. Bacteriol. 182:1580-1591.
55. Srikantha, T., L. Tsai, K. Daniels, L. Enger, K. Highley, and D. R. Soll. 1998. The two-component hybrid kinase regulator CaN1K1 of Candida albicans. Microbiology 144:2715-2729.
56. Srikantha, T., L. Tsai, K. Daniels, A. Klar, and D. R. Soll. 2001. The deacetylases HDA1 and RPD3 play complex roles both in switching and phase-specific gene regulation in Candida albicans. J. Bacteriol. 183:4614-4625.
57. Staab, J. F., C. A. Ferrer, and P. Sundstrom. 1996. Developmental expression of a tandemly repeated, proline- and glutamine-rich amino acid motif on hyphal surfaces of Candida albicans. J. Biol. Chem. 271:6298-6305.
58. Staab, J. F., S. D. Bradway, P. I. Fidel, and P. Sundstrom. 1999. Adhesive and mammalian transglutaminase substrate properties of Candida albicans HWP1. Science 283:1535-1538.
59. Stoldt, V. R., A. Sonneborn, C. E. Leuker, and J. F. Ernst. 1997. Efg1p, and essential regulator of morphogenics of the human pathogen Candida albicans is a member of a conserved class of bHCH proteins regulating morphogenetic processes in fungi. EMBO J. 16:1982-1991.
60. Treitel, M. A., and M. Carlson. 1995. Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc. Natl. Acad. Sci. USA 92:3132-3136.
61. Tzamarias, D., and K. Struhl. 1994. Functional dissection of the yeast Cyc8-Tup1 transcriptional corepressor complex. Nature 369:758-761.
62. Tzung, K.-W., R. M. Williams, S. Scherer, N. Federspiel, T. Jones, C. Komp, R. Surzycki., R. Tamse, R. W. Davis, and N. Agabian. 2001. Genomic evidence for a complete sexual cycle in Candida albicans. Proc. Natl. Acad. Sci. USA 98:3249-3253.
63. Watson, A. D., D. G. Edmondson, J. R. Bone, Y. Mukai, Y. Yu, W. Du, D. J. Stillman, and S. Y. Roth. 2000. Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 14:2737-2744.
64. Whalen, W. L., and D. R. Soll. 1982. Mitotic recombination in Candida albicans: recessive lethal alleles linked to a gene required for methionine biosynthesis. Mol. Gen. Genet. 187:477-485.
65. White, T. C., S. H. Miyasaki, and N. Agabian. 1993. Three distinct secreted aspartyl proteinases in Candida albicans. J. Bacteriol. 175:6126-6135.
66. Wu, J., N. Suka, M. Carlson, and M. Grunstein, 2001. TUP1 utilizes histone H3/H2B-specific H DA1 deacetylase to repress gene activity in yeast. Mol. Cell 7:117-126.