Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery

Biochemical Pharmacology

Volumn 63, Issue 9, 2002, Pages 1763-1772

  Pauvert, O ^a   Salvail, D ^b   Rousseau, E ^b   Lugnier, C ^c   Marthan, R ^a   Savineau, J P ^a  

^a INSERM   (France)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c CNRS   (France)

Author keywords

Cyclic nucleotide; Phosphodiesterase; Smooth muscle; Subcellular fractions; Vascular tone

Indexed keywords

9 (2 HYDROXY 3 NONYL)ADENINE; CALCIUM; CILOSTAMIDE; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ENZYME INHIBITOR; ISOENZYME; PHOSPHODIESTERASE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; ROLIPRAM; UNCLASSIFIED DRUG; ZAPRINAST;

ANIMAL TISSUE; ANION EXCHANGE CHROMATOGRAPHY; ARTERY MEDIA; ARTICLE; BLOOD VESSEL TONE; CATTLE; CELL FRACTIONATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG POTENCY; DRUG SENSITIVITY; ENDOTHELIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; HYDROLYSIS; ISOENZYME ANALYSIS; ISOLATION PROCEDURE; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CATTLE; CHROMATOGRAPHY, ION EXCHANGE; CYCLIC AMP; CYCLIC GMP; CYTOSOL; ISOENZYMES; NUCLEOTIDES, CYCLIC; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PULMONARY ARTERY; TUNICA MEDIA; VASOCONSTRICTION;

EID: 0036569896     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00919-X     Document Type: Article

References (45)

1. Characterisation of cyclic nucleotide phosphodiesterase isoforms in the bovine pulmonary artery
2. Regulation of pulmonary vascular tone
3. Complexity of mammalian adenylyl cyclases
4. Guanylyl cyclases and signaling by cGMP
5. Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery
6. Identification of PDE isoenzymes in human pulmonary artery and effect of selective PDE inhibitors
7. Potentiation of cyclic AMP-mediated vasorelaxation by phenylephrine in pulmonary arteries of the rat
8. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase
9. NO-induced modulation of calcium-oscillations in pulmonary vascular smooth muscle
10. Cyclic nucleotide phosphodiesterases and vascular smooth muscle
11. Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation
12. Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
13. Cyclic nucleotide phosphodiesterases: Relating structure function
14. Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases
15. Characterisation of membrane bound cyclic nucleotides phosphodiesterases from bovine aortic smooth muscle
16. Modulation of vascular cyclic nucleotide phosphodiesterases by cGMP: Role in vasodilatation
17. Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: Changes in pulmonary hypertension
18. Phosphodiesterase activity in intrapulmonary arteries and venous lambs
19. Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity
20. Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonaries arteries
21. E-4010 a selective phosphodiesterase 5 inhibitor attenuates hypoxic pulmonary hypertension in rats
22. Effect of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension
23. Effect of DMPPO a phosphodiesterase type 5 inhibitor on hypoxic pulmonary hypertension in rats
24. Large conducting potassium channel reconstituted from airway smooth muscle
25. Protein measurement with the folin phenol reagent
26. Chracterisation of indolian- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions
27. Isoenzyme-selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine
28. Specific cyclic nucleotide phosphodiesterase inhibitors differently modulate contractile kinetics in airway smooth muscle
29. Isolation and characterisation of PDE9A: A novel human cGMP-specific phosphodiesterase
30. Cloning and characterisation of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)
31. Molecular cloning and characterisation of a distinct human phosphodiesterase gene family: PDE11A
32. Calcium movements, distribution and functions in smooth muscle
33. 2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase
34. Modulation of the calcium sensitivity of the smooth muscle contractile apparatus: Molecular mechanisms, pharmacological and pathophysiological implications
35. Hypoxic vasoconstriction of rat main pulmonary artery: Role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition
36. Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle
37. Isolation of cyclic nucleotide phosphodiesterase isosymes from pig aorta
38. 3 cells
39. Cross-talk between NO and cyclic nucleotide phosphodiesterase in the modulation of signal transduction in blood vessel
40. Characterisation of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei
41. The relaxant and spasmogenic effects of some xanthine derivatives acting on guinea-pig isolated trachealis muscle
42. Caffeine acting on pregnant rat myometrium: Analysis of its relaxant action and its failure to release Ca from intracellular stores
43. Existence of functional ryanodine- and cafeine-sensitive Ca-release channels in human isolated bronchial smooth muscle
44. 2+ pump blockers: Thapsigargin and cyclopiazonic acid
45. Relaxation of arterial smooth muscle by calcium sparks