Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI

Biochemical and Biophysical Research Communications

Volumn 277, Issue 1, 2000, Pages 27-36

  Ezumi, Yasuharu ^a   Uchiyama, Takashi ^a   Takayama, Hiroshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Collagen receptor; Glycoprotein VI; Human platelets; Isoforms

Indexed keywords

COLLAGEN; COMPLEMENTARY DNA; FC RECEPTOR; GLYCOPROTEIN; GLYCOPROTEIN VI; IMMUNOGLOBULIN; ISOPROTEIN; PHORBOL ESTER; RECEPTOR; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 19Q; CONTROLLED STUDY; DNA LIBRARY; EXON; FLOW CYTOMETRY; GENE STRUCTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEGAKARYOCYTE; MOLECULAR CLONING; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; START CODON; TATA BOX; THROMBOCYTE; THROMBOCYTE ACTIVATION;

EID: 0034649228     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3624     Document Type: Article

References (30)

1. Platelet-collagen interactions: Membrane receptors and intracellular signalling pathways
2. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia
3. Cyclic AMP-insensitive activation of c-Src and Syk protein-tyrosine kinases through platelet membrane glycoprotein VI
4. Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI
5. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattle-snake) venom via the p62/GPVI collagen receptor
6. 1
7. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: Collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity
8. 1
9. Glycoprotein VI is a major collagen receptor for platelet activation: It recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not
10. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets
11. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor γ chain complex on human platelets
12. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
13. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor γ-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
14. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets
15. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcαR and the natural killer receptors
16. Characterization of the family of dimers associated with Fc receptors (FcεRI and FcγRIII)
17. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia
18. Growth and differentiation of a human megakaryoblastic cell line, CMK
19. Isolation and characterization of platelet glycoprotein IV (CD36)
20. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
21. Platelet glycoprotein VI: Cloning, structure, and expression of a functional protein
22. A comprehensive genetic map of the human genome based on 5,264 microsatellites
23. A physical map of 30,000 human genes
24. Tissue-specific expression of the platelet GPIIb gene
25. The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression
26. Characterization of the gene encoding human platelet glycoprotein IX
27. Gene cloning of rat and mouse platelet glycoprotein V: Identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage
28. Fc receptor biology