Unrestrained caspase-dependent cell death caused by loss of Diap 1 function requires the Drosophila Apaf-1 homolog, Dark

EMBO Journal

Volumn 21, Issue 9, 2002, Pages 2189-2197

  Rodriguez, Antony ^a   Chen, Po ^a   Oliver, Holt ^a   Abrams, John M ^b  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apaf 1; Apoptosis; Drosophila; IAP; PCD

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN DARK; PROTEIN DIAP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; DROSOPHILA; ENZYME ACTIVATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASES; CENTRAL NERVOUS SYSTEM; DROSOPHILA; DROSOPHILA PROTEINS; EPISTASIS, GENETIC; INHIBITOR OF APOPTOSIS PROTEINS; INSECT PROTEINS; NEUROPEPTIDES; PEPTIDES; PROTEINS;

INTRACISTERNAL A-PARTICLES; MAMMALIA;

EID: 0036566395     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.9.2189     Document Type: Article

References (54)

1. An emerging blueprint for apoptosis in Drosophila
2. Programmed cell death during Drosophila embryogenesis
3. Drosophila p53 binds a damage response element at the reaper locus
4. Apaf1 (Ced-4 homolog) regulates programmed cell death in mammalian development
5. Drosophila apoptosis and Bcl-2 genes: Outliers fly in
6. Grim, a novel cell death gene in Drosophila
7. IAP family proteins-suppressors of apoptosis
8. Origin and differentiation of supernumerary midline glia in Drosophila embryos deficient for apoptosis
9. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
10. Cell death inhibition: Keeping caspases in check
11. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
12. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
13. BCL-2 family members and the mitochondria in apoptosis
14. Characterization of XIAP-deficient mice
15. Understanding IAP function and regulation: A view from Drosophila
16. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
17. Apoptosis-ced-4 is a stranger no more
18. The biochemistry of apoptosis
19. The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury
20. Programmed cell death in animal development
21. The Drosophila inhibitor of apoptosis D-IAP1 suppresses cell death induced by the caspase drICE
22. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
23. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila
24. Facing death in the fly: Genetic analysis of apoptosis in Drosophila
25. Dying like flies
26. Apoptosis in development
27. The Drosophila caspase DRONC is regulated by DIAP1
28. Genetics of programmed cell death in C. elegans-past, present and future
29. An exegesis of IAPs: Salvation and surprises from BIR motifs
30. Caspases-killer proteases
31. Guardian ancestry: Fly p53 and damage-inducible apoptosis
32. Activation of the reaper gene during ectopic cell killing in Drosophila
33. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
34. Imaging neuronal subsets and other cell types in wholemount Drosophila embryos and larvae
35. Molecular prophets of death in the fly
36. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
37. Caspases-intracellular signaling by proteolysis
38. Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim
39. Apoptosis in the pathogenesis and treatment of disease
40. Cell death in development
41. Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs)
42. Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins Hid and Grim
43. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
44. Genetic control of programmed cell death in Drosophila
45. Cell killing by the Drosophila gene reaper
46. Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes
47. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
48. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
49. The C.elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1B-converting enzyme
50. Programmed cell death in the Drosophila central nervous system midline
51. Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells
52. HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis
53. An APAF-1/cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9