Regulation of the mitochondrial permeability transition pore by ubiquinone analogs. A progress report

Free Radical Research

Volumn 36, Issue 4, 2002, Pages 405-412

  Walter, Ludivine ^a   Miyoshi, Hideto ^b   Leverve, Xavier ^a   Bernardi, Paolo ^c   Fontaine, Eric ^a  

^a UNIV GRENOBLE ALPES   (France)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

Cell death; Mitochondria; Permeability transition; Quinones

Indexed keywords

CALCIUM ION; UBIQUINONE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL DEATH; CHEMICAL STRUCTURE; CONTROLLED STUDY; MEMBRANE CHANNEL; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MODEL; POROSITY;

EID: 0036554572     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760290021252     Document Type: Article

References (29)

1. Mitchell, P. (1979) "Keilin's respiratory chain concept and its chemiosmotic consequences", Science 206, 1148-1159.
2. Bernardi, P. (1999) "Mitochondrial transport of cations: channels, exchangers and permeability transition", Physiol. Rev. 79, 1127-1155.
3. Bernardi, P, Scorrano, L., Colonna, R., Petronilli, V. and Di Lisa, F. (1999) "Mitochondria and cell death. Mechanistic aspects and methodological issues", Eur. J. Biochem. 264, 687-701.
4. Liu, X., Kim, C.N., Yang, J., Jemmerson, R. and Wang, X. (1996) "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c", Cell 86, 147-157.
5. Du, C., Fang, M., Li, Y., Li, L. and Wang, X. (2000) "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition", Cell 102, 33-42.
6. Ekert, P.G., Silke, J., Connolly, L.M., Reid, G.E., Moritz, R.L and Vaux, D.L. (2000) "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins", Cell 102, 43-53.
7. Bernardi, P., Petronilli, V., Di Lisa, F. and Forte, M. (2001) "A mitochondrial perspective on cell death", Trends Biochem. Sci 26, 112-117.
8. Nicolli, A., Basso, E., Petronilli, V., Wenger, R.M. and Bernardi, P. (1996) "Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel", J. Biol. Chem. 271, 2185-2192.
9. Yoshimoto, T. and Siesjo, B.K. (1999) "Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia", Brain Res. 839, 283-291.
10. Li, P.A., Uchino, H., Elmer, E. and Siesjo, B.K. (1997) "Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia", Brain Res. 753, 133-140.
11. Friberg, H., Ferrand-Drake, M., Bengtsson, F., Halestrap, A.P. and Wieloch, T. (1998) "Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death", J. Neurosci. 18, 5151-5159.
12. Ferrand-Drake, M., Friberg, H. and Wieloch, T. (1999) "Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia", Neuroscience 90, 1325-1338.
13. Okonkwo, D.O., Buki, A., Siman, R. and Povlishock, J.T. (1999) "Cyclosporin A, limits calcium-induced axonal damage following traumatic brain injury", Neuroreport 10 353-358.
14. Okonkwo, D.O. and Povlishock, J.T. (1999) "An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury", J. Cer. Blood Flow Metab. 19, 443-451.
15. Di Lisa, F., Menabò, R., Canton, M., Barile, M. and Bernardi, P. (2001) "Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart", J. Biol. Chem. 276, 2571-2575.
16. Clipstone, N.A. and Crabtree, G.R. (1992) "Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation", Nature 357, 695-697.
17. Khaspekov, L., Friberg, H., Halestrap, A., Viktorov, I. and Wieloch, T. (1999) "Cyclosporin A, and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons", Eur. J. Neurosci. 11, 3194-3198.
18. Fontaine, E., Eriksson, O., Ichas, F. and Bernardi, P. (1998) "Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex I", J. Biol. Chem. 273, 12662-12668.
19. Fontaine, E., Ichas, F. and Bernardi, P. (1998) "A ubiquinone-binding site regulates the mitochondrial permeability transition pore", J. Biol. Chem. 273, 25734-25740.
20. Martinucci, S., Szabo, I., Tombola, F. and Zoratti, M. (2000) "Ca2+-reversible inhibition of the mitochondrial megachannel by ubiquinone analogues", FEBS Lett. 480, 89-94.
21. Walter, L., Nogueira, V., Leverve, X., Bernardi, P. and Fontaine, E. (2000) "Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site", J. Biol. Chem. 275, 29521-29527.
22. Fontaine, E. and Bernardi, P. (1999) "Progress on the mitochondrial permeability transition pore. Regulation by Complex I and ubiquinone analogs", J. Bioenerg. Biomembr. 31, 335-345.
23. Fato, R., Estornell, E., Di, B.S., Pallotti, F., Castelli, G.P. and Lenaz, G. (1996) "Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles", Biochemistry 35, 2705-2716.
24. Bresolin, N., Doriguzzi, C., Ponzetto, C., Angelini, C., Moroni, I., Castelli, E., Cossutta, E., Binda, A., Gallanti, A., Gabellini, S., et al., (1990) "Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial", J. Neurol. Sci. 100, 70-78.
25. Favit, A., Nicoletti, F., Scapagnini, U. and Canonico, P.L. (1992) "Ubiquinone protects cultured neurons against spontaneous and excitotoxin-induced degeneration", J. Cerebral Blood Flow Metab. 12, 638-645.
26. Edlund, C., Holmberg, K., Dallner, G., Norrby, E. and Kristensson, K. (1994) "Ubiquinone-10 protects neurons from virus-induced degeneration", J. Neurochem. 63, 634-639.
27. Takeo, S., Tanonaka, K., Tazuma, Y, Miyake, K. and Murai, R. (1987) "Possible mechanism by which coenzyme Q10 improves reoxygenation-induced recovery of cardiac contractile force after hypoxia", J. Pharmacol. Exp. Ther. 243, 1131-1138.
28. Crestanello, J.A., Kamelgard, J., Lingle, D.M., Mortensen, S.A., Rhode, M. and Whitman, G.J. (1996) "Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment" J. Thoracic Cardiovasc. Surg. 111, 443-450.
29. Matthews, R.T., Yang, L., Browne, S., Baik, M. and Beal, M.F. (1998) "Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects", Proc. Natl Acad. Sci. USA 95, 8892-8897.