메뉴 건너뛰기




Volumn 25, Issue 3, 2002, Pages 121-123

'...and C is for Clioquinol' - The AβCs of Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; BIOLOGICAL MARKER; CLIOQUINOL; COPPER ION; FERRIC ION; METALLOPROTEIN; AMYLOID BETA PROTEIN; CHELATING AGENT; DIAGNOSTIC AGENT;

EID: 0036498343     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)02086-5     Document Type: Review
Times cited : (28)

References (26)
  • 1
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • D. Schenk Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 1999 173 177
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 2
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
    • R.A. Cherny Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice Neuron 30 2001 665 676
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cherny, R.A.1
  • 3
    • 0033801852 scopus 로고    scopus 로고
    • Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
    • H.L. Weiner Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease Ann. Neurol. 48 2000 567 579
    • (2000) Ann. Neurol. , vol.48 , pp. 567-579
    • Weiner, H.L.1
  • 4
    • 0034700471 scopus 로고    scopus 로고
    • Aβ-peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • C. Janus Aβ-peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 408 2000 979 982
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1
  • 5
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • F. Bard Peripherally administered antibodies against amyloid β peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease Nat. Med. 6 2000 916 919
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1
  • 6
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • R.B. DeMattos Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 98 2001 8850 8855
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1
  • 7
    • 0033551782 scopus 로고    scopus 로고
    • Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion
    • R.A. Cherny Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion J. Biol. Chem. 274 1999 23223 23228
    • (1999) J. Biol. Chem. , vol.274 , pp. 23223-23228
    • Cherny, R.A.1
  • 8
    • 0032557425 scopus 로고    scopus 로고
    • Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis
    • C.S. Atwood Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis J. Biol. Chem. 273 1998 12817 12826
    • (1998) J. Biol. Chem. , vol.273 , pp. 12817-12826
    • Atwood, C.S.1
  • 9
    • 0001052504 scopus 로고    scopus 로고
    • Copper catalyzed oxidation of Alzheimer A
    • C.S. Atwood Copper catalyzed oxidation of Alzheimer A Cell. Mol. Biol. 46 2000 777 783
    • (2000) Cell. Mol. Biol. , vol.46 , pp. 777-783
    • Atwood, C.S.1
  • 10
    • 18344414746 scopus 로고    scopus 로고
    • The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
    • X. Huang The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry 38 1999 7609 7616
    • (1999) Biochemistry , vol.38 , pp. 7609-7616
    • Huang, X.1
  • 11
    • 0033601338 scopus 로고    scopus 로고
    • Cu(II) potentiation of Alzheimer Aβ neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
    • X. Huang Cu(II) potentiation of Alzheimer Aβ neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction J. Biol. Chem. 274 1999 37111 37116
    • (1999) J. Biol. Chem. , vol.274 , pp. 37111-37116
    • Huang, X.1
  • 12
    • 0034733705 scopus 로고    scopus 로고
    • Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc
    • M.P. Cuajungco Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc J. Biol. Chem. 275 2000 19439 19442
    • (2000) J. Biol. Chem. , vol.275 , pp. 19439-19442
    • Cuajungco, M.P.1
  • 13
    • 0027980901 scopus 로고
    • Rapid induction of Alzheimer Aβ amyloid formation by zinc
    • A.I. Bush Rapid induction of Alzheimer Aβ amyloid formation by zinc Science 265 1994 1464 1467
    • (1994) Science , vol.265 , pp. 1464-1467
    • Bush, A.I.1
  • 14
    • 0032507975 scopus 로고    scopus 로고
    • Copper, iron and zinc in Alzheimer's disease senile plaques
    • M.A. Lovell Copper, iron and zinc in Alzheimer's disease senile plaques J. Neurol. Sci. 158 1998 47 52
    • (1998) J. Neurol. Sci. , vol.158 , pp. 47-52
    • Lovell, M.A.1
  • 15
    • 0035827681 scopus 로고    scopus 로고
    • Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
    • C.C. Curtain Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits J. Biol. Chem. 276 2001 20466 20473
    • (2001) J. Biol. Chem. , vol.276 , pp. 20466-20473
    • Curtain, C.C.1
  • 16
    • 0035229653 scopus 로고    scopus 로고
    • Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts
    • A.I. Bush L.E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts Novartis Found. Symp. 235 2001 26 38
    • (2001) Novartis Found. Symp. , vol.235 , pp. 26-38
    • Bush, A.I.1    Goldstein, L.E.2
  • 17
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • C.A. McLean Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease Ann. Neurol. 46 1999 860 866
    • (1999) Ann. Neurol. , vol.46 , pp. 860-866
    • McLean, C.A.1
  • 18
    • 0032837741 scopus 로고    scopus 로고
    • The levels of soluble versus insoluble brain Aβ distinguish Alzheimer's disease from normal and pathologic aging
    • J. Wang The levels of soluble versus insoluble brain Aβ distinguish Alzheimer's disease from normal and pathologic aging Exp. Neurol. 158 1999 328 337
    • (1999) Exp. Neurol. , vol.158 , pp. 328-337
    • Wang, J.1
  • 19
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • L.F. Lue Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease Am. J. Pathol. 155 1999 853 862
    • (1999) Am. J. Pathol. , vol.155 , pp. 853-862
    • Lue, L.F.1
  • 20
    • 33750914982 scopus 로고
    • Clioquinol
    • G. Padmanabhan Clioquinol E. Klauss E. Florey Analytical Profiles of Drug Substances 1989 Academic Press 57 90
    • (1989) , pp. 57-90
    • Padmanabhan, G.1
  • 21
    • 85101569542 scopus 로고    scopus 로고
    • Clioquinol's return
    • A.I. Bush C.L. Masters Clioquinol's return Science 292 2001 2251 2252
    • (2001) Science , vol.292 , pp. 2251-2252
    • Bush, A.I.1    Masters, C.L.2
  • 22
    • 0033974529 scopus 로고    scopus 로고
    • Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol
    • M.S. Yassin Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol J. Neurol. Sci. 173 2000 40 44
    • (2000) J. Neurol. Sci. , vol.173 , pp. 40-44
    • Yassin, M.S.1
  • 23
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
    • K. Hsiao Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1
  • 24
    • 0033139740 scopus 로고    scopus 로고
    • Histochemically reactive zinc in plaques of the Swedish mutant β-amyloid precursor protein transgenic mice
    • J.Y. Lee Histochemically reactive zinc in plaques of the Swedish mutant β-amyloid precursor protein transgenic mice J. Neurosci. 19 1999 RC10
    • (1999) J. Neurosci. , vol.19 , pp. RC10
    • Lee, J.Y.1
  • 25
    • 0031944692 scopus 로고    scopus 로고
    • Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo
    • M.A. Pappolla Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo Am. J. Pathol. 152 1998 871 877
    • (1998) Am. J. Pathol. , vol.152 , pp. 871-877
    • Pappolla, M.A.1
  • 26
    • 0035221587 scopus 로고    scopus 로고
    • Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin
    • S.J. Haugabook Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin FASEB J. 15 2001 16 18
    • (2001) FASEB J. , vol.15 , pp. 16-18
    • Haugabook, S.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.