p53 activation, a key event of the cellular response to gamma irradiation;L'activation de la protéine p53, un événement déterminant de la réponse cellulaire aux radiations ionisantes

Medecine Nucleaire

Volumn 26, Issue 3, 2002, Pages 139-147

  Drane P ^a   Alvarez, S ^a   Meiller, A ^a   May, Evelyne ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

Apoptosis; Mdm2; p53; Phosphorylation; Transactivation

Indexed keywords

PROTEASOME; PROTEIN 14 3 3; PROTEIN MDM2; PROTEIN P53; TRANSACTIVATOR PROTEIN; UBIQUITIN;

ACETYLATION; AMINO ACID SEQUENCE; APOPTOSIS; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CARCINOGENIC ACTIVITY; CELL CYCLE; GAMMA IRRADIATION; GENE EXPRESSION; GENOTOXICITY; GROWTH DISORDER; IONIZING RADIATION; ONCOGENE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RADIATION EXPOSURE; REVIEW; STRESS; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

EID: 0036489806     PISSN: 09281258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Twenty years of p53 research: Structural and functional aspects of the p53 protein
2. Structural aspects of p53 protein in relation to gene evolution: A second look
3. MDM2 - Arbiter of p53's destruction
4. Lessons from the p53 mutant mouse
5. p53-depen-dent apoptosis suppresses radiation-induced teratogenesis
6. Spontaneous and ionizing radiation-induced Chromosomal abnormalities in p53-deficient mice
7. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
8. Tissue and cell-specific expression of the p53-target genes: Bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice
9. Mice lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
10. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
11. A transactivation-deficient mouse model provides insights into Trp53 regulation and function
12. Regulation of p53 function
13. Regulation of p53 downstream genes
14. The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
15. Why is p53 acetylated?
16. The p53 pathway and apoptosis
17. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3proteins
18. 14-3-3 Proteins: Key regulators of cell division, signalling and apoptosis
19. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways
20. The DNA damage response: Putting checkpoints in perspective
21. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
22. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
23. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
24. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
25. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
26. Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
27. Regulation of the G2/M transition by p53
28. Surfing the p53 network
29. APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
30. Signaling to p53: Breaking the posttranslational modification code