Adenosine A2 receptor-induced inhibition of leukotriene B4 synthesis in whole blood ex vivo

British Journal of Pharmacology

Volumn 117, Issue 8, 1996, Pages 1639-1644

  Krump, E ^a   Lemay, G ^a   Borgeat, P ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Adenosine; Adenosine A2 receptor; Dipyridamole; Leukotriene B4; Whole blood

Indexed keywords

2 CHLOROADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 6 N CYCLOPENTYLADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE DERIVATIVE; CAFFEINE DERIVATIVE; DIPYRIDAMOLE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEUKOTRIENE B4; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE; ADENOSINE RECEPTOR; ANTITHROMBOCYTIC AGENT; CARDIOVASCULAR AGENT;

ARTICLE; BLOOD; DRUG POTENCY; HUMAN; HUMAN CELL; LEUKOCYTE; MONOCYTE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ADENOSINE; CARDIOVASCULAR AGENTS; DIPYRIDAMOLE; HUMANS; LEUKOTRIENE B4; LIPOPOLYSACCHARIDES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PLATELET AGGREGATION INHIBITORS; RECEPTORS, PURINERGIC P1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029658925     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15334.x     Document Type: Article

References (51)

1. 4 causes proliferation of interleukin-2 dependent T cells in the presence of suboptimal levels of interleukin-2. Cell. Immunol., 99, 444-452.
2. BEUTLER, B., MILSARK, I.W. & CERAMI, A.C. (1985). Passive immunisation against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science (Wash. DC), 229, 869-871.
3. 4. Clin. Biochem., 23, 459-468.
4. BORGEAT, P., PICARD, S., VALLERAND, P., BOURGOIN, S., ODEIMAT, A., SIROIS, P. & POUBELLE, P.E. (1990). Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography. In Methods in Enzymology, ed. Murphy R.C. & Fitzpatrick, F.A., pp. 98-116. New York: Academic Press.
5. BOUMA, M.G., STAD, R.K., VANDENWILDENBERG, F.A.J. & BUURMAN, W.A. (1994). Differential regulatory effects of adenosine on cytokine release by activated human monocytes. J. Immunol., 153, 4159-4168.
6. BOYUM, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1g. Scand. J. Clin. Lab. Invest., 21, 77.
7. CHEN, X.S., SHELLER, J.R., JOHNSON, E.N. & FUNK, C.D. (1994). Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature, 372, 179-182.
8. 4 in the Immune System. Int. J. Immunopharmacol., 14, 441-449.
9. COGGESHALL, J.W., CHRISTMAN, B.W., LEFFERTS, P.L., SERAFIN, W.E., BLAIR, I.A., BUTTERFIELD, M.J. & SNAPPER, J.R. (1988). Effect of inhibition of 5-lipoxygenase metabolism of arachidonic acid on response to endotoxemia in sheep. J. Appl. Physiol., 65, 1351.
10. COLLIS, M.G. & HOURANI, S.M.O. (1993). Adenosine receptor subtypes. Trends Pharmacol. Sci., 14, 360-366.
11. CRONSTEIN, B.N. (1994). Adenosine, an endogenous anti-inflammatory agent. J. Appl. Physiol., 76, 5-13.
12. 2 generation, respectively. J. Clin. Invest., 85, 1150-1157.
13. CRONSTEIN, B.N., HAINES, K.A., KOLASINSKI, S.L. & REIBMAN, J. (1992). Occupancy of Gαs-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil. Blood, 80, 1052-1057.
14. CRONSTEIN, B.N., LEVIN, R.I., BELANOFF, J., WEISSMANN, G & HIRSCHHORN, R. (1986). Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells. J. Clin. Invest., 78, 760-770.
15. CRONSTEIN, B.N., NAIME, D. & OSTAD, E. (1993). The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J. Clin. Invest., 92, 2675-2682.
16. EPPELL, B.A., NEWELL, A.B. & BROWN, E.J. (1989). Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. J. Immunol., 143, 4141-4145.
17. FONTEH, A.N., WINKLER, J.D., TORPHY, T.J., HERAVI, J., UNDEM, B.J. & CHILTON, F.H. (1993). Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in human neutrophils. J. Immunol., 151, 339-350.
18. 4 in inflammation. Crit. Rev. Immunol., 10, 1-12.
19. FORMAN, M.B., VELASCO, C.E. & JACKSON, E.K. (1993). Adenosine attenuates reperfusion injury following regional myocardial ischemia. Cardiovasc. Res., 27, 9-17.
20. 4 in endotoxin-induced lung injury in unanesthetized sheep. Respir. Physiol., 11, 259-268.
21. GREEN, P.G., BASBAUM, A.I., HELMS, C. & LEVINE, J.D. (1991). Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat. Proc. Natl. Acad. Sci. U.S.A., 88, 4162-4165.
22. GRISHAM, M.B., HERNANDEZ, L.A. & GRANGER, D.N. (1989). Adenosine inhibits ischemia-reperfusion-induced leukocyte adherence and extravasation. Am. J. Physiol., 257, H1334-H1339.
23. GUALDE, N., ATLURU, D. & GOODWIN, J.S. (1985). Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets. J. Immunol., 134, 1125-1129.
24. HAWKES, J.S., CLELAND, L.G., PROUDMAN, S.M. & JAMES, M.J. (1994). The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis. J. Rheumatol., 21, 55-58.
25. HORIGUCHI, J., SPRIGGS, D., IMAMURA, K., STONE, R., LUEBBERS, R. & KUFE, D. (1989). Role of arachidonic acid metabolism in transcriptional induction of tumor necrosis factor gene expression by phorbol ester. Mol. Cell. Biol., 54, 269-274.
26. IANNONE, M.A., WOLBERG, G. & ZIMMERMAN, T. (1989). Chemotactic peptide induces cAMP elevation in human neutrophils by amplification of the adenylate cyclase response to endogenously produced adenosine. J. Biol. Chem., 264, 20177-20180.
27. 2-adenosine antagonist in vitro and in vivo. FEBS Lett., 323, 141-144.
28. KAMINSKI, P.M. & PROCTOR, K.G. (1989). Attenuation of no-reflow phenomenon, neutrophil activation, and reperfusion injury in intestinal microcirculation by topical adenosine. Circ. Res., 65, 426-435.
29. LEROUX, J.L., DAMON, M., CHAVIS, C., DEPAULET, A. & BLOTMAN, K. (1992). Single dose of methotrexate on 5-lipoxygenase and 12-lipoxygenase products in patients with rheumatoid arthritis. J. Rheumatol., 19, 863-866.
30. LE VRAUX, V., CHEN, Y.L., MASSON, I., DE SOUSA, M., GIROUD, J.P., FLORENTIN, I. & CHAUVELOT-MOACHON, L. (1993). Inhibition of human monocyte TNF production by adenosine receptor agonists. Life Sci., 52, 1917-1924.
31. MARTICH, G.D., DANNER, R.L., CESKA, M. & SUFFREDINI, A.F. (1991). Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. J. Exp. Med., 173, 1021-1024.
32. MARTS, B.C., BAUDENDISTAL, L.J., NAUNHEIM, K.S. & DAHMS, T.E. (1993). Protective effect of 2-chloro-adenosine on lung ischemia reperfusion injury. J. Surg. Res., 54, 523-529.
33. MATERA, G., COOK, J.A., HENNIGAR, R.A., TEMPEL, G.E., WISE, W.C., OGLESBY, T.D. & HALUSHKA, P.V. (1988). Beneficial effects of a 5-lipoxygenase inhibitor in endotoxic shock in the rat. J. Pharmacol. Exp. Ther., 247, 363-371.
34. MOROZ, C. & STEVENS, R.H. (1980). Suppression of immunoglobulin production in normal human B lymphocytes by two T-cell subsets distinguished following in vitro treatment with adenosine. Clin. Immunol. Immunopathol., 15, 44-51.
35. MÖSER, G.H., SCHRADER, J. & DEUSSEN, A. (1989). Turnover of adenosine in plasma of human and dog blood. Am. J. Physiol., 256, C799-C806
36. PALMANTIER, R., SURETTE, M.E., SANCHEZ, A., BRAQUET, P. & BORGEAT, P. (1994). Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-a. Lab. Invest., 70, 696-704.
37. PARMELY, M.J., ZHOU, W.W., EDWARDS, I.C.K., BORCHERDING, D.R., SILVERSTEIN, R. & MORRISON, D.C. (1993). Adenosine and a related carbocylic nucleoside analogue selectively inhibit tumor necrosis factor-α production and protect mice against endotoxin challenge. J. Immunol., 151, 389-396.
38. 4. Proc. Natl. Acad. Sci. U.S.A., 81, 3501-3505.
39. PEACHELL, P.T., LICHTENSTEIN, L.M. & SCHLEIMER, R.P. (1991). Differential regulation of human basophil and lung mast cell function by adenosine. J. Pharmacol. Exp. Ther., 256, 717-726.
40. 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem., 268, 16887-16890.
41. ROLA-PLESZCZINSKI, M. & LEMAIRE, I. (1985). Leukotrienes augment interleukin-1 production by human monocytes. J. Immunol., 135, 3958-3961.
42. 4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcription and posttranscriptional mechanisms. Blood, 80, 1004-1011.
43. SAMUELSSON, B., DAHLEN, S.E., LINDGREN, J.A., ROUZER, C.A. & SERHAN, C.N. (1987). Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science (Wash. DC)., 237, 1171-1176.
44. SCHRIER, D.J., LESCH, M.E., WRIGHT, C.D. & GILBERTSEN, R.B. (1990). The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats. J. Immunol., 145, 1874-1879.
45. 4 synthesis ex vivo in neutrophils from patients with rheumatoid arthritis and rheumatism. Arthr. Rheum., 35, 376-384.
46. SURETTE, M.E., ODEIMAT, A., PALMANTIER, R., MARLEAU, S., POUBELLE, P.E. & BORGEAT, P. (1994). Reverse-Phase High Performance liquid chromatography analysis of arachidonic acid metabolites in plasma after stimulation of whole blood ex vivo. Anal. Biochem., 216, 392-400.
47. SURETTE, M.E., PALMANTIER, R., GOSSELIN, J. & BORGEAT, P. (1993). Lipopolysaccarides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen. J. Exp. Med., 178, 1347-1355.
48. 2 receptors. Cell. Signal., 4, 543-551.
49. WOLBERG, G., ZIMMERMAN, T.P., HIENSTRA, K., WINSTON, M. & CHU, L.C. (1975). Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate. Science (Wash. DC), 187, 957-959.
50. 4 enhances activation, proliferation and differentiation of human B lymphocytes. J. Immunol., 143, 1996-2000.
51. YOSHIKAWA, D. & GOTO, F. (1992). Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat - role of the leukocyte. Circ. Shock, 38, 29-33.