GABAergic innervation organizes synaptic and extrasynaptic GABAA receptor clustering in cultured hippocampal neurons

Journal of Neuroscience

Volumn 22, Issue 3, 2002, Pages 684-697

  Christie, Sean B ^a   Miralles, Celia P ^b   De Blas, Angel L ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b NONE   (United States)

Author keywords

Clustering; GABA; GABAA receptor; Gephyrin; Glutamate receptor; Hippocampus; Neuron culture; Subunit isoform; Synapse formation; Synaptogenesis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; GABAERGIC TRANSMISSION; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; INNERVATION; INTERNEURON; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; RABBIT; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; TISSUE DISTRIBUTION;

EID: 0036470774     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-03-00684.2002     Document Type: Article

References (77)

1. Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alphal and alpha3 subunits
2. Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties
3. Chronic blockade of glutamate receptors enhances presynaptic release and downregulates the interaction between synaptophysin-synaptobrevin-vesicle-associated membrane protein 2
4. Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification
5. Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo
6. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function
7. N-cadherin redistribution during synaptogenesis in hippocampal neurons
8. Characterization of GABAergic neurons in hippocampal cell cultures
9. Developmental expression of GABA(A) receptor subunit mRNAs in individual hippocampal neurons in vitro and in vivo
10. Signaling by Eph receptors and their ephrin ligands
11. Stoichiometry of a recombinant GABAA receptor
12. Synaptic and extrasynaptic GABAA receptor and gephyrin clustering
13. Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors
14. Subcellular localization and endocytosis of homomeric gamma2 subunit splice variants of gamma-aminobutyric acid type A receptors
15. Activity and synaptic receptor targeting: The long view
16. Selective clustering of glutamate and gamma-aminobutyric acid receptors opposite terminals releasing the corresponding neurotransmitters
17. Clustering of gephyrin at GABAergic but not glutamatergic synapses in cultured rat hippocampal neurons
18. - channel complex
19. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin
20. A prominent epitope on GABAA receptors is recognized by two different monoclonal antibodies
21. Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer
22. Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse
23. C receptors on mammalian rod bipolar cells
24. A-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
25. Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies
26. A receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts
27. Chloride channel expression with the tandem construct of alpha 6-beta 2 GABAA receptor subunit requires a monomeric subunit of alpha 6 or gamma 2
28. A receptors containing α6 subunits
29. Activity-dependent depression of GABAergic IPSCs in cultured hippocampal neurons
30. Clusters of GABAA receptors on cultured hippocampal cells correlate only partially with functional synapses
31. The subunit composition of a GABAA/benzodiazepine receptor from rat cerebellum
32. Short and long form gamma 2 subunits of the GABAA/benzodiazepine receptors
33. The alpha 1 and alpha 6 subunits can coexist in the same cerebellar GABAA receptor maintaining their individual benzodiazepine-binding specificities
34. A receptor subtypes in developing hippocampal neurons
35. A receptor clustering in gephyrin-deficient mice
36. The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse
37. Gephyrin-independent clustering of postsynaptic gaba(a) receptor subtypes
38. Short communication: Altered synaptic clustering of GABAA receptors in mice lacking dystrophin (mdx mice)
39. Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy
40. A and glycine receptors in the mammalian retina
41. Mobility of synaptic vesicles in nerve endings monitored by recovery from photobleaching of synaptic vesicle-associated fluorescence
42. A receptors and gephyrin expression in cultured motoneurons
43. Coexistence of two beta subunit isoforms in the same gamma-aminobutyric acid type A receptor
44. Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
45. Effect of agrin on the distribution of acetylcholine receptors and sodium channels on adult skeletal muscle fibers in culture
46. Exoendocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons
47. GABAA receptor subtypes immunopurified from rat brain with alpha subunit-specific antibodies have unique pharmacological properties
48. An update on GABAA receptors
49. Fast and reversible trapping of surface glycine receptors by gephyrin
50. Immunocytochemical localization of the beta(3) subunit of the gammaaminobutyric acid(A) receptor in the rat brain
51. Immunocytochemical localization of the beta 2 subunit of the gamma-aminobutyric acidA receptor in the rat brain
52. Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells
53. The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells
54. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
55. A receptors in synapses of hippocampal pyramidal cells of the rat
56. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp
57. Activity-dependent regulation of GABAA receptors
58. Mismatched appositions of presynaptic and postsynaptic components in isolated hippocampal neurons
59. Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites
60. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons
61. Synaptic and extrasynaptic gamma-aminobutyric acid type A receptor clusters in rat hippocampal cultures during development
62. Rat hippocampal neurons in culture: Voltage-clamp analysis of inhibitory synaptic connections
63. Epileptiform activity in microcultures containing one excitatory hippocampal neuron
64. Structural basis of cell-cell adhesion by cadherins
65. Electrophysiological evidence for the coexistence of alphal, alpha6 subunits in a single functional GABA(A) receptor
66. A receptor subunits in the rat hippocampus immunocytochemical distribution of 13 subunits
67. Molecular modification of N-cadherin in response to synaptic activity
68. A receptor β subunits that mediate both homomeric and heteromeric receptor expression
69. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands
70. - channel complex
71. Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses
72. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton
73. Molecular and functional diversity of the expanding GABA-A receptor gene family
74. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
75. Pharmacological and physiological characterization of murine homomeric beta3 GABA(A) receptors
76. A striking organization of a large family of human neural cadherin-like cell adhesion genes