GABA(A) receptor subunits in the rat hippocampus I: Immunocytochemical distribution of 13 subunits

Neuroscience

Volumn 80, Issue 4, 1997, Pages 987-1000

  Sperk, G ^a   Schwarzer, C ^a   Tsunashima, K ^a,b   Fuchs, K ^c   Sieghart, W ^c  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Basket cells; Benzodiazepines; Dentate gyrus; Limbic system; Local circuit neurons

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; CHLORIDE CHANNEL; LIGAND; RECEPTOR SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; GABAERGIC SYSTEM; GRANULE CELL; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; LIGAND BINDING; LIMBIC SYSTEM; MALE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODY SPECIFICITY; CHLORIDE CHANNELS; DENDRITES; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MACROMOLECULAR SUBSTANCES; MALE; NEURONS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

EID: 0030787384     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00146-2     Document Type: Article

References (50)

1. Bliss T. V. P. and Collingridge G. L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
2. Buckwalter M. S., Lossie A. C., Scarlett L. M. and Camper S. A. (1992) Localization of the human chromosome 5q genes GABRA-1, GABRA-2, II-4, II-5 and Irf-1 on mouse chromosome 11. Mamm. Genome 3, 604-607.
3. Buhl E. H., Halasy K. and Somogyi P. (1994) Diverse sources of hippocampal unitary inhibitory postsynaptic potentials and the number of synaptic release sites. Nature 368, 823-828.
4. Cobb S. R., Buhl E. H., Halasy K., Paulsen O. and Somogyi P. (1995) Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature 378, 75-78.
5. 2+. Neuron 5, 781-788.
6. Du F., Williamson J., Bertram E., Lothman E., Okuno E. and Schwarcz R. (1993) Kynurenine pathway enzymes in a rat model of chronic epilepsy: immunohistochemical study of activated glial cells. Neuroscience 55, 975-989.
7. A receptor. Hippocampus 6, 225-238.
8. A receptors is recognized by two different monoclonal antibodies. Brain Res. 569, 57-62.
9. Freund T. F. and Magloczky Z. (1993) Early degeneration of calretinin-containing neurons in the rat hippocampus after ischemia. Neuroscience 56, 581-596.
10. Fritschy J. M., Benke D., Mertens S., Oertel W. H., Bachi T. and Möhler H. (1992) Five subtypes of type A γ-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc. natn. Acad. Sci. U.S.A. 89, 6726-6730.
11. A -receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. comp. Neurol. 359, 154-194.
12. A-benzodiazepine receptor complex purified from the brains of young rats. Fedn Eur. biochem. Socs Lett. 261, 52-54.
13. 1 subunit to neurochemically distinct subpopulations of rat hippocampal interneurons. Eur. J. Neurosci. 6, 837-853.
14. A receptor in the rat brain. J. Neurosci. 14, 7168-7179.
15. Gyenes M., Wang Q., Gibbs T. T. and Farb D. H. (1994) Phosphorylation factors control neurotransmitter and neuromodulator actions at the γ-aminobutyric acid type A receptor. Molec. Pharmac. 46, 542-549.
16. Halasy K. and Somogyi P. (1993) Subdivisions in the multiple GABAergic innervation of granule cells in the dentate gyrus of the rat hippocampus. Eur. J. Neurosci. 5, 411-429.
17. Han Z.-S., Buhl E. H., Lörinczi Z. and Somogyi P. (1993) A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurones in the dentate gyrus of the rat hippocampus. Eur. J. Neurosci. 5, 395-410.
18. A receptor α6 subunit gene inactivation inhibits δ subunit expression. J. Neurosci. 17, 1350-1362.
19. 2S γ-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. J. biol. Chem. 267, 25,660-25,663.
20. A receptors identify a 67-kDa protein in rat brain membranes. J. Neurochem. 62, 764-769.
21. A receptor function by protein kinase C phosphorylation. Neuron 12, 1081-1095.
22. Mitchell J., Sundstrom L. E. and Wheal H. V. (1993) Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injection. Expl Neurol. 121, 224-230.
23. Mody I., De Koninck Y., Otis T. S. and Soltesz I. (1994) Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 17, 517-525.
24. A-receptors: cell-specific expression, pharmacology, and regulation. Neurochem. Res. 20, 631-636.
25. A receptor in the rat brain. J. comp. Neurol. 350, 260-271.
26. 1-subunits. J. biol. Chem. 269, 25,777-25,782.
27. Niquet J., Jorquera I., Ben-Ari Y. and Represa A. (1994) Proliferative astrocytes may express fibrinonectin-like protein in the hippocampus of epileptic rats. Neurosci. Lett. 180, 13-16.
28. A receptor in relation to specific GABAergic synapses in the dentate gyrus. Eur. J. Neurosci. 7, 630-646.
29. A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J. Neurosci., 16, 103-114.
30. A receptor subunits in the rat CNS. J. comp. Neurol. 326, 193-216.
31. A receptor isoform. Genomics 23, 528-533.
32. 2 subunits of the γ-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome. Proc. natn. Acad. Sci. U.S.A. 89, 5857-5861.
33. A -Receptors in the rat hippocampus II: Altered subunit distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience, 80, 1001-1007.
34. A receptor subtypes. Pharmac. Rev. 47, 181-234.
35. A receptor in the rat brain. J. Neurochem. 60, 93-98.
36. Sommer W. (1880) Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie. Arch. Psychiat. Nervenkr. 10, 631-675.
37. Sperk G., Marksteiner J., Gruber B., Bellmann R., Mahata M. and Ortler M. (1992) Functional changes in neuropeptide Y and somatostatin containing neurons induced by limbic seizures in the rat. Neuroscience 50, 831-846.
38. A receptors. Biochem. J. 310, 1-9.
39. Sternberger L. (1979) Immunohistochemistry. 2nd edn, John Wiley and Sons, New York.
40. A receptor: dependence on receptor subunit combination. Br. J. Pharmac. 117, 521-527.
41. Todd A. J., Watt C., Spike R. C. and Sieghart W. (1996) Co-localization of GABA, glycine and their receptors at synapses in the rat spinal cord. J. Neurosci. 16, 974-982.
42. 2/3 and different α-subunits exhibit unique pharmacological properties. J. biol. Chem. 269, 12,993-12,998.
43. A receptor subunits in the rat hippocampus III: altered expression of their mRNAs in kainic acid-induced epilepsy. Neuroscience 80, 1019-1032.
44. 4 subunit. Fedn Eur. biochem. Socs Lett. 289, 227-230.
45. A receptor subunit mRNAs in the rat brain I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12, 1040-1062.
46. Woods J. H., Katz J. L. and Winger G. (1992) Benzodiazepines: use, abuse, and consequences. Pharmac. Rev. 44, 151-347.
47. Woodward R. M., Polenzani L. and Miledi R. (1991) Effects of steroids on γ-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina. Molec. Pharmac. 41, 89-103.
48. A benzodiazepine receptor complex by immunoaffinity chromatography. Brain Res. 563, 325-328.
49. A-benzodiazepine receptors by immunoaffinity chromatography. Fedn Eur. biochem. Socs Lett. 284, 15-18.
50. A receptor in the rat brain. Neurosci. Lett. 127, 125-128.