Trafficking of MHC class II molecules in the late secretory pathway

Current Opinion in Immunology

Volumn 14, Issue 1, 2002, Pages 30-35

  Hiltbold, Elizabeth M ^a   Roche, Paul A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BIOSYNTHESIS; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELL SECRETION; CELL SURFACE; CELL TYPE; DENDRITIC CELL; ENDOPLASMIC RETICULUM; ENDOSOME; IMMUNE SYSTEM; INTERNALIZATION; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROORGANISM; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; TRANS GOLGI NETWORK;

EID: 0036467586     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(01)00295-3     Document Type: Review

References (62)

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4. Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum
5. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules
6. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression
7. Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain
8. Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP)
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13. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
14. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules
15. CIIV, MIIC and other compartments for MHC class II loading
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18. How MHC class II molecules reach the endocytic pathway
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20. Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments
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24. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
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26. Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments
27. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
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29. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein
30. Editing of recycling class II: Peptide complexes by HLA-DM
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32. Molecular bases for the recognition of tyrosine-based sorting signals
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34. A novel adaptor-related protein complex
35. Association of the AP-3 adaptor complex with clathrin
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41. Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence
42. The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation
43. Proteases involved in MHC class II antigen presentation
44. B lymphocytes secrete antigen-presenting vesicles
45. Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface
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48. Regulated secretion from hemopoietic cells
49. Exosome: From internal vesicle of the multivesicular body to intercellular signaling device
50. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
51. Dendritic cells: Specialized and regulated antigen processing machines
52. The cell biology of antigen presentation in dendritic cells
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54. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
55. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes
56. Invariant chain retains MHC class II molecules in the endocytic pathway
57. Role for intracellular proteases in the processing and transport of class II HLA antigens
58. MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
59. Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation
60. Developmental control of endocytosis in dendritic cells by Cdc42
61. Interleukin-10 down-regulates MHC class II alpha beta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling
62. Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells