Effects of ethanol on calcium homeostasis in the nervous system: Implications for astrocytes

Molecular Neurobiology

Volumn 19, Issue 1, 1999, Pages 1-24

  Catlin, Michelle C ^a   Guizzetti, Marina ^a   Costa, Lucio G ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alcohol tolerance; Astrocytes; Calcium; Calcium channels; Ethanol; Fetal alcohol syndrome; G proteins; Nervous system

Indexed keywords

ALCOHOL; CALCIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN;

ALCOHOL ABUSE; ALCOHOL TOLERANCE; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; FETAL ALCOHOL SYNDROME; HUMAN; NEUROTOXICITY; NONHUMAN; PRENATAL EXPOSURE; TERATOGENICITY;

EID: 0032937280     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02741375     Document Type: Article

References (178)

1. United States Department of Health and Human Services (1990) Seventh Special Report to the US Congress on Alcohol and Health. Secretary of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD.
2. Diamond, I. and Gordon, A. S. (1997) Cellular and molecular neuroscience of alcoholism. Physiol. Rev. 77, 1-19.
3. Bloom, F. E. (1997) The science of substance abuse. Science 278, 15.
4. Little, H. J. (1991) Mechanisms the may underlie the behavioural effects of ethanol. Prog. Neurobiol. 36, 171-194.
5. Cotran, R. S., Kumar, V., and Robbins, S. L. (1994) Environmental and nutritional diseases, in Robbin's Pathologic Basis of Disease, 5th ed., Saunders, Philadelphia, pp. 379-430.
6. Jones, K. L., Smith, D. W., Ulleland, C. N., and Streissguth, A. (1973) Pattern of malformation in offspring of chronic alcoholic mothers. Lancet 7815, 1267-1271.
7. Clarren, S. K, and Smith, D. W. (1978) The fetal alcohol syndrome. N. Engl. J. Med. 298, 1063-1067.
8. Streissguth, A. P., Aase, J. M., Clarren, S. M., Randels, S. P., LaDue, R. A., and Smith, D. F. (1991) Fetal alcohol syndrome in adolescents and adults. JAMA 265, 1961-1967.
9. Lemoine, P. and Lemoine, P. (1992) Avénir des enfants de mères alcooliques (étude de 105 cas retrouvés à l'age adulte) et quelques constatations d'intérêt prophylactique. Ann. Pediatr. (Paris) 39, 226-235.
10. Spohr, H. L., Willms, J., and Steinhausen, H. C. (1993) Prenatal alcohol exposure and long-term developmental consequences. Lancet 341, 907-910.
11. CCD (Centers of Disease Control) (1995) Trends in fetal alcohol syndrome-United States. MMWR 44, 249-251.
12. Tabakoff, B., Hoffman, P. L., and McLaughlin, A. (1988) Is ethanol a discriminating substance? Semin. Liver Dis. 8, 26-35.
13. Weight, F. F. (1992) Cellular and molecular physiology of alcohol actions in the nervous system. Int. Rev. Neurobiol. 33, 289-348.
14. Costa, L. G. (1994) Signal transduction mechanisms in developmental neurotoxicity: The phosphoinositide pathway. Neurotoxicology 15, 19-27.
15. Eggeman, K. T. and Browning, M. D. (1996) Ethanol and the phosphorylation of ligand-gated ion channels, in Pharmacological Effects of Ethanol on the Nervous System (Dietrich, R. A., ed.), CRC, Boca Raton, FL, pp. 117-133.
16. Clapham, D. E. (1995) Calcium signaling. Cell 80, 259-268.
17. Ghosh, A. and Greenberg, M. E. (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268, 239-247.
18. Pozzan, T., Rizzuto, R., Volpe, P., and Meldolesi, J. (1994) Molecular and cellular physiology of intracellular stores. Physiol. Rev. 74, 595-636.
19. DeWaard, M., Gurnett, C. A., and Campbell, K. P. (1996) Structural and functional diversity of voltage-activated calcium channels, in Ion Channels, (Narahashi, T., ed.), Plenum, New York, pp. 41-60.
20. 2+ and the regulation of early response gene expression in HL-60 myeloid leukemia cells. J. Biol. Chem. 268, 16,596-16601.
21. Sheng, M. and Greenberg, M. E. (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4, 477-485.
22. Herschman, H. R. (1991) Primary response genes induced by growth factors and tumor promoters. Annu. Rev. Biochem. 60, 281-319.
23. Kovary, K. and Bravo, R. (1991) The Jun and Fos protein families are both required for cell cycle progression in fibroblasts. Mol. Cell Biol. 11, 4466-4472.
24. 2+ channel blocker. Cancer Lett. 72, 77-81.
25. Nicotera, P., Zhivotovsky, B., and Orrenius, S. (1994) Nuclear calcium transport and the role of calcium in apoptosis. Cell Calcium 16, 279-288.
26. Lee, N. M. and Becker, C. E. (1992) The alcohols, in Basic and Clinical Pharmacology (Katzung B. G., ed.), Appleton & Lange, East Norwalk, CT, pp. 737-771.
27. Clarke, D. W., Steenaart, N. A. E., and Brien, J. F. (1986) Disposition of ethanol and activity of hepatic and placental alcohol dehydrogenase and aldehyde dehydrogenases in the third-trimester pregnant guinea pig for single and short-term oral ethanol administration. Alcohol. Clin. Exp. Res. 10, 330-336.
28. Clarke, D. W., Steenaart, N. A. E., Slack, C. J., and Brien, J. F. (1986) Pharmacokinetics of ethanol and its metabolite, acetaldehyde, and fetolethality in the third-trimester pregnant guina pig for oral administration of acute, multiple-dose ethanol. Can. J. Physiol. Pharmacol. 64, 1060-1067.
29. Snyder, R. and Andrews, L. S. (1996) Toxic effects of solvents and vapours, in Casarett & Doull's Toxicology. The Basic Science of Poisons (Katzung B. G., ed.), 5th ed., McGraw-Hill, New York, pp. 737-771.
30. Morgan, D. L., Durso, M. H., Rich, B. K., and Kurt, T. L. (1995) Severe ethanol intoxication in an adolescent. Am. J. Emerg. Med. 13, 416-418.
31. Johnson, R. A., Noll, E. C., and Rodney, W. M. (1982) Survival after a serum ethanol concentration of 1 1/2%. Lancet 2, 1394.
32. Jones, A. W. and Sternebring, B. (1992) Kinetics of ethanol and methanol in alcoholics during detoxification. Alcohol Alcohol. 27, 641-647.
33. Adachi, J., Mizoi, Y., Fukunaga, T., Ogawa, Y., and Imamichi, H. (1989) Comparative study on ethanol elimination and blood acetaldehyde between alcoholics and control subjects. Alcohol. Clin. Exp. Res. 13, 601-604.
34. Catlin, M. C., Abdollah, S., and Brien, J. F. (1993) Dose-dependent effects of prenatal ethanol exposure in the guinea pig. Alcohol 10, 109-115.
35. Abdollah, S., Catlin, M. C., and Brien, J. F. (1993) Ethanol neuro-behavioural teratogenesis in the guinea pig: Behavioural dysfunction and hippocampal morphologic changes. Can. J. Physiol. Pharmacol. 71, 776-782.
36. West, J. R., Hamre, K. M., and Cassell, M. D. (1986) Effects of ethanol exposure during the third trimester equivalent on neuron number in rat hippocampus and dentate gyrus. Alcohol. Clin. Exp. Res. 10, 190-197.
37. Moloney, B. and Leonard, B. E. (1984) Pre-natal and post-natal effects of alcohol in the rat. I. changes in body weight and exploratory activity. Alcohol Alcohol 19, 131-136.
38. Finkbeiner, S. M. (1993) Glial calcium. Glia 9, 83-104.
39. 2+ mobilization by okadaic acid in rat hepatocytes: Evidence for a role of protein phosphatases in the modulation of phospholipase C by ethanol. Alcohol Alcohol. 29, 53-59.
40. Hoek, J. B., Thomas, A. P., Rooney, T. A., Higashi, K., and Rubin, E. (1992) Ethanol and signal transduction in the liver. FASEB J. 6, 2386-2396.
41. Rabe, C. S. and Weight, F. F. (1988) Effects of ethanol on neurotransmitter release and intracellular free calcium in PC12 cells. J. Pharmacol. Exp. Ther. 244, 417-422.
42. 2+ in dissociated brain cells. Brain Res. 499, 383-387.
43. Snell, L. D., Tabakoff, B., and Hoffman, P. L. (1994) Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol. Clin. Exp. Res. 18, 81-85.
44. Daniell, L. C., Brass, E. P., and Harris, R. A. (1987) Effect of ethanol on intracellular ionized calcium concentrations in synaptosomes and hepatocytes. Mol. Pharmacol. 32, 831-837.
45. Rezazadeh, S. M., Woodward, J. J., and Leslie, S. W. (1989) Fura-2 measurement of cytosolic free calcium in rat brain cortical synaptosomes and the influence of ethanol. Alcohol 6, 341-345.
46. 2+ levels in undifferentiated PC12 cells. Cell. Signal. 7, 389-395.
47. Webb, B., Suarez, S. S., Heaton, M. B., and Walker, D. W. (1995) Ethanol and nerve growth factor effects on calcium homeostasis in cultured embryonic rat medial septal neurons before and during depolarization. Brain Res. 701, 61-74.
48. Webb, B., Suarez, S. S., Heaton, M. B., and Walker, D. W. (1996) Cultured postnatal rat medical septal neurons respond to acute ethanol treatment and nerve growth factor by changing intracellular calcium levels. Alcohol. Clin. Exp. Res. 20, 1385-1394.
49. Webb, B., Suarez, S. S., Heaton, M. B., and Walker, D. W. (1996) Calcium homeostasis in cultured embryonic rat septohippocampal neurons is altered by ethanol and nerve growth factor before and during depolarization. Brain Res. 729, 176-189.
50. 2+ mobilization in rat hippocampal cells are mediated by protein kinase C. Brain Res. 714, 27-37.
51. Davidson, M., Wilce, P., and Shanley, B. (1988) Ethanol increases synaptosomal free calcium concentration. Neurosci. Lett. 89, 165-169.
52. Fano, G., Belia, S., Mariggio, M. A., Antonica, A., Agea, E., and Spinozzi, F. (1993) Alteration of membrane transductive mechanisms induced by ethanol in human lymphocyte cultures. Cell. Signal. 5, 139-143.
53. Cofan, M., Fernandez-Sola, J., Nicolas, J. M., Poch, E., and Urbano-Marquez, A. (1995) Ethanol decreases basal cytosolic-free calcium concentration in cultured skeletal muscle cells. Alcohol Alcohol. 30, 617-621.
54. Kovacs, K. A., Kavanagh, T. J., and Costa, L. G. (1995) Ethanol inhibits muscarinic receptor-stimulated phosphoinositide metabolism and calcium mobilization in rat primary cortical cultures. Neurochem. Res. 20, 939-949.
55. Catlin, M. C., Guizzetti, M., and Costa, L. G. (1999) Effect of ethanol on muscarinic-induced calcium responses in astroglia. In preparation.
56. Messing, R. O., Sneade, A. B., and Savidge, B. (1990) Protein kinase C participates in up-regulation of dihydropyridine-sensitive calcium channels by ethanol. J. Neurochem. 55, 1383-1389.
57. Zou, J. Y., Cohan, C., Rabin, R. A., and Pentney, R. J. (1995) Continuous exposure of cultured rat cerebellar macroneurons to ethanol-depressed NMDA and KCl-stimulated elevations of intracellular calcium. Alcohol. Clin. Exp. Res. 19, 840-845.
58. Grant, A. J., Koski, G., and Treistman, S. N. (1993) Effect of chronic ethanol on calcium currents and calcium uptake in undifferentiated PC12 cells. Brain Res. 600, 280-284.
59. Blevins, T., Mirshahi, T., and Woodward, J. J. (1995) Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci. Lett. 200, 214-218.
60. Holownia, A., Ledig, M., and Menez, J. F. (1997) Ethanol-induced cell death in cultured rat astroglia. Neurotoxiol. Teratol. 19, 141-146.
61. Harris, R. A. and Hood, W. F. (1980) Inhibition of synaptosomal calcium uptake by ethanol. J. Pharmacol. Exp. Ther. 213, 562-568.
62. Leslie, S. W., Barr, E., Chandler, J., and Farrar, R. P. (1983) Inhibition of fast- and slow-phase depolarization-dependent synaptosomal calcium uptake by ethanol. J. Pharmacol. Exp. Ther. 225, 571-575.
63. Lee, Y. H., Spuhler-Phillips, K., Randall, P. K., and Leslie, S. W. (1996) Effects of prenatal ethanol exposure on voltage-dependent calcium entry into neonatal whole brain-dissociated neurons. Alcohol. Clin. Exp. Res. 20, 921-928.
64. Verkhratsky, A., Orkand, R. K., and Kettenmann, H. (1998) Glial calcium: Homeostasis and signaling function. Physiol. Rev. 78, 99-141.
65. MacVicar, B. A. (1984) Voltage-dependent calcium channels in glial cells. Science 226, 1345-1347.
66. Sontheimer, H. (1994) Voltage-dependent ion channels in glial cells. Glia 11, 156-172.
67. Langley, D. and Pearce, B. (1994) Ryanodine-induced intracellular calcium mobilization in cultured astrocytes. Glia 12, 128-134.
68. 2+ stores in astrocytes: Role of the plasmalemmal Na/Ca exchanger. Glia 16, 296-305.
69. Sontheimer, H. (1992) Astrocytes, as well as neurons, express a diversity of ion channels. Can. J. Physiol. Pharmacol. 70, S223-S238.
70. Verkhratsky, A. and Kettenmann, H. (1996) Calcium signalling in glial cells. Trends Neurosci. 19, 346-352.
71. Leslie, S. W., Brown, L. M., Dildy, J. E., and Sims, J. S. (1990) Ethanol and neuronal calcium channels. Alcohol 7, 233-236.
72. 2+ sensitivity. Nature 303, 175, 176.
73. Messing, R. O., Carpenter, C. L., Diamond, I., and Greenberg, D. A. (1986) Ethanol regulates calcium channels in clonal neural cells. Proc. Natl. Acad. Sci. USA 83, 6213-6215.
74. 2+ channels in PC12 cells: Role of permanent ions. Eur. J. Pharmacol. 270, 17-25.
75. ++ channels by ethanol in undifferentiated and nerve growth factor-treated PC12 cells: Interaction with the inactivated state. J. Pharmacol. Exp. Ther. 272, 489-497.
76. Oakes, S. G. and Pozos, R. S. (1982) Electrophysiologic effects of acute ethanol exposure. II. Alterations in the calcium component of action potentials from sensory neurons in dissociated culture. Dev. Brain Res. 5, 251-255.
77. Camacho-Nasi, P. and Treistman, S. N. (1986) Ethanol effects on voltage-dependent membrane conductances: Comparative sensitivity of channel populations in Aplysia neurons. Cell. Mol. Neurobiol. 6, 263-279.
78. Twombly, D. A., Herman, M. D., Kye, C. H., and Narahashi, T. (1990) Ethanol effects on two types of voltage-activated calcium channels. J. Pharmacol. Exp. Ther. 254, 1029-1037.
79. Camacho-Nasi, P. and Treistman, S. N. (1987) Ethanol-induced reduction of neuronal calcium currents in Aplysia: An examination of possible mechanisms. Cell. Mol. Neurobiol. 7, 191-207.
80. Ruis, R. A., Bergamaschi, S., DiFonso, F., Govoni, S., Trabucchi, M., and Rossi, F. (1987) Acute ethanol effect on calcium antagonist binding in rat brain. Brain Res. 402, 359-361.
81. o in the suppressant effect of ethanol on voltage-activated calcium channels of murine sensory neurons. Alcohol. Clin. Exp. Res. 18, 608-615.
82. i is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells. Mol. Pharmacol. 47, 997-1005.
83. Canda, A., Yu, B. H., and Sze, P. Y. (1995) Biochemical characterization of ethanol actions on dihydropyridine-sensitive calcium channels in brain synaptosomes. Biochem. Pharmacol. 50, 1711-1718.
84. 2+ channel modulating drugs. Brain Res. 410, 143-146.
85. Gruol, D. L. and Parsons, K. L. (1994) Chronic exposure to alcohol during development alters the calcium currents of cultured cerebellar Purkinje neurons. Brain Res. 634, 283-290.
86. Marks, S. S., Watson, D. L., Carpenter, C. L., Messing, R. O., and Greenberg, D. A. (1989) Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium channel antagonist receptor in cultured neural PC12 cells. J. Neurochem. 53, 168-172.
87. 2+ uptake in synaptosomes and in PC12 cells. Biochem. Pharmacol. 36, 2227-2229.
88. Dolin, S. J. and Little, H. J. (1989) Are changes in neuronal calcium channels involved in ethanol tolerance? J. Pharmacol. Exp. Ther. 250, 985-991.
89. 3H]-nitrendipine in tissues from ethanol-dependent rats. Alcohol Alcohol. 29, 283-293.
90. Guppy, L. J., Crabbe, J. C., and Littleton, J. M. (1995) Time course and genetic variation in the regulation of calcium channel antagonist binding sites in rodent tissues during the induction of ethanol physical dependence and withdrawal. Alcohol Alcohol. 30, 607-615.
91. Bergamaschi, S., Battaini, F., Trabucchi, M., Parenti, M., Lopez, C. M., and Govoni, S. (1995) Neuronal differentiation modifies the effect of ethanol exposure on voltage-dependent calcium channels in NG 108-15 cells. Alcohol 12, 497-503.
92. Little, H. J., Dolin, S. J., and Halsey, M. J. (1986) Calcium channel antagonists decrease the ethanol withdrawal syndrome. Life Sci. 39, 2059-2065.
93. Whittington, M. A., Dolin, S. J., Patch, T. L., Siarey, R. J., Butterworth, A. R., and Little, H. J. (1991) Chronic dihydropyrindine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment. Br. J. Pharmacol. 103, 1669-1676.
94. Crews, F. T., Morrow, A. L., Criswell, H., and Breese, G. (1996) Effects of ethanol on ion channels. Int. Rev. Neurobiol. 39, 283-367.
95. Hoffman, P. L. and Tabakoff, B. (1996) Alcohol dependence: A commentary on mechanisms. Alcohol Alcohol. 31, 333-340.
96. Blankenfeld, G. V., Enkvist, K., and Kettenmann H. (1995) Gamma-aminobutyric acid and glutamate receptors, in Neuroglia (Kettenmann H. and Ranson B. R., eds.), Oxford University Press, New York, pp. 335-345.
97. Porter, J. T. and McCarthy, K. D. (1997) Astrocytic neurotransmitter receptors in situ and in vivo. Prog. Neurobiol. 51, 439-455.
98. Gruol, D. L. and Curry, J. G. (1995) Calcium signals elicited by quisqualate in cultured Purkinje neurons show developmental changes in sensitivity to acute alcohol. Brain Res. 673, 1-12.
99. Gruol, D. L. and Parsons, K. L. (1996) Chronic alcohol reduces calcium signaling elicited by glutamate receptor stimulation in developing cerebellar neurons. Brain Res. 728, 166-174.
100. 2+ channel in Drosophila photoreceptors. Neuron 8, 643-651.
101. 2+ entry. Cell 85, 661-671.
102. Philipp, S., Cavalie, A., Freichel, M., Wissenbach, U., Zimmer, S., Trost, C., Marquart, A., Murakami, M., and Flockerzi, V. (1996) A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J. 15, 6166-6171.
103. 2+ and trp. Cell Calcium 18, 256-274.
104. 2+ entry. Mol. Neurobiol. 12, 163-180.
105. Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., and Watson, J. D. (1989) Cell signalling, in Molecular Biology of the Cell, 2nd ed. (Alberts B., Bray D., Lewis J., Raff M., Roberts K., and Watson J. D., eds.), Garland Publishing, New York, pp. 681-726.
106. Balduini, W. and Costa, L. G. (1990) Developmental neurotoxicity of ethanol: In vitro inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in brain from neonatal but not adult rats. Brain Res. 512, 248-252.
107. Balduini, W., Candura, S. M., Manzo, L., Cattabeni, F., and Costa, L. G. (1991) Time-, concentration-, and age-dependent inhibition of muscarinic receptor-stimulated phosphoinositide metabolism by ethanol in the developing rat brain. Neurochem. Res. 16, 1235-1240.
108. Candura, S. M., Manzo, L., and Costa, L. G. (1992) Inhibition of muscarinic receptor- and G-protein-dependent phosphoinositide metabolism in cerebrocortical membranes from neonatal rats by ethanol. Neurotoxicology 13, 281-288.
109. Larsson, C., Simonsson, P., Hoek, J. B., and Alling, C. (1995) Ethanol inhibits the peak of muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate in neuroblastoma SH-SY5Y cells. Biochem. Pharmacol. 50, 647-654.
110. Smith, T. L., Yamamura, H. I., and Lee, L. (1986) Effect of ethanol on receptor-stimulated phosphatidic acid and polyphosphoinositide metabolism in mouse brain. Life Sci. 39, 1675-1684.
111. Balduini, W. and Costa, L. G. (1989) Effects of ethanol on muscarinic receptor-stimulated phosphoinositide metabolism during brain development. J. Pharmacol. Exp. Ther. 250, 541-547.
112. Simonsson, P., Sun, G. Y., Vecsei, L., and Alling, C. (1989) Ethanol effects on bradykinin-stimulated phosphoinositide hydrolysis in NG 108-15 neuroblastoma-glioma cells. Alcohol 6, 475-479.
113. Ritchie, T., Kim, H.-S., Cole, R., DeVellis, J., and Noble, E. P. (1988) Alcohol-induced alterations in phosphoinositide hydrolysis in astrocytes. Alcohol 5, 183-187.
114. Smith, T. L. and Bitrick, M. S. (1995) Lack of involvement of protein kinase C in ethanol-induced inhibition of metabotropic-glutamate receptor function in primary cultures of astrocytes. Life Sci. 56, PL485-489.
115. Koski, G., Lawrence, K., and Righi, D. (1991) Ethanol-induced inhibition of carbachol-stimulated uptake of calcium in PC12 pheochromocytoma cells. Neuropharmacology 30, 267-274.
116. Larsson, C. Ethanol and muscarinic receptor-stimulated signal transduction in nerve cells. in Ph.D. thesis, University of Lund, 1995.
117. Higashi, K. and Hoek, J. B. (1991) Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes. J. Biol. Chem. 266, 2178-2190.
118. 2+ mobilization in rat hepatocytes. Alcohol. Clin. Exp. Res. 20, 330A-334A.
119. Simonsson, P., Rodriguez, F. D., Loman, N., and Alling, C. (1991) G proteins coupled to phospholipase C: Molecular targets of long-term ethanol exposure. J. Neurochem. 56, 2018-2026.
120. qα/11α in NG108-15 cells. J. Neurochem. 61, 1163-1166.
121. q/11α subunit protein and phospholipase C isozymes in the rat brain. J. Neurochem. 67, 2355-2361.
122. Smith, T. L. (1994) Selective effects of ethanol exposure on metabotropic glutamate receptor and guanine nucleotide stimulated phospholipase C activity in primary cultures of astroctyes. Alcohol 11, 405-409.
123. q/11-protein in primary cultures of astrocytes. Alcohol 13, 487-492.
124. Ilyin, V. and Parker, I. (1992) Effects of alcohols on responses evoked by inositol trisphosphate in Xenopus oocytes. J. Physiol. 448, 339-354.
125. 2+ channel by ethanol and other aliphatic alcohols. Biochem. J. 314, 175-179.
126. 3H]inositol 1,4,5-trisphosphate to rat cerebellar membranes. Alcohol Alcohol. 31, 453-461.
127. 3 3-kinase and mGluR1 in mouse Purkinje neurons. Neuro Report 7, 2115-2118.
128. Travis, J. (1994) Glia: The brain's other cells. Science 266, 970-972.
129. McCarthy, K. D. and DeVellis, J. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902.
130. Bhat, N. R. (1995) Signal transduction mechanisms in glial cells. Dev. Neurosci. 17, 267-284.
131. Rudge, J. S., Alderson, R. F., Pasnikowski, E., McClain, J., Ip, N. Y., and Lindsay, R. M. (1992) Expression of ciliary neurotrophic factor and the neurotrophins-nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3-in cultured rat hippocampal astrocytes. Eur. J. Neurosci. 4, 459-471.
132. Ashkenazi, A., Ramachandran, J., and Capon, D. J. (1989) Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes. Nature 340, 146-150.
133. Guizzetti, M., Costa, P., Peters, J., and Costa, L. G. (1996) Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells. Eur. J. Pharmacol. 297, 265-273.
134. Tropea, M., Johnson, M. I., and Higgins, D. (1988) Glial cells promote dendritic development in rat sympathetic neurons in vitro. Glia 1, 380-392.
135. Selinfreund, R. H., Barger, S. W., Welsh, M. J., and Van Eldik, L. J. (1990) Antisense inhibition of glial S100β production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation. J. Cell Biol. 111, 2021-2028.
136. 2+ oscillations. Brain Res. 659, 169-178.
137. Hosoya, T., Takizawa, K., Nitta, K., and Hotta, Y. (1995) Glial cells missing: A binary switch between neuronal and glial determination in Drosophila. Cell 82, 1025-1036.
138. Jones, B. W., Fetter, R. D., Tear, G., and Goodman, C. S. (1995) Glial cells missing: a genetic switch that controls glial versus neuronal fate. Cell 82, 1013-1023.
139. Xiong, W.-C. and Montell, C. (1995) Defective glia induce neuronal apoptosis in the repo visual system of Drosophila. Neuron 14, 581-590.
140. Altshuller, Y., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Frohman, M. A. (1996) Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett. 393, 201-204.
141. Akiyama, Y., Hosoya, T., Poole, A. M., and Hotta, Y. (1996) The gcm-motif: A novel DNA-binding motif conserved in drosophila and mammals. Proc. Natl. Acad. Sci. USA 93, 14,912-14,916.
142. Murphy, T. H., Blatter, L. A., Wier, W. G., and Baraban, J. M. (1993) Rapid communication between neurons and astrocytes in primary cortical cultures. J. Neurosci. 13, 2672-2679.
143. Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., and Smith, S. J. (1990) Glutamate induces calcium waves in cultured astrocytes: Long-range glial signaling. Science 247, 470-473.
144. Charles, A. C. (1994) Glia-neuron intercellular calcium signaling. Dev. Neurosci. 16, 196-206.
145. Nedergaard, M. (1994) Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 263, 1768-1771.
146. Dani, J. W., Chernjavsky, A., and Smith, S. J. (1992) Neuronal activity triggers calcium waves in hippocampal astrocyte networks. Neuron 8, 429-440.
147. Keyser, D. O. and Pellmar, T. C. (1994) Synaptic transmission in the hippocampus: Critical role for glial cells. Glia 10, 237-243.
148. Mennerick, S., Benz, A., and Zorumski, C. F. (1996) Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures. J. Neurosci. 16, 55-64.
149. Charles, A. C., Merrill, J. E., Dirksen, E. R., and Sanderson, M. J. (1991) Intercellular signaling in glial cells: Calcium waves and oscillations in response to mechanical stimulation and glutamate. Neuron 6, 983-992.
150. 2+ waves in astrocytes. Cell Calcium 12, 185-204.
151. Enkvist, M. O. K. and McCarthy, K. D. (1992) Activation of protein kinase C blocks astroglial gap junction communication and inhibits the spread of calcium waves. J. Neurochem. 59, 519-526.
152. Palfrey, H. C. and Nairn, A. C. (1995) Calcium-dependent regulation of protein synthesis. Adv. Second Messenger Phosphoprotein Res. 30, 191-223.
153. Rosen, L. B., Ginty, D. D., and Greenberg, M. E. (1995) Calcium regulation of gene expression. Adv. Second Messenger Phosphoprotein Res. 30, 225-253.
154. Kovary, K. and Bravo, R. (1991) Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: In vitro and in vivo associations. Mol. Cell Biol. 11, 2451-2459.
155. Bennett, A. M. and Williams, G. M. (1993) calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate. Biochem. Pharmacol. 46, 2219-2227.
156. 2+ stores in cell cycle progression at the G1/S boundary in serum-stimulated human fibroblasts. FEBS Lett. 360, 173-176.
157. 2+ pool content is linked to control of cell growth. Proc. Natl. Acad. Sci. USA 90, 4986-4990.
158. Hosli, E. and Hosli, L. (1993) Receptors for neurotransmitters on astrocytes in the mammalian central nervous system. Prog. Neurobiol. 40, 477-506.
159. Hosli, L., Hosli, E., Maelicke, A., and Schroder, H. (1992) Peptidergic and cholinergic receptors on cultured astrocytes of different regions of the rat CNS. Prog. Brain Res. 94, 317-329.
160. Van Der Zee, E. A., DeJong, G. I., Strosberg, A. D., and Luiten, P. G. M. (1993) Muscarinic acetylcholine receptor-expression in astrocytes in the cortex of young and aged rats. Glia 8, 42-50.
161. Brown-Masters, S., Harden, T. K., and Brown, J. H. (1984) Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. Mol. Pharmacol. 26, 149-155.
162. Kim, W. T., Rioult, M. G., and Cornell-Bell, A. H. (1994) Glutamate-induced calcium signaling in astrocytes. Glia 11, 173-184.
163. Gafni, J., Munsch, J. A., Lam, T. H., Catlin, M. C., Costa, L. G., Molinski, T. F., and Pessah, I. N. (1997) Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 19, 723-733.
164. Smith, S. J. (1992) Do astrocytes process neural information? Prog. Brain Res. 94, 119-136.
165. Pende, M., Fisher, T. L., Simpson, P. B., Russell, J. T., Blenis, J., and Gallo, V. (1997) Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: Role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway J. Neurosci. 17, 1291-1301.
166. 2+ oscillations. Science 279, 227-230.
167. Blackshear, P. J., Stumpo, D. J., Huang, J., Nemenoff, R. A., and Spach, D. H. (1987) Protein kinase C-dependent and -independent pathways of protooncogene induction in human astrocytoma cells. J. Biol. Chem. 262, 7774-7781.
168. Arenander, A. T., de Vellis, J., and Herschman, H. R. (1989) Induction of c-fos and TIS genes in cultured rat astrocytes by neurotransmitters. J. Neurosci. Res. 24, 107-114.
169. Pende, M., Holtzclaw, L. A., Curtis, J. L., Russell, J. T., and Gallo, V. (1994) Glutamate regulates intracellular calcium and gene expression in oligodendrocyte progenitors through the activation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Proc. Natl. Acad. Sci. USA 91, 3215-3219.
170. Martin, F. C., Charles, A. C., Sanderson, M. J., and Merrill, J. E. (1992) Subtance P stimulates IL-1 production by astrocytes via intracellular calcium. Brain Res. 599, 13-18.
171. Parpura, V., Basarsky, T. A., Liu, F., Jeftinija, K., Jeftinija, S., and Haydon, P. G. (1994) Glutamate-mediated astrocyte-neuron signalling. Nature 369, 707-708.
172. Jeftinija, S. D., Jeftinija, K. V., Stefanovic, G., and Liu, F. (1996) Neuroligand-evoked calcium-dependent release of excitatory amino acids from cultured astrocytes. J. Neurochem. 66, 676-684.
173. MacVicar, B. A. (1987) Morphological differentiation of cultured astrocytes in blocked by cadmium or cobalt. Brain Res. 420, 175-177.
174. Goldman, R. S., Finkbeiner, S. M., and Smith, S. J. (1991) Endothelin induces a sustained rise in intracellular calcium in hippocampal astrocytes. Neurocsi. Lett. 123, 4-8.
175. Stiene-Martin, A., Mattson, M. P., and Hauser, K. F. (1993) Opiates selectively increase intracellular calcium in developing type-1 astrocytes: Role of calcium in morphine-induced morphologic differentiation. Dev. Brain Res. 76, 189-196.
176. Resnicoff, M., Cui, S., Coppola, D., Hoek, J. B., and Rubin, R. (1996) Ethanol-induced inhibition of cell proliferation is modulated by insulin-like growth factor-I receptor levels. Alcohol. Clin. Exp. Res. 20, 961-966.
177. Guizzetti, M. and Costa, L. G. (1996) Inhibition of muscarinic receptor-stimulated glial cell proliferation by ethanol. J. Neurochem. 67, 2236-2245.
178. Guizzetti, M., Catlin, M., and Costa, L. G. (1997) Effects of ethanol on glial cell proliferation: Relevance to the fetal alcohol syndrome. Front. Biosci. 2, e93-98.