Central effects of acamprosate: Part 2. Acamprosate modifies the brain in-vivo proton magnetic resonance spectrum in healthy young male volunteers

Psychiatry Research - Neuroimaging

Volumn 82, Issue 2, 1998, Pages 115-127

  Bolo, Nicolas ^a   Nédélec, Jean François ^a   Muzet, Muriel ^a   De Witte, Philippe ^b   Dahchour, Abdelkader ^b   Durbin, Philippe ^c   MacHer, Jean Paul ^a  

^a FORENAP   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c Lipha   (France)

Author keywords

Acamprosate; Alcoholism; Central nervous system; Glutamate; N acetylaspartate; Proton magnetic resonance spectroscopy

Indexed keywords

ACAMPROSATE; GLUTAMIC ACID; N ACETYLASPARTIC ACID; PLACEBO;

ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; WHITE MATTER;

ADULT; ALCOHOL DETERRENTS; ASPARTIC ACID; BRAIN; CREATINE; CROSS-OVER STUDIES; DIPEPTIDES; DOUBLE-BLIND METHOD; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHOSPHOCREATINE; TAURINE;

EID: 0032550733     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4927(98)00017-1     Document Type: Article

References (26)

1. Abt K. Descriptive data analysis: a concept between confirmatory and exploratory data analysis. Methods of Information in Medicine. 26:1987;77-88.
2. Ballenger J.C., Post R.M. Kindling as a model for alcohol withdrawal syndrome. British Journal of Psychiatry. 133:1978;1-14.
3. 1H-NMR spectroscopic studies of brain. Neuroscience and Biobehavioral Reviews. 13:1989;23-31.
4. Dahchour A., Quertemont E., de Witte P. Acute ethanol increases taurine, but neither GABA nor glutamate in the nucleus accumbens: a microdialysis study in the male rat. Pfluger's Archives: European Journal of Physiology. 427:1994;3-4.
5. Daoust M., Legrand E., Gewiss M., Heidbreder C., De Witte P., Tran G., Durbin P. Acamprosate modulates synaptosomal GABA transmission in chronically alcoholized rats. Pharmacology, Biochemistry and Behavior. 41:1992;669-674.
6. de Witte, P., 1994. In Acamprosate Gastro-Resistant Tablets, Expert report on the Pharmaco-Toxicological Documentation.
7. Gadian D.G. N-acetylaspartate and epilepsy. Magnetic Resonance Imaging. 13(8):1995;1193-1195.
8. Grant K., Lovinger D.M. Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clinical Neuroscience. 3:1995;155-164.
9. Jagannathan N.R., Desai N.G., Raghunathan P. Brain metabolite changes in alcoholism: an in vivo proton magnetic resonance spectroscopy (MRS) study. Magnetic Resonance Imaging. 14(5):1996;553-557.
10. Kimmich R., Hoepfel D. Volume selective multipulse spin-echo spectroscopy. Journal of Magnetic Resonance. 72:1987;379-384.
11. Kwo-On-Yuen P., Newmark R., Jagust W., Bolo N. Reduced N-acetyl-L-aspartic acid in Alzheimer's disease. Neurology Supplement. 1:1991;116-117.
12. Lhuintre J.P., Daoust M., Moore N.D., Chrétien P., Saligaut C., Tran G., Boismare F., Hillemand B. Ability of calcium di-acetylhomotaurine, a GABA agonist, to prevent relapse in weaned alcoholics. Lancet. 1:1985;1014-1016.
13. Lipha, 1994. Acamprosate: Investigator's Brochure, 2nd ed., Lyon, France.
14. Littleton J. Acamprosate in alcohol dependence: how does it work? Addiction. 90:1995;1179-1188.
15. Madamba S.G., Schweitzer P., Zieglgänsberger W., Siggins R. Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro. Alcoholism: Clinical Experimental Research. 20(4):1996;651-658.
16. Michaelis T., Merboldt K.-D., Bruhn H., Hänicke W., Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology. 187:1993;219-227.
17. Paille F.M., Guelfi J.D., Perkins A.C., Royer R.J., Stéru L., Parot P. Double blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol and Alcoholism. 30(2):1995;239-247.
18. Paille, F.M., Parot, P., Gillet, C., 1996. Contribution of acamprosate in maintaining abstinence in weaned alcohol dependent patients. Additional results of the second French multicenter study. In: Soyka, M. (Ed.), Acamprosate in Relapse Prevention in Alcoholism, Springer Verlag, Berlin.
19. Pelc, I., Le Bon, O., Verbanck, P., Lehert, P., Opsomer, L., 1992. Ca-acetyl-homotaurinate for maintaining abstinence in weaned alcoholic patients: a placebo-controlled double blind multicenter study. In: Naranjo, C.A., Sellers, E.M. (Eds.), Novel Pharmacological Interventions for Alcoholism, Springer-Verlag, New York, pp. 348-352.
20. Provencher S. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine. 30(6):1993;672-679.
21. SAS/STAT, 1989. User's Guide, Version 6, 4th ed., Vol. 1 and 2, SAS Institute, Cary, NC, USA.
22. Sass H., Soyka M., Mann K., Zieglgansberger W. Relapse prevention by acamprosate. Archives of General Psychiatry. 53:1996;673-680.
23. Spanagel R., Putzke J., Stefferl A., Schöbitz B., Ziegelgänsberger W. Acamprosate and alcohol: II. Effects on alcohol withdrawal in the rat. European Journal of Pharmacology. 305:1996;45-50.
24. Taylor D.L., Davies S.E., Obrenovitch T.P., Doheny M.H., Patsalos P.N., Clark J.B., Symon L. Investigation into the role of N-acetylaspartate in cerebral osmoregulation. Journal of Neurochemistry. 65:1995;275-281.
25. Tsai G., Gastfriend D.R., Coyle J.T. The glutamatergic basis of human alcoholism. American Journal of Psychiatry. 152(3):1995;332-340.
26. Whitworth A.B., Fischer F., Lesch O.M., Nimmerrichter A., Oberbauer H., Platz T., Potgieter A., Walter H., Fleischhacker W.W. Comparison of acamprosate and placebo in long term treatment of alcohol dependence. Lancet. 347:1996;1438-1442.