Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis

Experimental Neurology

Volumn 167, Issue 2, 2001, Pages 366-375

  Movsesyan, V A ^a   Yakovlev, A G ^a   Fan, L ^a   Faden, A I ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Brain trauma; Neuronal death; Serine protease; TPCK

Indexed keywords

3,4 DICHLOROISOCOUMARIN; DIMETHYL SULFOXIDE; ETOPOSIDE; NEUROPROTECTIVE AGENT; SERINE PROTEINASE INHIBITOR; STAUROSPORINE; TOSYLLYSYL CHLOROMETHYL KETONE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INJURY; CELL VIABILITY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GRANULE CELL; HUMAN; HUMAN CELL; MALE; MOTOR DYSFUNCTION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; RAT; SPATIAL ORIENTATION;

EID: 0035130443     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7567     Document Type: Article

References (31)

1. The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system
2. Serine protease inhibitors: Novel therapeutic targets for stroke?
3. Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes
4. Involvement of both caspase-like proteases and serine proteases in apoptotic cell death induced by ricin, modeccin, diphtheria toxin, and pseudomonas toxin
5. Protection from tumor necrosis factor cytotoxicity by protease inhibitors
6. Protective effect of apoptosis-inhibitory agent, N-tosyl-L-phenylalanyl chloromethyl ketone against ischemia-induced hippocampal neuronal damage
7. Caspase inhibition reduces posttraumatic neuronal cell loss in vitro and improves motor and cognitive outcome after traumatic brain injury
8. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
9. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
10. Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model
11. Neuroprotective effects of 619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury
12. Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury
13. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury
14. Comparison of single and combination drug treatment strategies in experimental brain trauma
15. Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse
16. Developments of a water-maze procedure for studying spatial learning in the rat
17. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
18. The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells
19. Mechanical injury to neuronal/glial cultures in microplates: Role of NMDA receptors and pH in secondary neuronal cell death
20. Staurosporine-induced neuronal apoptosis
21. Etoposide induces programmed death in neurons cultured from the fetal rat central nervous system
22. Thapsigargin induces apoptosis in SH-SY5Y neuroblastoma cells and cerebrocortical cultures
23. Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists
24. Oxidative stress aspects of the cytotoxicity of carbamide peroxide: In vitro studies
25. A new Alamar blue viability assay to rapidly quantify oligodendrocyte death
26. 2+-dependent cleavage of DNA into oligonucleosomal and high molecular mass fragments
27. Serum deprivation and protein synthesis inhibition induce two different apoptotic processes in N18 neuroblastoma cells
28. Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis
29. Serine proteases in rodent hippocampus
30. Proteolysis in rat hypothalamic neurosecretory granules: Characterization of an alpha-chymotrypsin-like activity in the pathway of intracellular processing of prohormones
31. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat