In vivo serotonin 5HT2A receptor binding and personality traits in healthy subjects: A positron emission tomography study

NeuroImage

Volumn 17, Issue 3, 2002, Pages 1470-1478

  Moresco, F M ^a   Dieci, M ^b,c   Vita, A ^b,c   Messa, C ^a   Gobbo, C ^a   Galli, L ^a   Rizzo, G ^a   Panzacchi, A ^a   De Peri, L ^c   Invernizzi, G ^c   Fazio, F ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 FLUOROETHYL)SPIPERONE F 18; SEROTONIN 2A RECEPTOR;

ADULT; ARTICLE; BASAL GANGLION; BEHAVIOR; CONTROLLED STUDY; CORRELATION ANALYSIS; DEVICE; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PARIETAL LOBE; PERSONALITY; POSITRON EMISSION TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; RECEPTOR BINDING; REWARD; SEROTONINERGIC SYSTEM;

EID: 0036432115     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1006/nimg.2002.1239     Document Type: Article

References (67)

1. Ampollini, P., Marchesi, C., Signifredi, R., Ghinaglia, E., Scardovi, F., Codeluppi, S., and Maggini, C. 1999. Temperament and personality features in patients with major depression, panic disorder and mixed conditions. J. Affect. Disord. 52: 203-207.
2. Ball, S., Smolin, J., and Shekhar, A. 2002. A psychobiological approach to personality: Examination within anxious outpatients. J. Psychiatr. Res. 36: 97-103.
3. Barnes, N. M., and Sharp, T. 1999. A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152.
4. 18F]Fluoroethyl)spiperone: In vivo biochemical and kinetic characterization in rodents, nonhuman primates, and humans. J. Cereb. Blood Flow Metab. 9: 830-839.
5. Brandstrom, S., Richter, J., and Przybeck, T. 2001. Distributions by age and sex of the dimensions of temperament and character inventory in a cross-cultural perspective among Sweden, Germany, and the USA. Psychol. Rep. 89: 747-758.
6. Breier, A., Kestler, L., Adler, C., Elman, I., Wiesenfeld, N., Malhotra, A., and Pickar, D. 1998. Dopamine D2 receptor density and personal detachment in healthy subjects. Am. J. Psychiatry 155: 1440-1442.
7. Brown, S. L., Svrakic, D. M., Przybeck, T. R., and Cloninger, C. R. 1992. The relationship of personality to mood and anxiety states: A dimensional approach. J. Psychiatr. Res. 26: 197-211.
8. Burnet, P. W., Mead, A., Eastwood, S. L., Lacey, K., Harrison, P. J., and Sharp, T. 1995. Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. NeuroReport 6: 901-904.
9. 3H]N-n-propylnorapomorphine. Brain Res. 375: 135-149.
10. 3H]spiperone binding: Evidence for accumulation in corpus striatum by agonist-mediated receptor internalization. J. Cereb. Blood Flow Metab. 8: 291-303.
11. Cloninger, C. R. 1987. A systematic method for clinical description and classification of personality variants. Arch. Gen. Psychiatry 44: 573-588.
12. Cloninger, C. R., Przybeck, T. R., and Svrakic, D. M. 1991. The Tridimensional Personality Questionnaire: U.S. normative data. Psychol. Rep. 69: 1047-1057.
13. Cloninger, C. R., Svrakic, D. M., and Przybeck, T. R. 1993. A psychobiological model of temperament and character. Arch. Gen. Psychiatry 50: 975-990.
14. 18F]fluoroethyl)spiperone in baboon brain. Eur. J. Nucl. Med. 14: 80-87.
15. Curtin, F., Walker, J. P., Peyrin, L., Soulier, V., Badan, M., and Schulz, P. 1997. Reward dependence is positively related to urinary monoamines in normal men. Biol. Psychiatry 42: 275-281.
16. Depue, R. A., and Collins, P. F. 1999. Neurobiology of the structure of personality: Dopamine facilitation of incentive motivation, and extraversion. Behav. Brain Res. Sci. 22: 491-517.
17. Di Piero, V., Bruti, G., Venturi, P., Talamonti, F., Biondi, M., Di Legge, S., and Lenzi, G. L. 2001. Aminergic tone correlates of migraine and tension-type headache: A study using the tridimensional personality questionnaire. Headache 41: 63-71.
18. Eaves, L., Heath, A., Martin, N., Maes, H., Neale, M., Kendler, K., Kirk, K., and Corey, L. 1999. Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Res. 2: 62-80.
19. Ebstein, R. P., Nemanov, L., Klotz, I., Gritsenko, I., and Belmaker, R. H. 1997. Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking. Mol. Psychiatry 2: 472-477.
20. Farde, L., Gustavsson, J. P., and Jonsson, E. 1997. D2 dopamine receptors and personality traits. Nature 385: 590.
21. Fazio, F., Messa, C., Moresco, R. M., Colombo, C., Zanardi, R., Prato, K., Gobbo, C., Galli, L., and Smeraldi, E. 1998. Dopaminergic and serotoninergic activity in drug-naive depressed patients assessed with PET and [F18]FESP. J. Nucl. Med. 39: 40.
22. Friston, K., Worsley, K., Frackowiak, R., Mazziotta, J., and Evans, A. 1994. Assessing the significance of focal activations using their spatial extent. HBM 1: 214-220.
23. Friston, K. J., Frith, C. D., Liddle, P. F., and Frackowiak, R. S. 1991. Comparing functional (PET) images: The assessment of significant change. J. Cereb. Blood Flow Metab. 11: 690-699.
24. Friston, K. J., Frith, C. D., Liddle, P. F., and Frackowiak, R. S. 1993. Functional connectivity: The principal-component analysis of large (PET) data sets. J. Cereb. Blood Flow Metab. 13: 5-14.
25. Gerra, G., Zaimovic, A., Timpano, M., Zambelli, U., Delsignore, R., and Brambilla, F. 2000. Neuroendocrine correlates of temperamental traits in humans. Psychoneuroendocrinology 25: 479-496.
26. Gifford, A. N., Gatley, S. J., and Volkow, N. D. 1998. Evaluation of the importance of rebinding to receptors in slowing the approach to equilibrium of high-affinity PET and SPECT radiotracers. Synapse 28: 167-175.
27. Goffinet, A. M., Leysen, J., and Labar, D. 1990. In vitro pharmacological profile of 3-N-(2-fluoroethyl)spiperone. J. Cereb. Blood Flow Metab. 10: 140-142.
28. Goodwin, G. M., Green, A. R., and Johnson, P. 1984. 5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice. Br. J. Pharmacol. 83: 235-242.
29. Gray, J. 1987. The neuropsychology of emotion and personality. In Cognitive Neurochemistry (S. M. Stahl, S. Iverson, and E. Goodman, Eds.), pp. 171-190. Oxford Univ. Press, Oxford.
30. 125I]epidepride. Synapse 23: 115-123.
31. Hansenne, M., Reggers, J., Pinto, E., Kjiri, K., Ajamier, A., and Ansseau, M. 1999. Temperament and character inventory (TCI) and depression. J. Psychiatr. Res. 33: 31-36.
32. Heath, A. C., Cloninger, C. R., and Martin, N. G. 1994. Testing a model for the genetic structure of personality: A comparison of the personality systems of Cloninger and Eysenck. J. Pers. Soc. Psychol. 66: 762-775.
33. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., and Lesch, K. P. 1996. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66: 2621-2624.
34. Hrdina, P. D., and Vu, T. B. 1993. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: An autoradiographic study. Synapse 14: 324-331.
35. Hyttel, J., Overo, K. F., and Arnt, J. 1984. Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram. Psychopharmacology 83: 20-27.
36. Jovkar, S., Wienhard, K., Coenen, H. H., Pawlik, G., and Heiss, W. D. 1991. Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-F18)fluoroethylspiperone and positron emission tomography. Eur. J. Nucl. Med. 18: 158-163.
37. Katsuragi, S., Kunugi, H., Sano, A., Tsutsumi, T., Isogawa, K., Nanko, S., and Akiyoshi, J. 1999. Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol. Psychiatry 45: 368-370.
38. Klimek, V., Zak-Knapik, J., and Mackowiak, M. 1994. Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. J. Psychiatry Neurosci. 19: 63-67.
39. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., and Murphy, D. L. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
40. Loehlin, J. C. 1989. Partitioning environmental and genetic contributions to behavioral development. Am. Psychol. 44: 1285-1292.
41. Manfredonia, M. G., Gasperini, M., Sciuto, G., Bellodi, L., and Smeraldi, E. 1991. The distribution of dimensional personality traits in an Italian general population. New Trends Exp. Clin. Psychiatry 7: 113-129.
42. Mazzanti, C. M., Lappalainen, J., Long, J. C., Bengel, D., Naukkarinen, H., Eggert, M., Virkkunen, M., Linnoila, M., and Goldman, D. 1998. Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch. Gen. Psychiatry 55: 936-940.
43. Moresco, R. M., Colombo, C., Fazio, F., Bonfanti, A., Lucignani, G., Messa, C., Gobbo, C., Galli, L., Del Sole, A., Lucca, A., and Smeraldi, E. 2000. Effects of fluvoxamine treatment on the in vivo binding of [F-18]FESP in drug naive depressed patients: A PET study. NeuroImage 12: 452-465.
44. Nelson, E. C., Cloninger, C. R., Przybeck, T. R., and Csernansky, J. G. 1996. Platelet serotonergic markers and Tridimensional Personality Questionnaire measures in a clinical sample. Biol. Psychiatry 40: 271-278.
45. Newman, J. R., Ewing, S. E., McColl, R. D., Borus, J. S., Nierenberg, A. A., Pava, J., and Fava, M. 2000. Tridimensional Personality Questionnaire and treatment response in major depressive disorder: A negative study. J. Affect. Disord. 57: 241-247.
46. Pazos, A., Probst, A., and Palacios, J. M. 1987. Serotonin receptors in the human brain. IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience 21: 123-139.
47. Peirson, A. R., Heuchert, J. W., Thomala, L., Berk, M., Plein, H., and Cloninger, C. R. 1999. Relationship between serotonin and the temperament and character inventory. Psychiatry Res. 89: 29-37.
48. Peroutka, S. J., and Snyder, S. H. 1980. Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science 210: 88-90.
49. Pietrzyk, U., Herholz, K., Fink, G., Jacobs, A., Mielke, R., Slansky, I., Wurker, M., and Heiss, W. D. 1994. An interactive technique for three-dimensional image registration: Validation for PET, SPECT, MRI and CT brain studies. J. Nucl. Med. 35: 2011-2018.
50. Plomin, R., Owen, M. J., and McGuffin, P. 1994. The genetic basis of complex human behaviors. Science 264: 1733-1739.
51. Quik, M., and Azmitia, E. 1983. Selective destruction of the serotonergic fibers of the fornix-fimbria and cingulum bundle increases 5-HT1 but not 5-HT2 receptors in rat midbrain. Eur. J. Pharmacol. 90: 377-384.
52. Ricketts, M. H., Hamer, R. M., Sage, J. I., Manowitz, P., Feng, F., and Menza, M. A. 1998. Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population. Psychiatr. Genet. 8: 41-44.
53. 18F]fluoroethyl)spiperone, a new dopamine receptor-binding tracer for positron emission tomography. Int. J. Radiat. Appl. Instrum. B 13: 617-624.
54. Schalling, D., Asberg, M., Edman, G., and Oreland, L. 1987. Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity. Acta Psychiatr. Scand. 76: 172-182.
55. Siever, L. J., and Davis, K. L. 1991. A psychobiological perspective on the personality disorders. Am. J. Psychiatry 148: 1647-1658.
56. Stockmeier, C. A., and Kellar, K. J. 1986. In vivo regulation of the serotonin-2 receptor in rat brain. Life Sci. 38: 117-127.
57. Suhara, T., Yasuno, F., Sudo, Y., Yamamoto, M., Inoue, M., Okubo, Y., and Suzuki, K. 2001. Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking. NeuroImage 13: 891-895.
58. Talairach, J., and Tournoux, P. 1988. A Co-planar Stereotactic Atlas of the Human Brain. Stuttgart.
59. Tellegen, A., Lykken, D. T., Bouchard, T. J., Jr., Wilcox, K. J., Segal, N. L., and Rich, S. 1988. Personality similarity in twins reared apart and together. J. Pers. Soc. Psychol. 54: 1031-1039.
60. Turkington, T., and Re, C. 1994. An evaluation of post-injection transmission measurement of PET. IEEE Trans. Nucl. Sci. 41: 1538-1544.
61. Wamsley, J. K., Byerley, W. F., McCabe, R. T., McConnell, E. J., Dawson, T. M., and Grosser, B. I. 1987. Receptor alterations associated with serotonergic agents: An autoradiographic analysis. J. Clin. Psychiatry 48(Suppl.): 9-25.
62. Wienhard, K. 1991. Modelization: Application to the D2 receptors. In Brain Dopaminergic Systems: Imaging with Positron Tomography (J. Baron, D. Comar, L. Farde, J. Martinot, and B. Mazoyer, Eds.), pp. 85-95. Kluwer Academic, Dordrecht/Norwell, MA.
63. 18F]fluoroethylspiperone: Findings in disorders related to the dopaminergic system. J. Neural Transm. Gen. Sect. 81: 195-213.
64. Worsley, K. J., Evans, A. C., Marrett, S., and Neelin, P. 1992. A three-dimensional statistical analysis for CBF activation studies in human brain [see comments]. J. Cereb. Blood Flow Metab. 12: 900-918.
65. Yatham, L. N., Liddle, P. F., Shiah, I. S., Lam, R. W., Adam, M. J., Zis, A. P., and Ruth, T. J. 2001. Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: A PET study. Br. J. Psychiatry 178: 448-453.
66. Yatham, L. N., Liddle, P. F., Shiah, I. S., Scarrow, G., Lam, R. W., Adam, M. J., Zis, A. P., and Ruth, T. J. 2000. Brain serotonin 2 receptors in major depression: A positron emission tomography study. Arch. Gen. Psychiatry 57: 850-858.
67. Zanardi, R., Artigas, F., Moresco, R., Colombo, C., Messa, C., Gobbo, C., Smeraldi, E., and Fazio, F. 2001. Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: A positron emission tomography scan study. J. Clin. Psychopharmacol. 21: 53-58.