The role of Vav proteins in B cell responses

Advances in Experimental Medicine and Biology

Volumn 512, Issue , 2002, Pages 29-34

  Turner, Martin ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VAV PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; EFFECTOR CELL; GERMINAL CENTER; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SECRETORY GRANULE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0036430337     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0757-4_4     Document Type: Article

References (34)

1. Acuto, O. & Cantrell, D. A. T cell activation and the cytoskeleton. Ann. Rev. Immunol. 18, 165-184 (2000).
2. Dustin, M. L. & Cooper, J. A. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling. Nat. Immunol. 1, 23-29 (2000).
3. Henning, S. W. & Cantrell, D. A. GTPases in antigen receptor signalling. Curr. Opin. Immunol. 10, 322-329 (1998).
4. Van Aelst, L. & D'Souza-Schorey, C. Rho GTPases and signalling networks. Gen. Dev. 11, 2295-2322 (1997).
5. Bishop, A. B. & Hall, A. Rho GTPases and their effector proteins. Biochem. J. 348, 241-255 (2000).
6. Bustelo, X. R. Regulatory and signalling properties of the Vav family. Mol. Cell. Biol. 20, 1461-1477 (2000).
7. Turner, M. et al. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7, 451-460 (1997).
8. Kong, Y. Y. et al. Vav regulates peptide-specific apoptosis in thymocytes. J. Exp. Med. 188, 2099-2111 (1998).
9. Fischer, K. D. et al. Vav is a regulator of cytoskeletal reorganisation mediated by the T-cell receptor. Curr. Biol. 8, 554-562 (1998).
10. Holsinger, L. J. et al. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8, 563-572 (1998).
11. Costello, P. S. et al. The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. Proc. Natl. Acad. Sci. U.S.A. 96, 3035-3040 (1999).
12. Tarakhovsky, A. et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467-470 (1995).
13. Zhang, R., Alt, F. W., Davidson, L., Orkin, S. H. & Swat, W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374, 470-473 (1995).
14. Gulbranson-Judge, A. et al. Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help. Eur. J. Immunol. 29, 477-487 (1999).
15. Bachmann, M. F. et al. The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. J. Immunol. 163, 137-142 (1999).
16. Billadeau, D. D., Mackie, S. M., Schoon, R. A. & Leibson, P. J. The Rho family guanine nucleotide excahnge factor Vav-2 regulates the development of cell-mediated cytotoxicity. J. Exp. Med. 192, 381-391 (2000).
17. Moores, S. L. et al. Vav family proteins couple to diverse cell surface receptors. Mol. Cell. Biol. 20, 6364-6373 (2000).
18. Doody, G. M. et al. Vav-2 controls NFAT-dependent transcription in B-but not T-lymphocytes. EMBO. J. 19, 6173-6184 (2000).
19. Doody, G. M. et al. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat. Immunol., 542-547 (2001).
20. Soisson, S. M., Nimnual, A. S., Uy, M., Bar-Sagi D. & Kuriyan, J. Crystal structure of the Dbl and pleckstrin homology domains from the human son of sevenless protein. Cell 95, 259-268 (1998).
21. Guinamard, R., Okigaki, M., Schlessinger, J. & Ravetch, J. V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat. Immunol. 1, 31-36 (2000).
22. Sato, S., Steeber, D. A., Jansen, P. J. & Tedder, T. F. CD19 expression levels regulate B lymphocyte development: Human CD19 restores normal function in mice lacking endogenous CD19. J. Immunol. 158, 4662-4669 (1997).
23. Gardby, E. & Lycke, N. Y. CD19-deficient mice exhibit poor responsiveness to oral immunisation despite evidence of unaltered total IgA levels, germinal centre and IgA-isotype switching in peyer's patches. Eur. J. Immunol. 30, 1861-1871 (2000).
24. Krawczyk, C. et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 13, 463-473 (2000).
25. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. & Hayakama, K. Resolution and characterisation of Pro-B and Pre-Pre-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225 (1991).
26. hi and exhibit unique signaling characteristics. J. Immunol. 149, 2533-2540 (1992).
27. (hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 151, 4431-4444 (1993).
28. Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190, 75-89 (1999).
29. Meffre, E., Casellas, R. & Nussenzweig, M. C. Antibody regulation of B cell development. Nat. Immunol. 1, 379-385 (2000).
30. Lam, K. P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface Ig on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997).
31. Bijsterbosch, M. K., Meade, C. J., Turner, G. A. & Klaus, G. G. B. B lymphocyte receptors and polyphosphoinositide degradation. Cell 41, 999-1006 (1985).
32. Healy, J. I. & Goodnow, C. C. Positive versus negative signaling by lymphocyte antigen receptors. Ann. Rev. Immunol. 16, 645-670 (1998).
33. Satterthwaite, A. B., Li, Z. & Witte, O. N. Btk function in B cell development and response. Semin. Immunol. 10, 309-316 (1998).
34. Fruman, D. A., Satterthwaite, A. B. & Witte, O. N. Xid-like Phenotypes: A B cell signalosome takes shape. Immunity 13, 1-3 (2000).