Transforming growth factor β1 prevents cytokine-mediated inhibitory effects and induction of nitric oxide synthase in the RINm5F insulin-containing β-cell line

Journal of Endocrinology

Volumn 155, Issue 3, 1997, Pages 567-575

  Mabley, J G ^a   Cunningham, J M ^a,b   John, N ^a   Di Matteo, M A ^a   Green, I C ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GAMMA INTERFERON; GLYCERALDEHYDE; INSULIN; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; B LYMPHOCYTE; CELL VIABILITY; CONTROLLED STUDY; ENZYME REGULATION; GROWTH REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0030732192     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1550567     Document Type: Article

References (57)

1. Adcock IM, Brown CR & Barnes PJ 1994 Oxidative stress induces NFκB DNA binding and inducible NOS mRNA in human epithelial cells. Biochemical and Biophysical Research Communications 199 1518-1524.
2. Arsura M, Wu M & Sonenshein GE 1996 TGFβ1 inhibits NF-κB/Rel activity inducing apoptosis of B cells: transcriptional activation of Iκβα. Immunity 5 31-40.
3. Bedoya FJ, Flodström M & Eizirik DL 1995 Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not Superoxide dismutase mRNA, in insulin producing cells. Biochemical and Biophysical Research Communications 210 816-822.
4. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 248-254
5. Carel J-C, Schreiber RD, Falqui L & Lacy PE 1990 Transforming growth factor β decreases the immunogenicity of rat islet xenografts (rat to mouse) and prevents rejection in association with treatment of the recipient with a monoclonal antibody to interferon-gamma. Proceedings of the National Academy of Sciences of the USA 87 1591-1595.
6. Cetkovic-Cvrlje M & Eizirik DL 1994 TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6 399-406.
7. Cetkovic-Cvrlje M, Sandler S & Eizirik DL 1993 Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase. Endocrinology 133 1739-1743.
8. Corbett JA, Lancaster JRJ, Sweetland MA & McDaniel ML 1991 Interleukin-1β-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Journal of Biological Chemistry 266 21351-21354.
9. Corbett JA, Sweetland MA, Wang JL, Lancaster JR & McDaniel ML 1993 Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proceedings of the National Academy of Sciences of the USA 90 1731-1735.
10. Corbett JA, Kwon G, Misko TP, Rodi CP & McDaniel ML 1994 Tyrosine kinase involvement in IL-β-induced expression of iNOS by β-cells purified from islets of Langerhans. American fournal of Physiology 267 C48-C54.
11. Corbett JA, Kwon G, Marino MH, Rodi CP, Sullivan PM, Turk J & McDaniel ML 1996 Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets. American Journal of Physiology 270 C1581-C1587.
12. Corraliza IM, Soler G, Eichmann K & Modolell M 1995 Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages. Biochemical and Biophysical Research Communications 206 667-673.
13. Cunningham JM, Mabley JG & Green IC 1997 Interleukin-1β-mediated inhibition of arginase in RINm5F cells. Cytokine 9 570-576.
14. Devlin J, Palmer RMJ, Gonde CE, O'Grady J, Heaton N, Tan KC, Martin JF, Moncada S & Williams R 1994 Nitric oxide generation a predictive parameter of acute allograft rejection. Transplantation 58 592-595.
15. Di Matteo MA & Green IC 1995 Is β-cell function differentially sensitive to reactive oxygen and nitric oxide. Diabetologia 38 (Suppl 1) A81.
16. Di Matteo MA, Loweth AC, Thomas S, Mabley JG, Morgan NG, Thorpe JR & Green IC 1997 Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin-secreting cell lines but dictate cell death by different mechanisms. Apoptosis 2 164-177.
17. Ding, A, Nathan CF, Graycar J, Derynck R, Stuehr DJ & Srimal S 1990 Macrophage deactivating factor and transforming growth factors-β1, -β2 and -β3 inhibit induction of macrophage nitrogen oxide synthesis by interferon-gamma. Journal of Immunology 145 940-944.
18. Dubois CM, Ruscetti FW, Palaszynski EW, Falk LA, Oppenheim JJ & Keller JR 1990 Transforming growth factor β is a potent inhibitor of interleukin-1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action. Journal of Experimental Medicine 172 737-744.
19. Dunger A, Schlosser M, Ziegler B & Schmidt S 1995 Interleukin-1 beta induces apoptosis in insulin-producing cells. Diabetologia 38 (Suppl 1) A38.
20. Dunger AM, Cunningham J, Delaney CA, Lowe JE, Green MHL, Bone AJ & Green IC 1996 Nitric oxide induced by tumour necrosis factor-alpha and interferon-gamma inhibits insulin secretion and causes DNA damage in unweaned rat islets. Diabetes 45 183-189.
21. Eizirik DL, Sandler S, Welsh N, Cetkovic-Cvrlje M, Nieman A, Geller DA, Pipeleers DG, Bendtzen K & Hellerström C 1994 Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. Journal of Clinical Investigation 93 1968-1974.
22. Flodström M, Welsh N & Eizirik DL 1996 Cytokines activate the nuclear factor KB (NFκB) and induce nitric oxide production in human pancreatic islets. FEBS Letters 385 4-6.
23. Gazdar AF, Chick WL, Oie HK, Sims HL, King DL, Weir GC & Lauris V 1980 Continuous, clonal insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. Proceedings of the National Academy of Sciences of the USA 77 3519-3523.
24. Gey GO & Gey MH 1936 Maintenance of human normal cells and tumour cells in continuous culture. American Journal of Cancer 27 45-76.
25. Gilbert RS & Herschman HR 1993 Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types. Biochemical and Biophysical Research Communications 195 380-384.
26. Gill RG 1991 Transforming growth factor β prevents islet allograft rejection. Transplantation Proceedings 23 747-748.
27. 15N]nitrate in biological fluids. Analytical Biochemistry 126 131-138.
28. Green IC, Cunningham JM, Delaney CA, Elphick MR, Mabley JG & Green MHL 1994 Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production. Biochemical Society Transactions 22 30-37.
29. Gross SS & Wolin MS 1995 Nitric oxide: pathophysiological mechanisms. Annual Review of Physiology 57 737-769.
30. Hao W & Palmer JP 1995 Recombinant human transforming growth factor β does not inhibit the effects of interleukin-1β on pancreatic islet cells. Journal of Interferon and Cytokine Research 15 1075-1081.
31. Harvey AK, Hrubey PS &: Chandrasekhar S 1991 Transforming growth factor-β inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes. Experimental Cell Research 195 376-385.
32. Hecker M, Preiss C, Schini-Kerth VB & Busse R 1996 Antioxidants differentially affect factor κB-mediated nitric oxide synthase expression in vascular smooth muscle cells. FEBS Letters 380 224-228.
33. Hill JR, Corbett JA, Baldwin AC & McDaniel ML 1996 Nitric oxide production by the rat insulinoma cell line, RlNm5F, is specific for IL-1: a spectrophotometric IL-1 bioassay. Analytical Biochemistry 236 14-19.
34. John N, Mabley J & Green I 1996 Cytokine inhibition of protein synthesis in RINm5F cells is nitric oxide mediated and reversed by TGFβ1. Diabetologia 39 (Suppl 1) A103.
35. Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T, Nakamura M, Tatsumi H, Yamasaki Y, Kamada T & Taniguchi N 1995 Apoptotic cell death triggered by nitric oxide in pancreatic B-cells. Diabetes 44 733-738.
36. Karlsen AE, Andersen HU, Vissing H, Mose Larsen P, Fey SJ, Cuartero BG, Madsen OD, Petersen JS, Mortensen SB, Mandrup-Poulsen T, Boel E & Nerup J 1995 Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans. Diabetes 44 753-758.
37. Koevary SB 1991a Effects of transforming growth factor β (TGF-β) on the lymphocyte- and cytokine-mediated destruction of islet cells in the BB/Wor rat. Lymphokine and Cytokine Research 10 337-342.
38. Koevary SB 1991b Effects of incubation of islet cells with transforming growth factor beta (TGF-β) on their susceptibility to diabetic lymphocyte mediated destruction in the rat, in vitro. Diabetes Research 18 123-127.
39. Kröncke K-D, Fehsel K & Kolb-Bachofen V 1995 Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biological Chemistry 376 327-343.
40. Kwon G, Corbett JA, Wang JL & McDaniel ML 1993 IL-1β-induced inhibition of insulin secretion is prevented by dexamethasone and genistein: possible involvement of a tyrosine kinase during IL-1β-induced iNOS expression by islets. Diabetes 42 (Suppl) 130A.
41. Kwon G, Corbett JA, Rodi CP, Sullivan P & McDaniel ML 1995 Interleukin-1β-induced nitric oxide synthase expression by rat pancreatic β-cells: Evidence for the involvement of nuclear factor κB in the signaling mechanism. Endocrinology 136 4790-4795.
42. Loweth A, Martin Z, Scarpello JHB, James RFL, Williams GT & Morgan NG 1996a Differential sensitivity of clonal β-cells and human islets to induction of apoptosis by nitric oxide donors. Diabetic Medicine 13 P40.
43. Loweth AC, Williams GT, Scarpello JHB & Morgan NG 1996b Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic β-cells. Experimental Cell Research 229 69-76.
44. Mabley JG, Cunningham JM, Schulster D & Green IC 1994 Transforming growth factor β1 protects rat islets from the inhibitory effects of interleukin-1 on insulin secretion. Diabetologia 37 (Suppl 1) A44.
45. Mitlianga P, Germanidis G, Moutsopoulos HM & Papadopoulos GK 1995 The effect of transforming growth factor β1, and tumor necrosis factor α on the cytotoxic-cytostatic action of interleukin-1 (α and β isoforms) on the pancreatic B cell line RIN-5AH. International Jonrnal of Immunopathology and Pharmacology 8 67-77.
46. Modolell M, Corraliza IM, Link F, Soler G & Eichmann K 1995 Reciprocal regulation ot the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. European Journal of Immunology 25 1101-1104.
47. Mosmann TJ 1983 Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays. Journal of Immunological Methods 65 55-63.
48. Mühl H, Geiger T, Pignat W, Mörki F, van den Bosch H, Cerletti N, Cox D, McMaster G, Vosbeck K & Pfeilschifter J 1992 Transforming growth factors type-β and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin-1 and forskolin in rat mesangial cells. FEBS Letters 301 190-194.
49. Roberts AB, Vodovotz Y, Roche NS, Sporn MB & Nathan CF 1992 Role of nitric oxide in antagonistic effects of transforming growth factor-β and interleukin-1β on the beating rate of cultured cardiac myocytes. Molecular Endocrinology 6 1921-1930.
50. Sandberg J-O, Eizirik DC, Sandier S, Tracey DE & Andersson A 1993 Treatment with an interleukin-1 receptor antagonist protein prolongs monse islet allograft survival. Diabetes 42 1845-1851.
51. Sjöholm Ä 1991 Cytokines inhibit proliferation and insulin secretion by clonal rat insulinoma cells (RINm5F) non-synergistically and in a pertussis toxin-insensitive manner. Immunology Letters 30 81-86.
52. Southern C, Schulster D & Green IC 1990 Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-alpha by an L-arginine-dependent nitric oxide generating mechanism. FEBS Letters 276 42-44.
53. Suarez-Pinzon WL, Strynadka K, Schulz R & Rabinovitch A 1994 Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide. Endocrinology 134 1006-1010.
54. Turner M, Chantry D, Katsikis P, Berger A, Brennan FM & Feldmann M 1991 Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-β. European Journal of Immunology 21 1635-1639.
55. Vodovotz Y, Bogdan C, Paik J, Xie Q & Nathan C 1993 Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. Journal of Experimental Medicine 178 605-613.
56. Wang WW, Jenkinson CP, Griscavage JM, Kern RM, Arabolos NS, Byrns RE, Cederbaum SD & Ignarro LJ 1995 Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysacchande. Biochemical and Biophysical Research Communication 210 1009-1016.
57. Welsh N, Eizirik DL, Bendtzen K & Sandler S 1991 Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129 3167-3173.