Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-ribosylation factors

Biological Research

Volumn 35, Issue 2, 2002, Pages 247-265

  Hawadle, Muhamed A ^a   Folarin, Najeem ^a   Martin, Rosemary ^a   Jackson, Trevor R ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

ADP ribosylation factor; Centaurin; Cytohesin; GTPase activating protein; Guanine nucleotide exchange factor; Phosphoinositide

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; CENTAURIN; CYTOHESIN 1; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LIPID; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHOLIPASE D; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL FATE; CELL MOTION; CELL TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; ENDOSOME; MACROMOLECULE; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036399003     PISSN: 07169760     EISSN: None     Source Type: Journal    
DOI: 10.4067/S0716-97602002000200017     Document Type: Article

References (78)

1. ANDREEV J, SIMON JP, SABATINI DD, KAM J, PLOWMAN G, RANDAZZO PA, SCHLESSINGER J (1999) Identification of a new Pyk2 target protein with Arf-GAP activity. Mol Cell Biol 19:2338-2350
2. ANTONNY B, HUBER I, PARIS S, CHABRE M, CASSEL D (1997) Activation of ADP-ribosylation factor 1 GTPase-activating protein by phosphatidylcholine-derived diacylglycerols. J Biol Chem 272:30848-30851
3. ARTHUR WT, BURRIDGE K, NOREN NK (2002). Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol Res 35: 239-246
4. ASHERY U, KOCH H, SCHEUSS V, BROSE N, RETTIG J (1999) A presynaptic role for the ADP ribosylation factor (ARF)-specific GDP/GTP exchange factor msec7-1. Proc Natl Acad Sci.USA 96:1094-1099
5. 3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function. Biol Res 35: 231-238
6. BROWN FD, ROZELLE AL, YIN HL, BALLA T, DONALDSON JG (2001) Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J Cell Biol 154:1007-1017
7. BROWN MT, ANDRADE J, RADHAKRISHNA H, DONALDSON JG, COOPER JA, RANDAZZO PA (1998) ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol 18:7038-7051
8. CAPLAN S, NASLAVSKY N, HARTNELL LM, LODGE R, POLISHCHUK RS, DONALDSON JG, BONIFACINO JS (2002) A tubular EHDI-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J 21:2557-2567
9. CAUMONT AS, VITALE N, GENSSE M, GALAS MC, CASANOVA JE, BADER MF (2000) Identification of a plasma membrane-associated guanine nucleotide exchange factor for ARF6 in chromaffin cells. Possible role in the regulated exocytotic pathway. J Biol Chem 275:15637-15644
10. CHARDIN P, PARIS S, ANTONNY B, ROBINEAU S, BERAUD-DUFOUR S, JACKSON CL, CHABRE M (1996) A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature 384:481-484
11. CHAVRIER P, GOUD B (1999) The role of ARF and Rab GTPases in membrane transport. Curr Opin Cell Biol 11:466-475
12. CUKIERMAN E, HUBER I, ROTMAN M, CASSEL D (1995) The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science 270:1999-2002
13. CULLEN PJ, CHARDIN P (2000) Membrane targeting: what a difference a G makes. Curr Biol 10:R876-R878
14. DERRIEN V, COUILLAULT C, FRANCO M, MARTINEAU S, MONTCOURRIER P, HOULGATTE R, CHAVRIER P (2002) A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. J Cell Sci 115:2867-2879
15. DIERKS H, KOLANUS J, KOLANUS W (2001) Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain. J Biol Chem 276:37472-37481
16. DONALDSON JG, JACKSON CL (2000) Regulators and effectors of the ARF GTPases. Curr Opin Cell Biol 12:475-482
17. DONALDSON JG, CASSEL D, KAHN RA, KLAUSNER RD (1992) ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes. Proc Natl. Acad Sci USA 89:6408-6412
18. DUBOIS T, KERAI P, ZEMLICKOVA E, HOWELL S, JACKSON TR, VENKATESWARLU K, CULLEN PJ, THEIBERT AB, LAROSE L, ROACH PJ, AITKEN A (2001) Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. J Biol Chem 276:18757-18764
19. DUBOIS T, HOWELL S, ZEMLICKOVA E, AITKEN A (2002) Identification of casein kinase I alpha interacting protein partners. FEBS Lett 517:167-171
20. FERGUSON KM, KAVRAN JM, SANKARAN VG, FOURNIER E, ISAKOFF SJ, SKOLNIK EY, LEMMON MA (2000) Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell 6:373-384
21. FRANCO M, BORETTO J, ROBINEAU S, MONIER S, GOUD B, CHARDIN P, CHAVRIER P (1998) ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. Proc Natl Acad Sci USA 95:9926-9931
22. FRANCO M, PETERS PJ, BORETTO J, VAN DONSELAAR E, NERI A, D'SOUZA-SCHOREY C, CHAVRIER P (1999) EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. EMBO J 18:1480-1491
23. FRANK S, UPENDER S, HANSEN SH, CASANOVA JE (1998a) ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. J Biol Chem 273:23-27
24. FRANK S, HATFIELD JC, CASANOVA JE (1998b) Remodeling of the actin cytoskeleton is coordinately regulated by protein kinase C and the ADP-ribosylation factor nucleotide exchange factor ARNO. Mol Biol Cell 9:3133-3146
25. FURMAN C, SHORT SM, SUBRAMANIAN RR, ZETTER BR, ROBERTS TM (2002) DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J Biol Chem 277:7962-7969
26. GEIGER C, NAGEL W, BOEHM T, VAN KOOYK Y, FIGDOR CG, KREMMER E, HOGG N, ZEITLMANN L, DIERKS H, WEBER KS, KOLANUS W (2000) Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. EMBO J 19:2525-2536
27. GIANCOTTI FG (2000) Complexity and specificity of integrin signaling. Nat Cell Biol 2:E13-E14
28. GOLDBERG J (1999) Structural and functional analysis of the ARF-1 ARF GAP complex reveals a role for coatomer in GTP hydrolysis. Cell 96: 893-902
29. HAMMONDS-ODIE LP, JACKSON TR, PROFIT AA, BLADER IJ, TURCK CW, PRESTWICH GD, THEIBERT AB (1996) Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain. J Biol Chem 271:18859-18868
30. JACKSON TR, BROWN FD, NIE Z, MIURA K, FORONI L, SUN J, HSU VW, DONALDSON JG, RANDAZZO PA (2000a) ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. J Cell Biol 151:627-638
31. JACKSON TR, KEARNS BG, THEIBERT AB (2000b) Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. Trends Biochem Sci 25:489-495
32. JENSEN RB, LYKKE-ANDERSEN K, FRANDSEN GI, NIELSEN HB, HASELOFF J, JESPERSEN HM, MUNDY J, SKRIVER K (2000) Promiscuous and specific phospholipid binding by domains in ZAC, a membrane-associated Arabidopsis protein with an ARF GAP zinc finger and a C2 domain. Plant Mol Biol 44:799-814
33. KAM JL, MIURA K, JACKSON TR, GRUSCHUS J, ROLLER P, STAUFFER S, CLARK J, ANEJA R, RANDAZZO PA (2000) Phosphoinositide-dependent activation of the ADP-ribosylation factor GTPase-activating protein ASAP1. Evidence for the pleckstrin homology domain functioning as an allosteric site. J Biol Chem 275:9653-9663
34. KING FJ, HU E, HARRIS DF, SARRAF P, SPIEGELMAN BM, ROBERTS TM (1999) DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Mol Cell Biol 19:2330-2337
35. KITANO J, KIMURA K, YAMAZAKI Y, SODA T, SHIGEMOTO R, NAKAJIMA Y, NAKANISHI S (2002) Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J Neurosci 22:1280-1289
36. KLARLUND JK, GUILHERME A, HOLIK JJ, VIRBASIUS JV, CHAWLA A, CZECH MP (1997) Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275:1927-1930
37. KLARLUND JK, RAMEH LE, CANTLEY LC, BUXTON JM, HOLIK JJ, SAKELIS C, PATKI V, CORVERA S, CZECH MP (1998) Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:1859-1862
38. KLARLUND JK, TSIARAS W, HOLIK JJ, CHAWLA A, CZECH MP (2000) Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J Biol Chem 275:32816-32821
39. KLARLUND JK, HOLIK J, CHAWLA A, PARK JG, BUXTON J, CZECH MP (2001) Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. J Biol Chem 276:40065-40070
40. KOLANUS W, NAGEL W, SCHILLER B, ZEITLMANN L, GODAR S, STOCKINGER H, SEED B (1996) Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 86:233-242
41. KOLANUS W, SEED B (1997) Integrins and inside-out signal transduction: converging signals from PKC and PIP3. Curr Opin Cell Biol 9:725-731
42. KONDO A, HASHIMOTO S, YANO H, NAGAYAMA K, MAZAKI Y, SABE H (2000) A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. Mol Biol. Cell 11: 1315-1327
43. KORTHAUER U, NAGEL W, DAVIS EM, LE BEAU MM, MENON RS, MITCHELL EO, KOZAK CA, KOLANUS W, BLUESTONE JA (2000) Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol 164:308-318
44. LEE SY, MANSOUR M, POHAJDAK B (2000) B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex. Exp Cell Res.256:515-521
45. LEE SY, POHAJDAK B (2000) N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi. J Cell Sci 113 (Pt 11):1883-1889
46. LIU Y, LOIJENS JC, MARTIN KH, KARGINOV AV, PARSONS JT (2002) The Association of ASAP1, an ADP Ribosylation Factor-GTPase Activating Protein, with Focal Adhesion Kinase Contributes to the Process of Focal Adhesion Assembly. Mol Biol Cell 13:2147-2156
47. LUPAS A, VAN DYKE M, STOCK J (1991) Predicting coiled coils from protein sequences. Science 252:1162-1164
48. MANSOUR M, LEE SY, POHAJDAK B (2002) The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. J Biol Chem, in press
49. MONIER S, CHARDIN P, ROBINEAU S, GOUD B (1998) Overexpression of the ARF1 exchange factor ARNO inhibits the early secretory pathway and causes the disassembly of the Golgi complex. J Cell Sci III (Pt 22):3427-3436
50. MORGENSTERN B (1999) DIALIGN 2: improvement of the segment-to-segment approach to multiple sequence alignment. Bioinformatics 15:211-218
51. MOSS J, VAUGHAN M. (1995) Structure and function of ARF proteins; activators of cholera toxin and critical components of intracellular vesicular transport processes. J Biol Chem 270, 12327-12330
52. NAGEL W, SCHILCHER P, ZEITLMANN L, KOLANUS W (1998a) The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function. Mol Biol Cell 9:1981-1994
53. NAGEL W, ZEITLMANN L, SCHILCHER P, GEIGER C, KOLANUS J, KOLANUS W (1998b) Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1. J Biol. Chem 273:14853-14861
54. NEVRIVY DJ, PETERSON VJ, AVRAM D, ISHMAEL JE, HANSEN SG, DOWELL P, HRUBY DE, DAWSON MI, LEID M (2000) Interaction of GRASP, a protein encoded by a novel retinoic acid- induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J Biol Chem 275:16827-16836
55. OGASAWARA M, KIM SC, ADAMIK R, TOGAWA A, FERRANS VJ, TAKEDA K, KIRBY M, MOSS J, VAUGHAN M (2000) Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. J Biol Chem 275:3221-3230
56. PAGE RD (1996) TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 12:357-358
57. PASQUALATO S, MENETREY J, FRANCO M, CHERFILS J (2001) The structural GDP/GTP cycle of human Arf6. EMBO Rep 2: 234-238
58. PRESLEY JF, WARD TH, PFEIFER AC, SIGGIA ED, PHAIR RD, LIPPINCOTT-SCHWARTZ J (2002) Dissection of COP1 and Arf1 dynamics in vivo and role in Golgi membrane transport. Nature 417:187-193
59. PUERTOLLANO R, RANDAZZO PA, PRESLEY JF, HARTNELL LM, BONIFACINO JS (2001) The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell 105:93-102
60. RADHAKRISHNA H, DONALDSON JG (1997) ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J Cell Biol 139:49-61
61. RANDAZZO PA, ANDRADE J, MIURA K, BROWN MT, LONG YQ, STAUFFER S, ROLLER P, COOPER JA (2000) The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton. Proc Natl Acad Sci USA 97:4011-4016
62. SANTY LC, CASANOVA JE (2001) Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol 154:599-610
63. SANTY LC, CASANOVA JE (2002) GTPase Signaling: Bridging the GAP between ARF and Rho. Curr Biol 12:R360-R362
64. SANTY LC, FRANK SR, HATFIELD JC, CASANOVA JE (1999) Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch. Curr Biol 9:1173-1176
65. SZAFER E, PICK E, ROTMAN M, ZUCK S, HUBER I, CASSEL D (2000) Role of coatomer and phospholipids in GTPase-activating protein-dependent hydrolysis of GTP by ADP-ribosylation factor-1. J Biol Chem 275:23615-23619
66. SZAFER E, ROTMAN M, CASSEL D (2001) Regulation of GTP hydrolysis on ADP-ribosylation factor-1 at the Golgi membrane. J Biol Chem 276:47834-47839
67. TANAKA K, IMAJOH-OHMI S, SAWADA T, SHIRAI R, HASHIMOTO Y, IWASAKI S, KAIBUCHI K, KANAHO Y, SHIRAI T, TERADA Y, KIMURA K, NAGATA S, FUKUI Y (1997) A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains. Eur J Biochem 245:512-519
68. TANG P, CHENG TP, AGNELLO D, WU CY, HISSONG BD, WATFORD WT, AHN HJ, GALON J, MOSS J, VAUGHAN M, OSHEA JJ, GADINA M (2002) Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. Proc Natl Acad Sci USA 99:2625-2629
69. TANIGAWA G, ORCI L, AMHERDT M, RAVAZZOLA M, HELMS JB, ROTHMAN JE (1993) Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. J Cell Biol 123:1365-1371
70. TEAL SB, HSU VW, PETERS PJ, KLAUSNER RD, DONALDSON JG (1994) An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes. J Biol Chem 269:3135-3138
71. TURNER CE, WEST KA, BROWN MC (2001) Paxillin-ARF GAP signaling and the cytoskeleton. Curr Opin Cell Biol 13:593-599
72. VENKATESWARLU K, OATEY PB, TAVARE JM, JACKSON TR, CULLEN PJ (1999) Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. Biochem J 340 (Pt 2):359-363
73. VITALE N, PATTON WA, MOSS J, VAUGHAN M, LEFKOWITZ RJ, PREMONT RT (2000) GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. J Biol Chem 275:13901-13906
74. WEBER KS, WEBER C, OSTERMANN G, DIERKS H, NAGEL W, KOLANUS W (2001) Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines. Curr Biol 11: 1969-1974
75. WHITLEY P, GIBBARD AM, KOUMANOV F, OLDFIELD S, KILGOUR EE, PRESTWICH GD, HOLMAN GD (2002) Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. Eur J Cell Biol 81:222-230
76. WRIGHT MM, MCMASTER CR. (2002) Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis. Biol Res 35: 223-229
77. YE K, HURT KJ, WU FY, FANG M, LUO HR, HONG JJ, BLACKSHAW S, FERRIS CD, SNYDER SH (2000) Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 103:919-930
78. ZAAL KJ, SMITH CL, POLISHCHUK RS, ALTAN N, COLE NB, ELLENBERG J, HIRSCHBERG K, PRESLEY JF, ROBERTS TH, SIGGIA E, PHAIR RD, LIPPINCOTT-SCHWARTZ J (1999) Golgi membranes are absorbed into and reemerge from the ER during mitosis. Cell 99:589-601