The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function

Molecular Biology of the Cell

Volumn 9, Issue 8, 1998, Pages 1981-1994

  Nagel, Wolfgang ^a   Schilcher, Pierre ^a   Zeitlmann, Lutz ^a   Kolanus, Waldemar ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CELL PROTEIN; CYTOHESIN 1; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PLECKSTRIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL FUNCTION; CELL MEMBRANE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; T LYMPHOCYTE;

EID: 0031828870     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.8.1981     Document Type: Article

References (48)

1. Adamson, P., Paterson, H.F., and Hall, A. (1992). Intracellular localization of the P21rho proteins. J. Cell Biol. 119, 617-627.
2. Cadwallader, K.A., Paterson, H., Macdonald, S.G., and Hancock, J.F. (1994). N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization. Mol. Cell. Biol. 14, 4722-4730.
3. Chardin, P., Paris, S., Antonny, B., Robineau, S., Beraud Dufour, S., Jackson, C.L., and Chabre, M. (1997). A human exchange factor for ARF contains Sec7-and pleckstrin-homology domains. Nature 384, 481-484.
4. Chen, R.-H., Corbalan-Garcia, S., and Bar-Sagi, D. (1997). The role of the PH domain in the signal dependent membrane targeting of Sos. EMBO J. 16, 1351-1359.
5. D'Souza, S.C., and Stahl, P.D. (1995). Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp. Cell. Res. 221, 153-159.
6. Ferguson, K.M., Lemmon, M.A., Schlessinger, J., and Sigler, P.B. (1995). Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell 83, 1037-1046.
7. Franke, T.F., Kaplan, D.R., and Cantley, L.C. (1997a). PI3K: downstream AKTion blocks apoptosis. Cell 88, 435-437.
8. Franke, T.F., Kaplan, D.R., Cantley, L.C., and Toker, A. (1997b). Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665-668.
9. Frech, M., Andjelkovic, M., Ingley, E., Reddy, K.K., Falck, J.R., and Hemmings, B.A. (1997). High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/ protein kinase B and their influence on kinase activity. J. Biol. Chem. 272, 8474-8481.
10. Fukada, M., Kojima, T., Kabayama, H., Mikoshiba, K. (1996). Mutation of the Pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5 tetrakisphosphate binding capacity. J. Biol. Chem. 271, 30303-30306.
11. Garcia, P., Gupta, R., Shah, S., Morris, A.J., Rudge, S.A., Scarlata, S., Petrova, V., McLaughlin, S., and Rebecchi, M.J. (1995). The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry 34, 16228-16234.
12. Ghomashchi, F., Zhang, X., Liu, L., and Gelb, M.H. (1995). Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange. Biochemistry 34, 11910-11918.
13. Hancock, J.F., Cadwallader, K., Paterson, H., and Marshall, C.J. (1991). A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J. 10, 4033-4039.
14. Hancock, J.F., Paterson, H., and Marshall, C.J. (1990). A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63, 133-139.
15. Harlan, J.E., Hajduk, P.J., Yoon, H.S., and Fesik, S.W. (1994). Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371, 168-170.
16. Harlan, J.E., Yoon, H.S., Hajduk, P.J., and Fesik, S.W. (1995). Structural characterization of the interaction between a pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate. Biochemistry 34, 9859-9864.
17. Hyvönen, M., Macias, M.J., Nilges, M., Oschkinat, H., Saraste, M., and Wilmanns, M. (1995). Structure of the binding site for inositol phosphates in a PH domain. EMBO J. 14, 4676-4685.
18. Hyvönen, M., and Saraste, M. (1997). Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J. 16, 3396-3404.
19. Kim, C.G., Park, D., and Rhee, S.G. (1996). The role of carboxyl-terminal basic amino acids in Gqalpha-dependent activation, particulate association, and nuclear localization of phospholipase C-betal. J. Biol. Chem. 271, 21187-21192.
20. Klarlund, J.K., Guilherme, A., Holik, J.J., Virbasius, J.V., Chawla, A., and Czech, M.P. (1997). Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275, 1927-1930.
21. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H., and Seed, B. (1996). Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 86, 233-242.
22. Kreck, M.L., Freeman, J.L., Abo, A., and Lambeth, I.D. (1996). Membrane association of Rac is required for high activity of the respiratory burst oxidase. Biochemistry 35, 15683-15692.
23. Kubiseski, T.J., Chook, Y.M., Parris, W.E., Rozakis, A.M., and Pawson, T. (1997). High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate. J. Biol. Chem. 272, 1799-1804.
24. Kwong, J., and Lublin, D.M. (1995). Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck. Biochem. Biophys. Res. Commun. 207, 868-876.
25. Lemmon, M.A., Falasca, M., Ferguson, K.M., and Schlessinger, J. (1997). Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin homology domains. Trends Cell Biol. 7, 237-242.
26. Lemmon, M.A., Ferguson, K.M., O'Brien, R., Sigler, P.B., and Schlessinger, J. (1995). Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc. Natl. Acad. Sci. USA 92, 10472-10476.
27. Lemmon, M.A., Ferguson, K.M., and Schlessinger, J. (1996). PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85, 621-624.
28. Ma, A.D., Brass, L.F., and Abrams, C.S. (1997). Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain. J. Cell Biol. 136, 1071-1079.
29. Meller, N., Liu, Y.C., Collins, T.L., Bonnefoyberard, N., Baier, G., Isakov, N., and Altman, A.R.A. (1996). Direct interaction between protein kinase c theta (pkc theta) and 14 3 3 tau in t cells: 14 3 3 overexpression results in inhibition of pkc theta translocation and function. Mol. Cell. Biol. 16, 5782-5791.
30. Michiels, F., Stam, J.C., Hordijk, P.L., van der Kammen, R.A., Ruuls, V.S.L., Feltkamp, C.A., and Collard, J.G. (1997). Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation. J. Cell Biol. 137, 387-398.
31. Miki, H., Miura, K., and Takenawa, T. (1996). N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 15, 5326-5335.
32. Mitchell, D.A., Farh, L., Marshall, T.K., and Deschenes, R.J. (1994). A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiae. J. Biol. Chem. 269, 21540-21546.
33. Musacchio, A., Gibson, T., Rice, P., Thompson, J., Saraste, M. (1993). The PH domain: a common piece in structural pathwork of signalling protein. Trends Biochem. Sci. 18, 343-348.
34. Nagel, W., Zeitlmann, L., Schilcher P., Geiger, C., Kolanus, W. (1998). Phosphoinositide 3-OH kinase activates the beta-2 integrin adhesion pathway and induces the recruitment of cytohesin-1. J. Biol. Chem. 273, 14853-14861.
35. Newman, C.M., Giannakouros, T., Hancock, J.F., Fawell, E.H., Armstrong, J., and Magee, A.I. (1992). Post-translational processing of Schizosaccharomyces pombe YPT proteins. J. Biol. Chem. 267, 11329-11336.
36. Patki, V., Virbasius, J., Lane, W.S., Toh, B.H., Shpetner, H.S., and Corvera, S. (1997). Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 94, 7326-7330.
37. Pawson, T. (1995). Protein modules and signalling networks. Nature 373, 573-579.
38. Pitcher, J.A., Touhara, K., Payne, E.S., and Lefkowitz, RJ. (1995). Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J. Biol. Chem. 270, 11707-11710.
39. Romeo, C., and Seed, B. (1991). Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 64, 1037-1046.
40. Salim, K. et al. (1996). Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J. 25, 6241-6250.
41. Shpetner, H., Joly, M., Hartley, D., and Corvera, S. (1996). Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin. J. Cell Biol. 132, 595-605.
42. Soneoka, Y., Kingsman, S.M., and Kingsman, A.J. (1997). Mutagenesis analysis of the murine leukemia virus matrix protein: identification of regions important for membrane localization and intracellular transport. J. Virol. 71, 5549-5559.
43. Touhara, K., Koch, W.J., Hawes, B.E., and Lefkowitz, R.J. (1995). Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. J. Biol. Chem. 270, 17000-17005.
44. Walz, G., Aruffo, A., Kolanus, W., Bevilacqua, M., and Seed, B. (1990). Recognition by ELAM-1 of the sialy1-Lex determinant on myeloid and tumor cells. Science 250, 1132-1135.
45. Wang, D.S., Deng, T., and Shaw, G. (1997). Membrane binding and enzymatic activation of a Db1 homology domain require the neighboring pleckstrin homology domain. Biochem. Biophys. Res. Commun. 234, 183-189.
46. Wang, D.S., Miller, R., Shaw, R., and Shaw, G. (1996). The pleckstrin homology domain of human beta I sigma II spectrin is targeted to the plasma membrane in vivo. Biochem. Biophys. Res. Commun. 225, 420-426.
47. Wang, D.S., and Shaw, G. (1995). The association of the C-terminal region of beta I sigma II spectrin to brain membranes is mediated by a PH domain, does not require membrane proteins, and coincides with a inositol-1,4,5 triphosphate binding site. Biochem. Biophys. Res. Commun. 217, 608-615.
48. Zheng, J., Cahill, S.M., Lemmon, M.A., Fushman, D., Schlessinger,J., and Cowburn, D. (1996). Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity. J. Mol. Biol. 255, 14-21.