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Volumn 216, Issue 3, 2002, Pages 301-326

Exploring the formation of Alzheimer's disease senile plaques in Silico

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

EID: 0036389411     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2002.2540     Document Type: Article
Times cited : (56)

References (89)
  • 1
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • AKIYAMA, H., et al. (The Neuroinflammation working group) (1999). Inflammation and Alzheimer's disease. Neurobiol. Aging. 21, 383-421.
    • (1999) Neurobiol. Aging , vol.21 , pp. 383-421
    • Akiyama, H.1
  • 2
    • 0030038809 scopus 로고    scopus 로고
    • Scavenging of Alzheimer's amyloid beta-protein by microglia in culture
    • ARD, M. D., COLE, G. M., WEI, J., MEHRLE, A. P. & FRATKIN, J. D. (1996). Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J. Neurosci. Res. 43, 190-202.
    • (1996) J. Neurosci. Res. , vol.43 , pp. 190-202
    • Ard, M.D.1    Cole, G.M.2    Wei, J.3    Mehrle, A.P.4    Fratkin, J.D.5
  • 3
    • 0024834504 scopus 로고
    • Evidence for a diffusional model of Alzheimer's amyloid A4 beta amyloid deposition during neurotic plaque formation
    • BENES, F. M., REIFEL, J. L., MAJOCHA, R. E. & MAROTTA, C. A. (1989). Evidence for a diffusional model of Alzheimer's amyloid A4 beta amyloid deposition during neurotic plaque formation. Neuroscience 33, 483-488.
    • (1989) Neuroscience , vol.33 , pp. 483-488
    • Benes, F.M.1    Reifel, J.L.2    Majocha, R.E.3    Marotta, C.A.4
  • 4
    • 0025350125 scopus 로고
    • Heterogeneity in interleukin (IL)-1 receptors expressed on human B cell lines. Differences in the molecular properties of IL-1 alpha and IL-1 beta binding sites
    • BENJAMIN, D., WORMSLEY, S. & DOWER, S. K. (1990). Heterogeneity in interleukin (IL)-1 receptors expressed on human B cell lines. Differences in the molecular properties of IL-1 alpha and IL-1 beta binding sites. J. Biol. Chem. 265, 9943-9951.
    • (1990) J. Biol. Chem. , vol.265 , pp. 9943-9951
    • Benjamin, D.1    Wormsley, S.2    Dower, S.K.3
  • 5
    • 0029010133 scopus 로고
    • Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta, IL-6 and IL-10
    • BENVENISTE, E. N., TANG, L. P. & LAW, R. M. (1995). Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta, IL-6 and IL-10. Int. J. Dev. Neurosci. 13, 341-349.
    • (1995) Int. J. Dev. Neurosci. , vol.13 , pp. 341-349
    • Benveniste, E.N.1    Tang, L.P.2    Law, R.M.3
  • 6
    • 0024150976 scopus 로고    scopus 로고
    • Central nervous system toxicity of interferons and other cytokines
    • BOCCI, V. (1998) Central nervous system toxicity of interferons and other cytokines, J Biol. Regul. Homeost. Agents 2, 107-118.
    • (1998) J. Biol. Regul. Homeost. Agents , vol.2 , pp. 107-118
    • Bocci, V.1
  • 9
  • 10
    • 0027526419 scopus 로고
    • Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
    • CAI, X.-D., GOLDE, T. E. & YOUNKIN, S. G. (1993). Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science (Washington, DC). 259, 514-516.
    • (1993) Science (Washington, DC) , vol.259 , pp. 514-516
    • Cai, X.-D.1    Golde, T.E.2    Younkin, S.G.3
  • 11
    • 0033215124 scopus 로고    scopus 로고
    • Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways
    • CARLSON, N. G., WIEGGEL, W. A., CHEN, J., BACCHI, A., ROGERS, S. W. & GAHRING, L.C. (1999). Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways, J. Immunol. 163, 3963-3968.
    • (1999) J. Immunol. , vol.163 , pp. 3963-3968
    • Carlson, N.G.1    Wieggel, W.A.2    Chen, J.3    Bacchi, A.4    Rogers, S.W.5    Gahring, L.C.6
  • 12
    • 0029620390 scopus 로고
    • Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors
    • CHAO, C. C., HU, S., EHRLICH, L. & PETERSON, P. K. (1995). Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav. Immun. 9, 355-365.
    • (1995) Brain Behav. Immun. , vol.9 , pp. 355-365
    • Chao, C.C.1    Hu, S.2    Ehrlich, L.3    Peterson, P.K.4
  • 13
    • 0028178798 scopus 로고
    • Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
    • CHENG, B., CHRISTAKOS, S. & MATTSON, M. P. (1994). Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12, 139-153.
    • (1994) Neuron , vol.12 , pp. 139-153
    • Cheng, B.1    Christakos, S.2    Mattson, M.P.3
  • 14
    • 0035116442 scopus 로고    scopus 로고
    • Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy
    • CHRISTIE, R. H., BACSKAI, B. J., ZIPFEL, W. R., WILLIAMS, R. M., KAJDASZ, S. T., WEBB, W. W. & HYMAN, B. T. (2001). Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J. Neurosci. 21, 858-864.
    • (2001) J. Neurosci. , vol.21 , pp. 858-864
    • Christie, R.H.1    Bacskai, B.J.2    Zipfel, W.R.3    Williams, R.M.4    Kajdasz, S.T.5    Webb, W.W.6    Hyman, B.T.7
  • 16
    • 0035473963 scopus 로고    scopus 로고
    • Inherited neurodegenerative diseases: The one-hit model of neurodegeneration
    • CLARKE, G., LUMSDEN, C. J. & MCINNES, R. R. (2001). Inherited neurodegenerative diseases: the one-hit model of neurodegeneration. Hum. Mol. Genet. 10, 1-7.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1-7
    • Clarke, G.1    Lumsden, C.J.2    McInnes, R.R.3
  • 17
    • 0027270578 scopus 로고
    • A kinetic model for amyloid formation in the prion diseases: Importance of seeding
    • COME, J. H., FRASER, P. E. & LANSBURY JR., P. T. (1993). A kinetic model for amyloid formation in the prion Diseases: Importance of seeding, PNAS 90, 5959-5963.
    • (1993) PNAS , vol.90 , pp. 5959-5963
    • Come, J.H.1    Fraser, P.E.2    Lansbury P.T., Jr.3
  • 19
    • 0027099863 scopus 로고
    • The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes
    • DAVIS, J. B., MCMURRAY, H. F. & SCHUBERT, D. (1992). The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. Biochem. Biophys. Res. Commun. 189, 1096-1100.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 1096-1100
    • Davis, J.B.1    McMurray, H.F.2    Schubert, D.3
  • 20
    • 0024565685 scopus 로고
    • Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide
    • DING, A. H., SANCHEZ, E., SRIMAL, S. & NATHAN, C. F. (1989). Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide. J. Biol. Chem. 264, 3924-3929.
    • (1989) J. Biol. Chem. , vol.264 , pp. 3924-3929
    • Ding, A.H.1    Sanchez, E.2    Srimal, S.3    Nathan, C.F.4
  • 22
    • 0025742947 scopus 로고
    • Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction
    • DRIPPS, D. J., BRANDHUBER, B. J., THOMPSON, R. C. & EISENBERG, S. P. (1991). Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J. Biol. Chem. 266, 10331-10336.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10331-10336
    • Dripps, D.J.1    Brandhuber, B.J.2    Thompson, R.C.3    Eisenberg, S.P.4
  • 25
    • 0034728670 scopus 로고    scopus 로고
    • Beta-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
    • EKINCI, F. J., LINSLEY, M.-D. & SHEA, T. B. (2000). Beta-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Mol. Brain Res. 76, 389-395.
    • (2000) Mol. Brain Res. , vol.76 , pp. 389-395
    • Ekinci, F.J.1    Linsley, M.-D.2    Shea, T.B.3
  • 26
  • 27
    • 0034625007 scopus 로고    scopus 로고
    • Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes
    • ENDY, D., YOU, L., YIN, J. & MOLINEUX, I. J. (2000). Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes. Proc. Natl Acad. Sci. U.S.A. 97, 5375-5380.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 5375-5380
    • Endy, D.1    You, L.2    Yin, J.3    Molineux, I.J.4
  • 30
    • 84884676257 scopus 로고    scopus 로고
    • An image-based model of calcium waves in differentiated neuroblastoma cells
    • FINK, C. C., SLEPCHENKO, B., MORARU, I. I., WATRAS, J., SCHAFF, J. & LOEW, L. M. (2000). An image-based model of calcium waves in differentiated neuroblastoma cells. Biophys. J. 79, 163-183.
    • (2000) Biophys. J. , vol.79 , pp. 163-183
    • Fink, C.C.1    Slepchenko, B.2    Moraru, I.I.3    Watras, J.4    Schaff, J.5    Loew, L.M.6
  • 31
    • 0026452028 scopus 로고
    • Expression of amyloid precursor protein mRNAs in endothelial, neuronal, and glial cells: Modulation by interleukin-1
    • FORLONI, G., DEMICHELLI, F., GIORGI, S., BENDOTTI, C. & ANGRETTI, N. (1992). Expression of amyloid precursor protein mRNAs in endothelial, neuronal, and glial cells: modulation by interleukin-1. Brain Res. Mol. Brain. Res. 16, 128-134.
    • (1992) Brain Res. Mol. Brain Res. , vol.16 , pp. 128-134
    • Forloni, G.1    Demichelli, F.2    Giorgi, S.3    Bendotti, C.4    Angretti, N.5
  • 32
    • 0027767445 scopus 로고
    • Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: Implications for AIDS neuropathogenesis
    • GELBARD, H. A., DZENKO, K. A., DILORETO, D., DEL CERRO, C., DEL CERRO, M. & EPSTEIN, L.G. (1993). Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev. Neurosci. 15, 417-422.
    • (1993) Dev. Neurosci. , vol.15 , pp. 417-422
    • Gelbard, H.A.1    Dzenko, K.A.2    DiLoreto, D.3    Del Cerro, C.4    Del Cerro, M.5    Epstein, L.G.6
  • 33
    • 0028105846 scopus 로고
    • Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture
    • GIULIAN, D., LI, J., LEARA, B. & KEENEN, C. (1994). Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture, Neurochem. Int. 25, 227-233.
    • (1994) Neurochem. Int. , vol.25 , pp. 227-233
    • Giulian, D.1    Li, J.2    Leara, B.3    Keenen, C.4
  • 35
    • 0030762758 scopus 로고    scopus 로고
    • Diffusion in axon guidance
    • GOODHILL, G. J. (1997). Diffusion in axon guidance. Eur. J. Neurosc. 9, 1414-1421.
    • (1997) Eur. J. Neurosc. , vol.9 , pp. 1414-1421
    • Goodhill, G.J.1
  • 36
    • 0032695731 scopus 로고    scopus 로고
    • Bacterial targets and antibiotics: Genome-based drug discovery
    • GRAY, C. P. & KECK, W. (1999). Bacterial targets and antibiotics: genome-based drug discovery. Cell. Mol. Life Sci. 56, 779-787.
    • (1999) Cell. Mol. Life Sci. , vol.56 , pp. 779-787
    • Gray, C.P.1    Keck, W.2
  • 39
    • 0029965207 scopus 로고    scopus 로고
    • The interleukin-6 (IL-6) partial antagonist (Q159E,T162P) IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex
    • HAMMACHER, A., SIMPSON, R. J. & NICE, E. C. (1996). The interleukin-6 (IL-6) partial antagonist (Q159E,T162P) IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex. J. Biol. Chem. 271, 5464-5473.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5464-5473
    • Hammacher, A.1    Simpson, R.J.2    Nice, E.C.3
  • 40
    • 0001832544 scopus 로고
    • The diffusion transit times: A simple derivation
    • HARDT, S. L. (1981). The diffusion transit times: a simple derivation. Bull. Math. Biol. 43, 89-99.
    • (1981) Bull. Math. Biol. , vol.43 , pp. 89-99
    • Hardt, S.L.1
  • 41
    • 0023518496 scopus 로고
    • A biochemical and kinetic analysis of the interleukin-1 receptor. Evidence for differences in molecular properties of IL-1 receptors
    • HORUK, R., HUANG, J. J., COVINGTON, M. & NEWTON, R. C. (1987). A biochemical and kinetic analysis of the interleukin-1 receptor. Evidence for differences in molecular properties of IL-1 receptors. J. Biol. Chem. 262, 16275-16278.
    • (1987) J. Biol. Chem. , vol.262 , pp. 16275-16278
    • Horuk, R.1    Huang, J.J.2    Covington, M.3    Newton, R.C.4
  • 42
    • 0033581352 scopus 로고    scopus 로고
    • Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation
    • HU, J. & VAN ELDIK, L. J. (1999). Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation. Brain Res. 842, 46-54.
    • (1999) Brain Res. , vol.842 , pp. 46-54
    • Hu, J.1    Van Eldik, L.J.2
  • 45
    • 0028899724 scopus 로고
    • Quantitative analysis of senile plaques in Alzheimer disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)
    • HYMAN, B. T., WEST, H. L., REBECK, G. W., BULDYREV, S. V., MANTEGNA, R. N., UKLEJA, M., HAVLIN S. & STANLEY, H. E. (1995). Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular Epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). PNAS 92, 3586-3590.
    • (1995) PNAS , vol.92 , pp. 3586-3590
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3    Buldyrev, S.V.4    Mantegna, R.N.5    Ukleja, M.6    Havlin, S.7    Stanley, H.E.8
  • 46
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • ITAGAKI, S., MCGEER, P. L., AKIYAMA, H., ZHU, S. & SELKOE, D. (1989). Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol. 24, 173-182.
    • (1989) J. Neuroimmunol. , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 47
    • 0032077890 scopus 로고    scopus 로고
    • Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
    • JEOHN, G. H., KONG, L. Y., WILSON, B., HUDSON, P. & HONG, J. S. (1998). Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures. J Neuroimmunol. 85, 1-10.
    • (1998) J. Neuroimmunol. , vol.85 , pp. 1-10
    • Jeohn, G.H.1    Kong, L.Y.2    Wilson, B.3    Hudson, P.4    Hong, J.S.5
  • 48
    • 0034663061 scopus 로고    scopus 로고
    • Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
    • KIM, W. G., MOHNEY, R. P., WILSON, B., JEOHN, G. H., LIU, B. & HONG, J. S. (2000). Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 20, 6309-6316.
    • (2000) J. Neurosci. , vol.20 , pp. 6309-6316
    • Kim, W.G.1    Mohney, R.P.2    Wilson, B.3    Jeohn, G.H.4    Liu, B.5    Hong, J.S.6
  • 49
    • 0032971129 scopus 로고    scopus 로고
    • Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by nonsteroidal anti-inflammatory drugs (NSAIDS)
    • KLEGERIS, A., WALKER, D. G. & MCGEER, P. L. (1999). Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by nonsteroidal anti-inflammatory drugs (NSAIDS). Neuropharmacology 38, 1017-1025.
    • (1999) Neuropharmacology , vol.38 , pp. 1017-1025
    • Klegeris, A.1    Walker, D.G.2    McGeer, P.L.3
  • 50
    • 0034663520 scopus 로고    scopus 로고
    • Proliferative and migratory responses of astrocytes to in vitro injury
    • KORNYEI, Z., CZIROK, A., VICSEK, T. & MADARASZ, E. (2000). Proliferative and migratory responses of astrocytes to in vitro injury. J. Neurosci. Res. 61, 421-429.
    • (2000) J. Neurosci. Res. , vol.61 , pp. 421-429
    • Kornyei, Z.1    Czirok, A.2    Vicsek, T.3    Madarasz, E.4
  • 51
    • 0027298505 scopus 로고
    • Cytokine production by human fetal microglia and astrocytes, differential induction by lipopolysaccharide and IL-1-beta
    • LEE, S. C., LIU, W., DICKSON, D. W., BROSNAN, C. F. & BERMAN, J. W. (1993). Cytokine production by human fetal microglia and astrocytes, differential induction by lipopolysaccharide and IL-1-beta. J. Immunol. 150, 2659-2667.
    • (1993) J. Immunol. , vol.150 , pp. 2659-2667
    • Lee, S.C.1    Liu, W.2    Dickson, D.W.3    Brosnan, C.F.4    Berman, J.W.5
  • 52
    • 0033917281 scopus 로고    scopus 로고
    • Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons
    • MA, T. C. & ZHU, X. (2000). Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons. Arzneimittelforschung 50, 512-514.
    • (2000) Arzneimittelforschung , vol.50 , pp. 512-514
    • Ma, T.C.1    Zhu, X.2
  • 53
    • 0032507632 scopus 로고    scopus 로고
    • Diffusion heterogeneity and anisotropy in rat hippocampus
    • MAZEL, T., SIMONOVA, Z. & SYKOVA, E. (1998). Diffusion heterogeneity and anisotropy in rat hippocampus. Neuroreport. 9, 1299-1304.
    • (1998) Neuroreport , vol.9 , pp. 1299-1304
    • Mazel, T.1    Simonova, Z.2    Sykova, E.3
  • 54
    • 0025345605 scopus 로고
    • Induction of tumor necrosis factor-alpha and its receptors during differentiation in myeloid leukemic cells along the monocytic pathway. A possible regulatory mechanism for TNF-alpha production
    • MICHISHITA, M., YOSHIDA, Y., UCHINO, H. & NAGATA, K. (1990). Induction of tumor necrosis factor-alpha and its receptors during differentiation in myeloid leukemic cells along the monocytic pathway. A possible regulatory mechanism for TNF-alpha production. J. Biol. Chem. 265, 8751-8759.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8751-8759
    • Michishita, M.1    Yoshida, Y.2    Uchino, H.3    Nagata, K.4
  • 55
    • 0032731763 scopus 로고    scopus 로고
    • Brain inflammation in Alzheimer disease and the therapeutic implications
    • MCGEER, E. G. & MCGEER, P. L. (1999). Brain inflammation in Alzheimer disease and the therapeutic implications. Curr. Pharmaceut. Des. 5, 821-836.
    • (1999) Curr. Pharmaceut. Des. , vol.5 , pp. 821-836
    • McGeer, E.G.1    McGeer, P.L.2
  • 56
    • 0031593604 scopus 로고    scopus 로고
    • Mechanisms of cell death in Alzheimer disease - Immunopathology
    • MCGEER, P. L. & MCGEER, E. G. (1998a). Mechanisms of cell death in Alzheimer disease - immunopathology. J. Neural Transmission. (Suppl.) 54, 159-166.
    • (1998) J. Neural Transmission. (Suppl.) , vol.54 , pp. 159-166
    • McGeer, P.L.1    McGeer, E.G.2
  • 57
    • 0032146978 scopus 로고    scopus 로고
    • The importance of inflammatory mechanisms in Alzheimer disease
    • MCGEER, E. G. & MCGEER, P. L. (1998b). The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33, 371-378.
    • (1998) Exp. Gerontol. , vol.33 , pp. 371-378
    • McGeer, E.G.1    McGeer, P.L.2
  • 58
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • MCGEER, P. L. & MCGEER, E. G. (1995). The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain. Res. Brain. Res. Rev. 21, 195-218.
    • (1995) Brain Res. Brain Res. Rev. , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 61
    • 0028908051 scopus 로고
    • Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay
    • MOGHE, P. V., NELSON, R. D. & TRANQUILLO, R. T. (1995). Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay. J. Immunol. Methods 180, 193-211.
    • (1995) J. Immunol. Methods , vol.180 , pp. 193-211
    • Moghe, P.V.1    Nelson, R.D.2    Tranquillo, R.T.3
  • 62
    • 0033528666 scopus 로고    scopus 로고
    • Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A using physiological concentrations
    • MOIR, R. D., ATWOOD, C. S., ROMANO, D. M., LAURANS, M. H., HUANG, X., BUSH, A. I., SMITH, J. D. & TANZI, R. E. (1999). Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A using physiological concentrations. Biochemistry 38, 4595-4603.
    • (1999) Biochemistry , vol.38 , pp. 4595-4603
    • Moir, R.D.1    Atwood, C.S.2    Romano, D.M.3    Laurans, M.H.4    Huang, X.5    Bush, A.I.6    Smith, J.D.7    Tanzi, R.E.8
  • 63
    • 0029161781 scopus 로고
    • Glial cytokines in Alzheimer's disease: Review and pathogenic implications
    • MRAK, R. E., SHENG, J. G. & GRIFFIN, W. S. T. (1995). Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum. Pathol. 26, 816-823.
    • (1995) Hum. Pathol. , vol.26 , pp. 816-823
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.T.3
  • 64
    • 0001952025 scopus 로고    scopus 로고
    • Glial cytokines in neurodegenerative conditions
    • (Patterson, P. H., Kordon, C., Christen, Y. eds). Berlin Heidelberg: Springer-Verlag
    • MRAK, R. E., SHENG, J. G. & GRIFFIN, W. S. T. (2000). Glial cytokines in neurodegenerative conditions. In: Neuro-lmmune Interactions in Neurologic and Psychiatric Disorders (Patterson, P. H., Kordon, C., Christen, Y. eds). Berlin Heidelberg: Springer-Verlag.
    • (2000) Neuro-lmmune Interactions in Neurologic and Psychiatric Disorders
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.T.3
  • 65
    • 0032079334 scopus 로고    scopus 로고
    • Extracellular space structure revealed by diffusion analysis
    • Nicholson, C. & Sykova, E. (1998). Extracellular space structure revealed by diffusion analysis. Trends in Neurosciences 21, 207-215.
    • (1998) Trends in Neurosciences , vol.21 , pp. 207-215
    • Nicholson, C.1    Sykova, E.2
  • 66
    • 0342592138 scopus 로고    scopus 로고
    • Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton
    • NOLTE, C., MOELLER, T., WALTER, T. & KETTENMANN, H. (1996). Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton. Neuroscience 73, 1091-1107.
    • (1996) Neuroscience , vol.73 , pp. 1091-1107
    • Nolte, C.1    Moeller, T.2    Walter, T.3    Kettenmann, H.4
  • 67
    • 0030802319 scopus 로고    scopus 로고
    • Epidermal growth factor is a motility factor for microglial cells in vitro: Evidence for EGF receptor expression
    • NOLTE, C., KIRCHHOFF, F. & KETTENMANN, H. (1997). Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression. Eur. J. Neurosc. 9, 1690-1698.
    • (1997) Eur. J. Neurosc. , vol.9 , pp. 1690-1698
    • Nolte, C.1    Kirchhoff, F.2    Kettenmann, H.3
  • 68
    • 0033999569 scopus 로고    scopus 로고
    • Development of predictive pharmacokinetic simulation models for drug discovery
    • NORRIS, D. A., LEESMAN, G. D., SINKO, P. J. & GRASS, G. M. (2000). Development of predictive pharmacokinetic simulation models for drug discovery. J. Control. Release 65, 55-62.
    • (2000) J. Control. Release , vol.65 , pp. 55-62
    • Norris, D.A.1    Leesman, G.D.2    Sinko, P.J.3    Grass, G.M.4
  • 69
    • 0033764285 scopus 로고    scopus 로고
    • The challenges of in silico biology
    • PALSSON, B. (2000). The challenges of in silico biology. Nat. Biotechnol. 18, 1147-1150.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 1147-1150
    • Palsson, B.1
  • 70
    • 0026758256 scopus 로고
    • Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation
    • PENNICA, D., LAM, V. T., MIZE, N. K., WEBER, R. F., LEWIS, M., FENDLY, B. M., LIPARI, M. T. & GOEDDEL, D. V. (1992). Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation. J. Biol. Chem. 267, 21 172-21 178.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21172-21178
    • Pennica, D.1    Lam, V.T.2    Mize, N.K.3    Weber, R.F.4    Lewis, M.5    Fendly, B.M.6    Lipari, M.T.7    Goeddel, D.V.8
  • 72
    • 0024940626 scopus 로고
    • Transport models for chemotactic cell populations based on individual cell behaviour
    • RIVERO, M. A., TRANQUILLO, R. T., BUETTNER, H. M. & LAUFFENBURGER, D. A. (1989). Transport models for chemotactic cell populations based on individual cell behaviour. Chem. Eng. Sci. 44, 2881-2897.
    • (1989) Chem. Eng. Sci. , vol.44 , pp. 2881-2897
    • Rivero, M.A.1    Tranquillo, R.T.2    Buettner, H.M.3    Lauffenburger, D.A.4
  • 73
    • 0030739712 scopus 로고    scopus 로고
    • A general computational framework for modeling cellular structure and function
    • SCHAFF, J., FINK, C., SLEPCHENKO, B., CARSON, J. & LOEW, L. (1997). A general computational framework for modeling cellular structure and function. Biophys. J. 73, 1135-1146.
    • (1997) Biophys. J. , vol.73 , pp. 1135-1146
    • Schaff, J.1    Fink, C.2    Slepchenko, B.3    Carson, J.4    Loew, L.5
  • 74
    • 0025991945 scopus 로고
    • Amyloid protein and Alzheimer's disease
    • SELKOE, D. J. (1991). Amyloid protein and Alzheimer's disease. Sci. Am. 265, 68-78.
    • (1991) Sci. Am. , vol.265 , pp. 68-78
    • Selkoe, D.J.1
  • 76
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and In vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • SHENG, J. G., ITO, K., SKINNER, R. D., MRAK, R. E., ROVNAGHI, C. R., VAN ELDIK, L. J., GRIFFIN, W. S. T. (1996). In vivo and In vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol. Aging 17, 761-766.
    • (1996) Neurobiol. Aging , vol.17 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3    Mrak, R.E.4    Rovnaghi, C.R.5    Van Eldik, L.J.6    Griffin, W.S.T.7
  • 77
    • 0031909973 scopus 로고    scopus 로고
    • Enlarged and phagocytic, but not primed, interleukin-1alpha immunoreactive microglia increase with age in normal human brain
    • SHENG, J. G., MRAK, R. E. & GRIFFIN, W. S. T. (1997). Enlarged and phagocytic, but not primed, inter-leukin-1alpha immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 95, 229-234.
    • (1997) Acta Neuropathol. , vol.95 , pp. 229-234
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.T.3
  • 78
    • 0033624408 scopus 로고    scopus 로고
    • Cytokines in CNS disorders: Neurotoxicity versus neuroprotection
    • STOLL, G., JANDER, S. & SCHROETER, M. (2000). Cytokines in CNS disorders: neurotoxicity versus neuroprotection. J. Neural. Transm. (Suppl) 59, 81-89.
    • (2000) J. Neural Transm. (Suppl.) , vol.59 , pp. 81-89
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 80
    • 0001011354 scopus 로고    scopus 로고
    • The extracellular space in the CNS: Its regulation, volume, and geometry in normal and pathological neuronal function
    • SYKOVA, E. (1997). The extracellular space in the CNS: its regulation, volume, and geometry in normal and pathological neuronal function. Neuroscientist 3, 28-41.
    • (1997) Neuroscientist , vol.3 , pp. 28-41
    • Sykova, E.1
  • 81
    • 0032428945 scopus 로고    scopus 로고
    • Diffusion constraints and neuron-glia interaction during aging
    • SYKOVA, E., MAZEL, T. & SIMONOVA, Z. (1998). Diffusion constraints and neuron-glia interaction during aging. Exp. Gerontol. 33, 837-851.
    • (1998) Exp. Gerontol. , vol.33 , pp. 837-851
    • Sykova, E.1    Mazel, T.2    Simonova, Z.3
  • 83
    • 0032868874 scopus 로고    scopus 로고
    • Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia
    • TARKOWSKI, E., BLENNOW, K., WALLIN, A., TARKOWSKI, A. (1999). Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia. J Clin. Immunol. 19, 223-230.
    • (1999) J. Clin. Immunol. , vol.19 , pp. 223-230
    • Tarkowski, E.1    Blennow, K.2    Wallin, A.3    Tarkowski, A.4
  • 87
    • 0033168292 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) production by astrocytes: Autocrine regulation by IL-6 and the soluble IL-6 receptor
    • VAN WAGONER, N. J., OH, J. W., REPOVIC, P. & BENVENISTE, E. N. (1999). Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J. Neurosci 19, 5236-5244.
    • (1999) J. Neurosci. , vol.19 , pp. 5236-5244
    • Van Wagoner, N.J.1    Oh, J.W.2    Repovic, P.3    Benveniste, E.N.4
  • 88
    • 0031583918 scopus 로고    scopus 로고
    • Microglial phagocytosis is modulated by pro- and anti-inflammatory cytokines
    • VON ZAHN, J., MOELLER, T., KETTENMANN, H. & NOLTE, C. (1997). Microglial phagocytosis is modulated by pro-and anti-inflammatory cytokines. Neuroreport 8, 3851-3856.
    • (1997) Neuroreport , vol.8 , pp. 3851-3856
    • Von Zahn, J.1    Moeller, T.2    Kettenmann, H.3    Nolte, C.4
  • 89
    • 0026564424 scopus 로고
    • Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory factor
    • YAMAGUCHI, M., MICHISHITA, M., HIRAYOSHI, K., YASUKAWA, K., OKUMA, M. & NAGATA, K. (1992) Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory factor. J. Biol. Chem. 267, 22 035-22 042.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22035-22042
    • Yamaguchi, M.1    Michishita, M.2    Hirayoshi, K.3    Yasukawa, K.4    Okuma, M.5    Nagata, K.6


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