The interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex

Journal of Biological Chemistry

Volumn 271, Issue 10, 1996, Pages 5464-5473

  Hammacher, Annet ^a,c   Simpson, Richard J ^a   Nice, Edouard C ^b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 DERIVATIVE; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOSENSOR; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BASE SEQUENCE; CHROMATOGRAPHY, GEL; DNA PRIMERS; HUMANS; INTERLEUKIN-6; KINETICS; MACROMOLECULAR SUBSTANCES; MATHEMATICS; MODELS, THEORETICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; REGRESSION ANALYSIS;

EID: 0029965207     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.10.5464     Document Type: Article

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