Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 1058-1071

  Raney, Anneke K ^a   Johnson, Jennifer L ^a   Palmer, Colin N A ^b   Mclachlan, Alan ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; PEROXISOME PROLIFERATOR; RETINOID X RECEPTOR;

ARTICLE; CONTROLLED STUDY; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA SYNTHESIS; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS NUCLEOCAPSID; VIRUS TRANSCRIPTION;

EID: 0031034798     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.1058-1071.1997     Document Type: Article

References (80)

1. Araki, K., J. Miyazaki, O. Hino, N. Tomita, O. Chisaka, K. Matsubara, and K. Yamamura. 1989. Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Natl. Acad. Sci. USA 86:207-211.
2. Briggs, M. R., J. T. Kadonaga, S. P. Bell, and R. Tjian. 1986. Purification and biochemical characterization of the promoter-specific transcription factor, SP1. Science 234:47-52.
3. Cattaneo, R., H. Will, N. Hernandez, and H. Schaller. 1983. Signals regulating hepatitis B surface antigen transcription. Nature 305:336-338.
4. Cattaneo, R., H. Will, and H. Schaller. 1984. Hepatitis B virus transcription in the infected liver. EMBO J. 3:2191-2196.
5. Chang, H., B. Wang, C. Yuh, C. Wei, and L. Ting. 1989: A liver-Specific nuclear factor interacts with the promoter region of the large surface protein gene of human hepatitis-B virus. Mol. Cell. Biol. 9:5189-5197.
6. Chang, H. K., C. K. Chou, C. Chang, T. S. Su, C. Hu, M. Yoshida, and L. P. Ting. 1987. The enhancer sequence of human hepatitis B virus can enhance the activity of its surface gene promoter. Nucleic Acids Res. 15:2261-2268.
7. Chen, D., G. Lepar, and B. Kemper. 1994. A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J. Biol. Chem. 269: 5420-5427.
8. Chen, I.-H., C.-J. Huang, and L.-P. Ting. 1995. Overlapping initiator and TATA box functions in the basal core promoter of hepatitis B virus. J. Virol. 69:3647-3657.
9. Chen, M., S. Hieng, X. Qian, R. Costa, and J. H. Ou. 1994. Regulation of hepatitis B virus ENI activity by hepatocyte-enriched transcription factor HNF3. Virology 205:127-132
10. De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
11. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
12. Dikstein, R., O. Faktor, and Y. Shaul. 1990. Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer. Mol. Cell. Biol. 10:4427-4430.
13. Dubois, M. F., C. Pourcel, S. Rousset, C. Chany, and P. Tiollais. 1980. Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA. Proc. Natl. Acad. Sci. USA 77:4549-4553.
14. Farza, H., M. Hadchouel, J. Scotto, P. Tiollais, C. Babinet, and C. Pourcel. 1988. Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J. Virol. 62:4144-4152.
15. Galibert, F., E. Mandart, F. Fitoussi, P. Tiollais, and P. Charnay. 1979. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281:646-650.
16. Ganem, D., and H. E. Varmus. 1987. The molecular biology of the hepatitis B viruses. Annu. Rev. Biochem. 56:651-693.
17. Garcia, A. D., P. Ostapchuk, and P. Hearing. 1993. Functional interaction of nuclear factors EF-C, HNF-4, and RXRα with hepatitis B virus enhancer I. J. Virol. 67:3940-3950.
18. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
19. Guidotti, L. G., B. Matzke, H. Schaller, and F. V. Chisari. 1995. High-level hepatitis B virus replication in transgenic mice. J. Virol. 69:6158-6169.
20. Guo, W., M. Chen, T. S. B. Yen, and J.-H. Ou. 1993. Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol. Cell. Biol. 13:443-448.
21. Heyman, R. A., D. J. Mangelsdorf, J. A. Dyck, R. B. Stein, G. Eichele, R. M. Evans, and C. Thaller. 1992. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68:397-406.
22. Honigwachs, J., O. Faktor, R. Dikstein, Y. Shaul, and O. Laub. 1989. Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer. J. Virol. 63:919-924.
23. Hu, K.-Q., and A. Siddiqui. 1991. Regulation of the hepatitis B virus gene expression by the enhancer element I. Virology 181:721-726.
24. Huan, B., M. J. Kosovsky, and A. Siddiqui. 1995. Retinoid X receptor a transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor. J. Virol. 69:547-551.
25. Huan, B., and A. Siddiqui. 1992. Retinoid X receptor RXRα binds to and transactivates the hepatitis B virus enhancer. Proc. Natl. Acad. Sci. USA 89:9059-9063.
26. Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650.
27. Johnson, J. L., A. K. Raney, and A. McLachlan. 1995. Characterization of a functional hepatocyte nuclear factor 3 binding site in the hepatitis B virus nucleocapsid promoter. Virology 208:147-158.
28. Kaneko, S., and R. H. Miller. 1988. X-region-specific transcript in mammalian hepatitis B virus-infected liver. J. Virol. 62:3979-3984.
29. Kliewer, S. A., K. Umesono, R. A. Heyman, D. J. Mangelsdorf, J. A. Dyck, and R. M. Evans. 1996. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc. Natl. Acad. Sci. USA 89:1448-1452.
30. Kliewer, S. A., K. Umesono, D. J. Noonan, R. A. Heyman, and R. M. Evans. 1992. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771-774.
31. Kurosaki, M., N. Enomoto, Y. Asahina, I. Sakuma, T. Ikeda, S. Tozuka, N. Izumi, F. Marumo, and C. Sato. 1996. Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B. J. Med. Virol. 49:115-123.
32. Le, H. B., P. A. Vaisanen, J. L. Johnson, A. K. Raney, and A. McLachlan. 1994. Regulation of transcription from the human muscle phosphofructokinase P2 promoter by the Sp1 transcription factor. DNA Cell Biol. 13:473-485.
33. Levin, A. A., L. J. Sturzenbecker, S. Kazmer, T. Bosakowski, C. Huselton, G. Allenby, J. Speck, C. Kratzeisen, M. Rosenberger, A. Lovey, and J. F. Grippo. 1992. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature 355:359-361.
34. Li, M., Y. H. Xie, X. Wu, Y. Y. Kong, and Y. Wang. 1995. HNF3 binds and activates the second enhancer, ENII, of hepatitis B virus. Virology 214:371-378.
35. López-Cabrera, M., J. Letovsky, K.-Q. Hu, and A. Siddiqui. 1990. Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: transactivation and repression by CCAAT/enhancer binding protein. Proc. Natl. Acad. Sci. USA 87:5069-5073.
36. López-Cabrera, M., J. Letovsky, K.-Q. Hu, and A. Siddiqui. 1991. Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus. Virology 183:825-829.
37. Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850.
38. Mangelsdorf, D. J., E. S. Ong, J. A. Dyck, and R. M. Evans. 1990. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345: 224-229.
39. Muerhoff, A. S., K. J. Griffin, and E. F. Johnson. 1992. The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid. J. Biol. Chem. 267:19051-19053.
40. Nakabayashi, H., K. Taketa, K. Miyano, T. Yamane, and J. Sato. 1982. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium. Cancer Res. 42:3858-3863.
41. Nakshatri, H., and P. Chambon. 1994. The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. J. Biol. Chem. 269:890-902.
42. Nishizono, A., M. Hiraga, K. Kohno, Y. T. Sonoda, H. Terao, T. Fujioka, M. Nasu, and K. Mifune. 1995. Mutations in the core promoter enhancer II regions of naturally occurring hepatitis B virus variants and analysis of the effects on transcription activities. Intervirology 38:290-294.
43. Okamoto, H., F. Tsuda, Y. Akahane, Y. Sugai, M. Yoshiba, K. Moriyama, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1994. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J. Virol. 68:8102-8110.
44. Ori, A., and Y. Shaul. 1995. Hepatitis B virus enhancer binds and is activated by the hepatocyte nuclear factor 3. Virology 207:98-106.
45. Palmer, C. N. A., M.-H. Hsu, K. J. Griffin, and E. F. Johnson. 1995. Novel sequence determinants in peroxisome proliferator signaling. J. Biol. Chem. 270:16114-16121.
46. Palmer, C. N. A., M.-H. Hsu, A. S. Muerhoff, K. J. Griffin, and E. F. Johnson. 1994. Interaction of the peroxisome proliferator-activated receptor α with the retinoid X receptor a unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1 binding site in the CYP4A6 promoter. J. Biol. Chem. 269:18083-18089.
47. Pei, D., and C. Shih. 1990. Transcriptional activation and repression by cellular DNA-binding protein C/EBP. J. Virol. 1517:1522.
48. Puck, T. T., P. I. Marcus, and S. J. Cieciura. 1956. Clonal growth of mammalian cells in vitro: growth characteristics of colonies from single HeLa cells with and without a "feeder" layer. J. Exp. Med. 103:273-284.
49. Raney, A. K., A. J. Easton, and A. McLachlan. 1994. Characterization of the minimal elements of the hepatitis B virus large surface antigen promoter. J. Gen. Virol. 75:2671-2679.
50. Raney, A. K., A. J. Easton, D. R. Milich, and A. McLachlan. 1991. Promoter-specific transactivation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1. J. Virol. 65:5774-5781.
51. Raney, A. K., H. B. Le, and A. McLachlan. 1992. Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor. J. Virol. 66:6912-6921.
52. Raney, A. K., and A. McLachlan. 1991. The biology of hepatitis B virus, p. 1-37. In A. McLachlan (ed.), Molecular biology of the hepatitis B virus. CRC Press, Inc., Boca Raton, Fla.
53. Raney, A. K., and A. McLachlan. Unpublished data.
54. Raney, A. K., D. R. Milich, A. J. Easton, and A. McLachlan. 1990. Differentiation specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines. J. Virol. 64:2360-2368.
55. Raney, A. K., D. R. Milich, and A. McLachlan. 1989. Characterization of hepatitis B virus major surface antigen gene transcriptional regulatory elements in differentiated hepatoma cell lines. J. Virol. 63:3919-3925.
56. Raney, A. K., D. R. Milich, and A. McLachlan. 1991. Complex regulation of transcription from the hepatitis B virus major surface antigen promoter in human hepatoma cell lines. J. Virol. 65:4805-4811.
57. Raney, A. K., P. Zhang, and A. McLachlan. 1995. Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3. J. Virol. 69:3265-3272.
58. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
59. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
60. Sells, M. A., A. Z. Zelent, M. Shvartsman, and G. Acs. 1988. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J. Virol. 62:2836-2844.
61. Shaul, Y., R. Ben Levy, and T. De Medina. 1986. High affinity binding site for nuclear factor I next to the hepatitis B virus S gene promoter. EMBO J. 5:1967-1971.
62. Sladek, F. M., W. Zhong, E. Lai, and J. E. Darnell, Jr. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353-2365.
63. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Eschericthia coli as fusions with glutathione S-transferase. Gene 67:31-40.
64. Sorge, J., D. Wright, V. D. Erdman, and A. E. Cutting. 1984. Amphotropic retrovirus vector system for human cell gene transfer. Mol. Cell. Biol. 4:1730-1737.
65. Su, H., and J.-K. Yee. 1992. Regulation of hepatitis B virus gene expression by its two enhancers. Proc. Natl. Acad. Sci. USA 89:2708-2712.
66. Su, T., W. Lui, L. Lin, S. Han, and F. P'eng. 1989. Analysis of hepatitis B virus transcripts in infected human livers. Hepatology 9:180-185.
67. 1764) of hepatitis B virus: clinical significance and an easy method for detection. J. Gen. Virol. 76:3159-3164.
68. Thompson, C. M., A. J. Koleske, D. M. Chao, and R. A. Young. 1993. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73:1361-1375.
69. Waisman, A., Y. Aloni, and O. Laub. 1990. In vitro regulation of human hepatitis B virus core gene transcription. Virology 177:737-744.
70. Wang, L.-H., S. Y. Tsai, R. G. Cook, W. G. Beattie, M.-J. Tsai, and B. W. O'Malley. 1989. COUP transcription factor is a member of the steroid receptor superfamily. Nature 340:163-166.
71. Yaginuma, K., Y. Shirakata, M. Kobayashi, and K. Koike. 1987. Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc. Natl. Acad. Sci. USA 84:2678-2682.
72. Yen, T. S. B. 1993. Regulation of hepatitis B virus gene expression. Semin. Virol. 4:33-42.
73. Yokosuka, O., M. Omata, F. Imazeki, Y. Ito, and K. Okuda. 1986. Hepatitis B virus RNA transcripts and DNA in chronic liver disease. N. Engl. J. Med. 315:1187-1192.
74. Yuh, C.-H., and L.-P. Ting. 1990. The genome of hepatitis B virus contains a second enhancer: Cooperation of two elements within this enhancer is required for its function. J. Virol. 64:4281-4287.
75. Yuh, C.-H., and L.-P. Ting. 1991. C/EBP-like proteins binding to the functional box-α and box-β of the second enhancer of hepatitis B virus. Mol. Cell. Biol. 11:5044-5052.
76. Zhang, P., and A. McLachlan. 1994. Differentiation-specific transcriptional regulation of the hepatitis B virus nucleocapsid gene in human hepatoma cell lines. Virology 202:430-440.
77. Zhang, P., A. K. Raney, and A. McLachlan. 1992. Characterization of the hepatitis B virus X- and nucleocapsid gene transcriptional regulatory elements. Virology 191:31-41.
78. Zhang, P., A. K. Raney, and A. McLachlan. 1993. Characterization of functional Sp1 transcription factor binding sites in the hepatitis B virus nucleo-capsid promoter. J. Virol. 67:1472-1481.
79. Zhou, D.-X., and T. S. B. Yen. 1990. Differential regulation of the hepatitis B virus surface gene promoters by a second viral enhancer. J. Biol. Chem. 265:20731-20734.
80. Zhou, D.-X., and T. S. B. Yen. 1991. The ubiquitous transcription factor Oct-1 and the liver-specific factor HNF-1 are both required to activate transcription of a hepatitis B virus promoter. Mol. Cell. Biol. 11:1353-1359.