Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 9366-9374

  Yu, Xianming ^a   Mertz, Janet E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR; RETINOID X RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHICKEN; GENE REPLICATION; GENETIC TRANSCRIPTION; GENOME; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; OPEN READING FRAME; PEROXISOME; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030862340     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.9366-9374.1997     Document Type: Article

References (58)

1. Beasley, R. P. 1988. Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer. 61:1942-1956.
2. Brun, R. P., P. Tontonoz, B. M. Forman, R. Ellis, J. Chen, R. M. Evans, and B. M. Spiegelman. 1996. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 10:974-984.
3. Buckwold, V. E., Z. Xu, M. Chen, T. S. B. Yen, and J.-H. Ou. 1996. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J. Virol. 70:5845-5851.
4. Butz, K., and F. Hoppe-Seyler. 1993. Transcriptional control of human papillomavirus (HPV) oncogene expression: composition of the HPV type 18 upstream regulatory region. J. Virol. 67:6476-6486.
5. Carter, M. E., T. Gulick, B. D. Raisher, T. Caira, J. A. A. Ladias, D. D. Moore, and D. P. Kelly. 1993. Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. J. Biol. Chem. 268:13805-13810.
6. Castelein, H., T. Gulick, P. E. Declercq, G. P. Mannaerts, D. D. Moore and M. I. Baes. 1994. The peroxisome proliferator activated receptor regulates malic enzyme gene expression. J. Biol. Chem. 269:26754-26758.
7. Chang, C., and J. Kokontis. 1988. Identification of a new member of the steroid receptor super-family by cloning and sequence analysis. Biochem. Biophys. Res. Commun. 155:971-977.
8. Chomczynski, P. 1994. Current protocols in molecular biology, p. 4.2.4.-4.2.8. John Wiley & Sons, Inc, New York, N.Y.
9. Cooney, A. J., S. Y. Tsai, B. W. O'Malley, and M.-J. Tsai. 1992. Chicken ovalbumin upstream promoter transcription factor (COUP TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol. Cell. Biol. 12:4153-4163.
10. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
11. Farza, H., M. Hadchouel, J. Scotto, P. Tiollais, C. Babinet, and C. Pourcel. 1988. Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J. Virol. 62:4144-4152.
12. 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812.
13. Galson, D. L., T. Tsuchiya, D. S. Tendler, L. E. Huang, Y. Ren, T. Ogura, and H. F. Bunn. 1995. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol. Cell. Biol. 15:2135-2144.
14. Ganem, D. 1996. Hepadnaviridae and their replication, p. 2703-2739. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
15. Ganem, D., and H. E. Varmus. 1987. The molecular biology of the hepatitis B viruses. Annu. Rev. Biochem. 56:651-693.
16. Garcia, A. D., P. Ostapchuk, and P. Hearing. 1993. Functional interaction of nuclear factors EF-C, HNF-4, and RXRα with hepatitis B virus enhancer I. J. Virol. 67:3940-3950.
17. Guidotti, L. G., B. Matzke, C. Pasquinelli, J. M. Shoenberger, C. E. Rogler, and F. V. Chisari. 1996. The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice. J. Virol. 70:7056-7061.
18. Guo, W., M. Chen, T. S. B. Yen, and J.-H. Ou. 1993. Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol. Cell. Biol. 13:443-448.
19. Hall, R. K., F. M. Sladek, and D. K. Granner. 1995. The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Proc. Natl. Acad. Sci. USA 92:412-416.
20. 2 in human urine. J. Biol. Chem. 263:16619-16625.
21. Huan, B., and A. Siddiqui. 1992. Retinoid X receptor RXRα binds to and trans-activates the hepatitis B virus enhancer. Proc. Natl. Acad. Sci. USA 89:9059-9063.
22. Huan, B., M. J. Kosovsky, and A. Siddiqui. 1995. Retinoid X receptor α transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor J. Virol. 69:547-551.
23. Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650.
24. Johnston, S. D., X. Liu, F. Zuo, T. L. Eisenbraun, S. R. Wiley, R. J. Kraus, and J. E. Mertz. 1997. Estrogen-related receptor α1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol. Endocrinol. 11:342-352.
25. Kimura, A., A. Nishiyori, T. Murakami, T. Tsukamoto, S. Hata, T. Osumi, R. Okamura, M. Mori, and M. Takiguchi. 1993. Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses transcription from the promoter of the gene for ornithine transcarbamylase in a manner antagonistic to hepatocyte nuclear factor-4 (HNF-4). J. Biol. Chem. 268:11125-11133.
26. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819.
27. Ladias, J. A. A., M. Hadzopoulou-Cladaras, D. Kardassis, P. Cardot, J. Cheng, V. Zannis, and C. Cladaras. 1992. Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2 and EAR-3. J. Biol. Chem. 267:15849-15860.
28. Lamberts, C., M. Nassal, I. Velhagen, H. Zentgraf, and C. H. Schroder. 1993. Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis. J. Virol. 67:3756-3762.
29. Lazar, M. A. 1993. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocrine Rev. 14:184-193.
30. Lee, H.-J., and C. Chang. 1995. Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter. J. Biol. Chem. 270:5434-5440.
31. Leid, M., P. Kastner, R. Lyons, H. Nakshatri, M. Saunders, T. Zacharewski, J.-Y. Chen, A. Staub, J.-M. Garnier, S. Mader, and P. Chambon. 1992. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68: 377-395.
32. Leng, X., A. J. Cooney, S. Y. Tsai, and M.-J. Tsai. 1996. Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression. Mol. Cell. Biol. 16:2332-2340.
33. Mangelsdorf, D. J., E. S. Ong, J. A. Dyck, and R. M. Evans. 1990. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345: 224-229.
34. Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850.
35. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835-839.
36. Okamoto, H., F. Tsuda, Y. Akahane, Y. Sugai, M. Yoshiba, K. Moriyama, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1994. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J. Virol. 68:8102-8110.
37. Qiu, Y. H., S. Y. Tsai, and M.-J. Tsai. 1994. COUP-TF: an orphan member of the steroid/thyroid hormone receptor superfamily. Trends Endocrinol. Metab. 5:234-239.
38. Raisher, B. D., T. Gulick, Z. Zhang, A. W. Strauss, D. D. Moore, and D. P. Kelly. 1992. Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J. Biol. Chem. 267:20264-20269.
39. Raney, A. K., D. R. Milich, A. J. Easton, and A. McLachlan. 1990. Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines. J. Virol. 64:2360-2368.
40. Raney, A. K., J. L. Johnson, C. N. A. Palmer, and A. McLachlan. 1997. Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter. J. Virol. 71:1058-1071.
41. Runkel, L., M. Fischer, and H. Schaller. 1993. Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function. Virology 197:529-536.
42. Sato, S., K. Suzuki, Y. Akahane, K. Akamatsu, K. Akiyama, K. Yunomura, F. Tsuda, T. Tanaka, H. Okamoto, Y. Miyakawa, and M. Mayumi. 1995. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann. Intern. Med. 122:241-248.
43. Schleiss, M. R., C. R. Degnin, and A. P. Geballe. 1991. Translational control of human cytomegalovirus gp48 expression. J. Virol. 65:6782-6789.
44. Sells, M. A., A. Z. Zelent, M. Shvartsman, and G. Acs. 1988. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J. Virol. 62:2836-2844.
45. Sladek, F. M., W. Zhong, E. Lai, and J. E. Darnell, Jr. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353-2365.
46. Tong, M., M. Thursby, J. Lin, J. Weissman, and C. McPeak. 1981. Studies on the maternal-infant transmission of the hepatitis B virus and HBV infection within families. Prog. Med. Virol. 27:137-147.
47. Tontonoz P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234.
48. Tsai, M.-J., and B. W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63: 451-486.
49. Tsai, S. Y., and M.-J. Tsai. 1997. Chicken ovalbumin upstream promoter transcription factors (COUP-TFs): coming of age. Endocrine Rev 18:229-240.
50. Tur-Kaspa, R., R. D. Burk, Y. Shaul, and D. A. Shafritz. 1986. Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc. Natl. Acad. Sci. USA 83:1627-1631.
51. Tur-Kaspa, R., Y. Shaul, D. D. Moore, R. D. Burk, S. Okret, L. Poellinger, and D. A. Shafritz. 1988. The glucocorticoid receptor recognizes a specific nucleotide sequence in hepatitis B virus DNA causing increased activity of the HBV enhancer. Virology 167:630-633.
52. Wiley, S. R., R. J. Kraus, and J. E. Mertz. 1992. Functional binding of the "TATA" box binding component of transcription factor TFIID to the -30 region of TATA-less promoters. Proc. Natl. Acad. Sci. USA 89:5814-5818.
53. Wiley, S. R., R. J. Kraus, F. Zuo, E. E. Murray, K. Loritz, and J. E. Mertz. 1993. SV40 early-to-late switch involves titration of cellular transcriptional repressors. Genes Dev. 7:2206-2219.
54. Willy, P. J., K. Umesono, E. S. Ong, R. M. Evans, R. A. Heyman, and D. J. Mangelsdorf. 1995. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9:1033-1045.
55. Yu, X., and J. E. Mertz. 1996. Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated. J. Virol. 70:8719-8726.
56. Yu, X., and J. E. Mertz. Unpublished data.
57. Zuo, F., and J. E. Mertz. 1995. Simian virus 40 late gene expression is regulated by members of the steroid/thyroid hormone receptor superfamily. Proc. Natl. Acad. Sci. USA 92:8586-8590.
58. Zuo, F., R. J. Kraus, T. Gulick, D. D. Moore, and J. E. Mertz. 1997. Direct modulation of simian virus 40 late gene expression by thyroid hormone and its receptor. J. Virol. 71:427-436.