Prediction of distant metastases after curative surgery for rectal cancer

Journal of Surgical Research

Volumn 103, Issue 1, 2002, Pages 68-78

  Günther, Klaus ^a   Dworak, Otto ^a   Remke, Stefan ^a   Pflüger, Rafael ^a   Merkel, Susanne ^a   Hohenberger, Werner ^a   Reymond, Marc A ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Adjuvant therapy; CD15s; CD44v6; CEA; DCC; E cadherin; EGF R; Extramural venous invasion; Grading; Immunohistochemistry; Lymphatic invasion; Metastases; Multivariate analysis; NM23; P53; PAI 1; Prognosis; Rectal cancer; Tumor marker

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD15 ANTIGEN; CD44V ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; PARAFFIN; PROTEIN; PROTEIN DCC; PROTEIN NM23; PROTEIN P53; PROTEIN PAI 1; TUMOR MARKER; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; AGE; AGED; ANALYTIC METHOD; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENDER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIVARIATE ANALYSIS; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECTUM CARCINOMA; STAINING; STATISTICAL MODEL; TIME; VASCULAR TUMOR;

EID: 0036354852     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2001.6312     Document Type: Article

References (93)

1. Influence of surgery on metachronous distant metastases and survival in rectal cancer
2. Survival of colorectal cancer patients in Europe during the period 1978-1989
3. NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer
4. Lessons from hereditary colorectal cancer
5. A genetic model for colorectal tumorigenesis
6. The deleted in colon cancer (DCC) gene is consistently expressed in colorectal cancers and metastases
7. Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis
8. The DCC protein and prognosis in colorectal cancer
9. Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma
10. CD44V6 expression in human colorectal carcinoma
11. No evidence for cancer-related CD44 splice variants in primary and metastatic colorectal cancer
12. Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer
13. Positive relationship between expression of CD44 and hepatic metastases in colorectal cancer
14. The positive relationship between the expression of CD44 variant 6 and prognosis in colorectal cancer
15. Decreased expression of CD44 splicing variants in advanced colorectal carcinomas
16. CD44 splice variants as prognostic markers in colorectal cancer
17. Expression of CD44, ICAM-1 and N-CAM in colorectal cancer. Correlation with the tumor stage and the phenotypical characteristics of tumor-infiltrating lymphocytes
18. Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients
19. Soluble CD44 variant 6 as a prognostic indicator in patients with colorectal cancer
20. Clinical significance of combined immunohistochemical detection of CD44v and sialyl LeX expression for colorectal cancer patients undergoing curative resection
21. Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis
22. Ectopic expression of carbohydrate antigens that determine the metastatic potential of human colorectal carcinoma
23. Involvement of carbohydrate antigen sialyl Lewis(x) in colorectal cancer metastasis
24. Prognostic significance of circulating antibodies against carcinoembryonic antigen (anti-CEA) in patients with colon cancer
25. Immunohistochemical localization of carcinoembryonic antigen as a predictor of lymph node status in submucosa-invasive colorectal carcinoma
26. Preoperative carcinoembryonic antigen level as an independent prognostic factor in colorectal cancer: Taiwan experience
27. The prognostic value of CEA, beta HCG, AFP, CA125, CA19-9 and C-erb B-2, beta HCG immunohistochemistry in advanced colorectal cancer
28. Immunohistochemical analysis of E-cadherin expression in human colorectal tumours
29. E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study
30. Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome
31. Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling
32. Prognostic significance of E-cadherin expression in human colorectal cancer tissue
33. Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer
34. Cadherin-catenin expression in primary colorectal cancer: A survival analysis
35. Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients
36. Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer
37. Heat shock protein 72 on tumor cells: A recognition structure for natural killer cells
38. Heat shock protein 72/73 in relation to cytoplasmic p53 expression and prognosis in colorectal adenocarcinomas
39. Expression of epidermal growth factor receptor messenger RNA in human colorectal carcinomas assessed by non-radioactive in-situ hybridization
40. Association of epidermal growth factor-related peptides and type I receptor tyrosine kinase receptors with prognosis of human colorectal carcinomas
41. Immunohistochemical study on the expression of epidermal growth factor receptor (EGFR) in human colorectal carcinomas
42. Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns
43. Determination of proliferative activity in colorectal carcinoma using monoclonal antibody Ki67
44. Determination of proliferative activity using Ki67 and expression of p53 in colorectal cancer
45. Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 as a prognostic factor in human colorectal carcinomas
46. Association of immunohistochemical detection of urokinase-type plasminogen activator with metastasis and prognosis in colorectal cancer
47. Prognostic value of plasminogen activators and their inhibitors in colorectal cancer
48. Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: Independent prognostic role of p53 and bcl-2
49. Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis
50. Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma
51. p53 and Bcl-2 as significant predictors of recurrence and survival in rectal cancer
52. p53 alterations are associated with improved prognosis in distal colonic carcinomas
53. The prognostic significance of p53 expression for survival and local control in rectal carcinoma treated with surgery and postoperative radiotherapy
54. Immunohistochemical detection of p53 in colorectal cancer and its relationship to prognosis
55. Evaluation of four antibodies in detecting p53 protein for predicting clinicopathological and prognostic significance in colorectal adenocarcinoma
56. Mutation in the nm23 gene is associated with metastasis in colorectal cancer
57. High level of Nm23-H1 gene expression is associated with local colorectal cancer progression not with metastases
58. Reduced expression of nm23 protein is associated with advanced tumor stage and distant metastases in human colorectal carcinomas
59. Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma
60. Recurrence and survival after total mesorectal excision for rectal cancer
61. The World Health Organization's histologic classification of gastrointestinal tumors. A commentary on the second edition
62. Prognostic factors of rectum carcinoma - Experience of the German Multicentre Study SGCRC
63. Neoadjuvant and adjuvant radio- and radio-chemotherapy of rectal carcinomas
64. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999
65. American Joint Committee on Cancer Prognostic Factors Consensus Conference: Colorectal Working Group
66. The effect of specialization or organization of rectal cancer surgery
67. The effect of specialization or organization of rectal cancer surgery
68. Prognostic factors research. Aims, definition, preconditions
69. Variability in achieving reproducible results in diagnostic immunohistochemistry laboratories
70. Inter-observer variation of p53 immunohistochemistry - An assessment of a practical problem and comparison with other studies
71. Sensitivity of HER-2/neu antibodies in archival tissue samples: Potential source of error in immunohistochemical studies of oncogene expression
72. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer
73. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
74. Factors affecting survival after excision of the rectum for cancer: A multivariate analysis
75. New grade-related prognostic variable for rectal cancer
76. Relevance of histopathologic grading in colonic cancer
77. Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
78. Prognostic factors for patients with colon or rectal carcinoma treated with resection only. Five-year follow-up report
79. Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers
80. Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation
81. DCC protein as a predictor of distant metastases after curative surgery for rectal cancer
82. p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases
83. Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: No evidence for prognostic significance
84. Expression of variant CD44 in colorectal cancer and its relationship to liver metastasis
85. Tumour recurrence is associated with Jass grouping but not with differences in E-cadherin expression in moderately differentiated Dukes' B colorectal cancers
86. Gene expression informatics - It's all in your mine
87. Modelling in surgical oncology - Part III: Massive data sets and complex systems